ES8604167A1 - Un procedimiento para la preparacion de un derivado de acido 2-anilino-1, 6-dihidro-6-oxo-5-pirimidincarboxilico - Google Patents

Un procedimiento para la preparacion de un derivado de acido 2-anilino-1, 6-dihidro-6-oxo-5-pirimidincarboxilico

Info

Publication number
ES8604167A1
ES8604167A1 ES537389A ES537389A ES8604167A1 ES 8604167 A1 ES8604167 A1 ES 8604167A1 ES 537389 A ES537389 A ES 537389A ES 537389 A ES537389 A ES 537389A ES 8604167 A1 ES8604167 A1 ES 8604167A1
Authority
ES
Spain
Prior art keywords
anilino
dihydro
oxo
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537389A
Other languages
English (en)
Other versions
ES537389A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morishita Pharmaceuticals Co Ltd
Original Assignee
Morishita Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morishita Pharmaceuticals Co Ltd filed Critical Morishita Pharmaceuticals Co Ltd
Publication of ES8604167A1 publication Critical patent/ES8604167A1/es
Publication of ES537389A0 publication Critical patent/ES537389A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO 2-ANILINO-1,6-DIHIDRO-6-OXO-5-PIRIMIDINCARBOXILICO, DE FORMULA (I), EN LA QUE R3 REPRESENTA HIDROGENO O ALQUILO; Y R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE 1,6-DIHIDRO-2-METILTIO-6-OXO-6-PIRIMIDIN-CARBOXILATO DE ALQUILO CON UN COMPUESTO DE FORMULA (II), EN LA QUE R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); SEGUIDA DE LA HIDROLISIS OPCIONAL DEL COMPUESTO FORMADO. LA REACCION SE LLEVA A CABO EN AUSENCIA DE DISOLVENTE O EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 50JC Y 200JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA LA PROFILAXIS Y EL TRATAMIENTO DEL ASMA ALERGICO.
ES537389A 1983-11-05 1984-11-05 Un procedimiento para la preparacion de un derivado de acido 2-anilino-1, 6-dihidro-6-oxo-5-pirimidincarboxilico Expired ES8604167A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58207670A JPS60100559A (ja) 1983-11-05 1983-11-05 ２−アニリノ−１，６−ジヒドロ−６−オキソ−５−ピリミジンカルボン酸誘導体，その製法及び該化合物を含有する抗アレルギ−剤

Publications (2)

Publication Number Publication Date
ES8604167A1 true ES8604167A1 (es) 1986-01-16
ES537389A0 ES537389A0 (es) 1986-01-16

Family

ID=16543613

Family Applications (2)

Application Number Title Priority Date Filing Date
ES537389A Expired ES8604167A1 (es) 1983-11-05 1984-11-05 Un procedimiento para la preparacion de un derivado de acido 2-anilino-1, 6-dihidro-6-oxo-5-pirimidincarboxilico
ES546896A Expired ES8605493A1 (es) 1983-11-05 1985-09-11 Un procedimiento para la preparacion de un derivado de acido 2-anilino, 6,1-dihidro-6-oxo-5-pirimidincarboxilico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES546896A Expired ES8605493A1 (es) 1983-11-05 1985-09-11 Un procedimiento para la preparacion de un derivado de acido 2-anilino, 6,1-dihidro-6-oxo-5-pirimidincarboxilico.

Country Status (7)

Country Link
US (1) US4666915A (es)
EP (1) EP0144730B1 (es)
JP (1) JPS60100559A (es)
AT (1) ATE28193T1 (es)
CA (1) CA1218368A (es)
DE (1) DE3464603D1 (es)
ES (2) ES8604167A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
EP0393723B1 (en) * 1989-04-21 1997-07-16 Asahi Kogaku Kogyo Kabushiki Kaisha A functional paper and its use as a deodorant, filtering medium or adsorbent
JP3465393B2 (ja) * 1995-01-06 2003-11-10 トヨタ自動車株式会社 内燃機関用蒸発燃料処理装置
ATE365158T1 (de) * 1999-04-28 2007-07-15 Inst Med Molecular Design Inc Pyrimidincarbonsäurederivate
US7008470B2 (en) 2000-12-25 2006-03-07 Aisan Kogyo Kabushiki Kaisha Canister
MXPA05005547A (es) * 2002-11-28 2005-07-26 Schering Ag Pirimidinas inhibidoras de chk, pdk y akt, su produccion y uso como agentes farmaceuticos.
CA2607934C (en) * 2005-05-06 2013-10-01 E. I. Du Pont De Nemours And Company Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids
JP4918259B2 (ja) * 2006-01-06 2012-04-18 株式会社キャタラー 低分子有機ガス吸収材及びこれを用いた燃料蒸気処理装置
WO2013163159A2 (en) * 2012-04-24 2013-10-31 Board Of Trustees Of Northern Illinois University Design and synthesis of novel inhibitors of isoprenoid biosynthesis
US10155766B2 (en) 2016-06-14 2018-12-18 Board Of Trustees Of Northern Illinois University Pyrazolopyrimidine antibacterial agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB859716A (en) * 1957-07-12 1961-01-25 Cilag Chemie New pyrimidines and their salts and a process for their production
CH376115A (de) * 1957-12-06 1964-03-31 Ciba Geigy Verfahren zur Herstellung neuer substituierter Pyrimidine
DE1670536B2 (de) * 1966-11-09 1975-05-28 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Neue 2-Anilino-5-acylamino-pyrimidlne
US3883653A (en) * 1972-10-24 1975-05-13 Pfizer Method of preventing asthmatic symptoms
US3968213A (en) * 1972-10-24 1976-07-06 Pfizer Inc. Method of preventing asthmatic symptoms
US3917835A (en) * 1972-10-24 1975-11-04 Pfizer A method of preventing asthmatic symptoms
US3957784A (en) * 1972-10-24 1976-05-18 Pfizer Inc. Bis(4-[4'-hydroxy-5'-carboxy-2'-pyrimidinyl]phenoxy)alkanes
US4031093A (en) * 1975-09-09 1977-06-21 Bristol-Myers Company 1,6-Dihydro-6-oxo-2-(ortho-substituted phenyl)pyrimidine-5-carboxylic acid derivatives
DE2735919A1 (de) * 1977-08-10 1979-02-22 Boehringer Sohn Ingelheim Neue 2-pyridyl- und 2-pyrimidylaminobenzoesaeuren

Also Published As

Publication number Publication date
ES8605493A1 (es) 1986-03-16
EP0144730A1 (en) 1985-06-19
JPS60100559A (ja) 1985-06-04
ATE28193T1 (de) 1987-07-15
JPH0336835B2 (es) 1991-06-03
EP0144730B1 (en) 1987-07-08
DE3464603D1 (en) 1987-08-13
ES537389A0 (es) 1986-01-16
ES546896A0 (es) 1986-03-16
CA1218368A (en) 1987-02-24
US4666915A (en) 1987-05-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401