NO941977L - Indolderivater, fremgangsmåte for fremstilling av disse, og medisinsk anvendelse derav - Google Patents
Indolderivater, fremgangsmåte for fremstilling av disse, og medisinsk anvendelse deravInfo
- Publication number
- NO941977L NO941977L NO941977A NO941977A NO941977L NO 941977 L NO941977 L NO 941977L NO 941977 A NO941977 A NO 941977A NO 941977 A NO941977 A NO 941977A NO 941977 L NO941977 L NO 941977L
- Authority
- NO
- Norway
- Prior art keywords
- agent
- processes
- preparation
- medical use
- indole derivatives
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 210000004958 brain cell Anatomy 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000003401 opiate antagonist Substances 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Ny forbindelse som er en 6- opioidantagonist med høy selektivitet og aktivitet, som utviser immunundertrykkende virkning, antiallergisk virk- ning, antiinflammatorisk virkning og hjernecellebeskyttende virkning, er beskrevet. Forbindelsen ifølge forelig- gende oppfinnelse er et indolderivat representert ved formel (I): og farmasøytisk akseptable syreaddi- sjonssalter derav. Foreliggende oppfin- nelse tilveiebringer også et immun-r undertrykkende middel, antiallergimid- del, antiinflammatorisk middel og hjernecellebeskyttende middel, omfat- tende derivatet eller saltet som en effektiv bestanddel.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25984192 | 1992-09-29 | ||
PCT/JP1993/001388 WO1994007896A1 (en) | 1992-09-29 | 1993-09-29 | Indole derivative, process for producing the same, and medicinal use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
NO941977D0 NO941977D0 (no) | 1994-05-27 |
NO941977L true NO941977L (no) | 1994-07-29 |
Family
ID=17339733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO941977A NO941977L (no) | 1992-09-29 | 1994-05-27 | Indolderivater, fremgangsmåte for fremstilling av disse, og medisinsk anvendelse derav |
Country Status (14)
Country | Link |
---|---|
US (2) | US6087369A (no) |
EP (1) | EP0614898B1 (no) |
JP (1) | JP3605825B2 (no) |
KR (1) | KR100301093B1 (no) |
CN (1) | CN1043766C (no) |
AT (1) | ATE239732T1 (no) |
AU (1) | AU672033B2 (no) |
CA (1) | CA2124455C (no) |
DE (1) | DE69332945T2 (no) |
ES (1) | ES2199220T3 (no) |
FI (1) | FI942499A (no) |
NO (1) | NO941977L (no) |
TW (1) | TW271440B (no) |
WO (1) | WO1994007896A1 (no) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2124455C (en) * | 1992-09-29 | 2004-09-14 | Hiroshi Nagase | Indole derivatives, process for producing the same and medicinal uses of the same |
US5464841A (en) * | 1993-11-08 | 1995-11-07 | Univ Minnesota | Use of delta opioid receptor antagonists to treat immunoregulatory disorders |
SE9401728D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds II |
SE9401727D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds I |
US5578725A (en) * | 1995-01-30 | 1996-11-26 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
JP3123080B2 (ja) * | 1995-09-26 | 2001-01-09 | 東レ株式会社 | 「インドール誘導体およびその医薬用途」 |
US5994327A (en) * | 1995-11-17 | 1999-11-30 | Astra Ab | Process for the preparation of morphinans |
AR005423A1 (es) * | 1996-01-10 | 1999-06-23 | Smithkline Beecham Spa | Derivados morfinoides condensados con heterociclos (ii), su uso como sustancia terapeutica y para preparar medicamentos, composiciones farmaceuticasque los contienen y procedimiento para preparar dichos derivados. |
EP0894799B1 (en) * | 1997-01-16 | 2004-04-07 | Toray Industries, Inc. | Indolomorphinane derivatives and remedies/preventives for cerebral disorders |
TW519543B (en) | 1997-03-31 | 2003-02-01 | Toray Industries | Quinolinomorphinan derivative and pharmaceutical composition for curing-preventing cerebral disorder |
US5986141A (en) * | 1998-09-29 | 1999-11-16 | Eastman Chemical Company | Process for the production of cyclopropanemethylamine |
CA2383146C (en) * | 1999-08-24 | 2010-11-16 | Hiroshi Nagase | Therapeutic agent for neuropathic pain and neuropathic pain animal model |
US8205237B2 (en) | 2000-09-14 | 2012-06-19 | Cox Ingemar J | Identifying works, using a sub-linear time search, such as an approximate nearest neighbor search, for initiating a work-based action, such as an action on the internet |
US7232829B2 (en) | 2001-04-06 | 2007-06-19 | Regents Of The University Of Minnesota | Therapeutic compounds and methods |
CA2446351A1 (en) | 2001-05-04 | 2002-11-14 | Tularik Inc. | Fused heterocyclic compounds |
US6809104B2 (en) | 2001-05-04 | 2004-10-26 | Tularik Inc. | Fused heterocyclic compounds |
CA2474306A1 (en) * | 2002-01-25 | 2003-08-07 | Regents Of The University Of Minnesota | Selective analgesic agents |
EA009421B1 (ru) | 2002-11-06 | 2007-12-28 | Эмджен Инк. | Конденсированные гетероциклические соединения |
EP1595541A1 (en) * | 2004-05-12 | 2005-11-16 | Alcasynn Pharmaceuticals Gmbh | Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin |
EP3077398B1 (en) | 2013-12-05 | 2020-03-11 | The University of Bath | Novel opioid compounds and their uses |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3631829A1 (de) * | 1986-09-19 | 1988-07-28 | Hoechst Ag | Klonierung und verwendung des transaminase gens-tyrb |
US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
JP2906654B2 (ja) * | 1989-11-28 | 1999-06-21 | 東レ株式会社 | 免疫抑制剤及びその製造方法 |
JPH04342529A (ja) * | 1991-05-21 | 1992-11-30 | Toray Ind Inc | 抗アレルギー剤 |
US5225417A (en) * | 1992-01-21 | 1993-07-06 | G. D. Searle & Co. | Opioid agonist compounds |
US5354863A (en) * | 1992-01-21 | 1994-10-11 | G. D. Searle & Co. | Opioid agonist compounds |
US5352680A (en) * | 1992-07-15 | 1994-10-04 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists to block opioid agonist tolerance and dependence |
CA2124455C (en) * | 1992-09-29 | 2004-09-14 | Hiroshi Nagase | Indole derivatives, process for producing the same and medicinal uses of the same |
US5457208A (en) * | 1993-06-21 | 1995-10-10 | Regents Of The University Of Minnesota | Kappa opioid receptor antagonists |
JP3123080B2 (ja) * | 1995-09-26 | 2001-01-09 | 東レ株式会社 | 「インドール誘導体およびその医薬用途」 |
-
1993
- 1993-09-29 CA CA002124455A patent/CA2124455C/en not_active Expired - Fee Related
- 1993-09-29 EP EP93921084A patent/EP0614898B1/en not_active Expired - Lifetime
- 1993-09-29 JP JP50889694A patent/JP3605825B2/ja not_active Expired - Fee Related
- 1993-09-29 DE DE69332945T patent/DE69332945T2/de not_active Expired - Fee Related
- 1993-09-29 AU AU48341/93A patent/AU672033B2/en not_active Ceased
- 1993-09-29 KR KR1019940701818A patent/KR100301093B1/ko not_active IP Right Cessation
- 1993-09-29 ES ES93921084T patent/ES2199220T3/es not_active Expired - Lifetime
- 1993-09-29 WO PCT/JP1993/001388 patent/WO1994007896A1/ja active IP Right Grant
- 1993-09-29 CN CN93114196A patent/CN1043766C/zh not_active Expired - Fee Related
- 1993-09-29 AT AT93921084T patent/ATE239732T1/de not_active IP Right Cessation
- 1993-11-19 TW TW082109756A patent/TW271440B/zh active
-
1994
- 1994-05-27 FI FI942499A patent/FI942499A/fi unknown
- 1994-05-27 NO NO941977A patent/NO941977L/no unknown
-
1998
- 1998-08-18 US US09/135,580 patent/US6087369A/en not_active Expired - Fee Related
-
1999
- 1999-12-22 US US09/469,544 patent/US6291470B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0614898A4 (en) | 1994-10-12 |
KR100301093B1 (ko) | 2001-10-22 |
EP0614898A1 (en) | 1994-09-14 |
US6291470B1 (en) | 2001-09-18 |
AU672033B2 (en) | 1996-09-19 |
ES2199220T3 (es) | 2004-02-16 |
US6087369A (en) | 2000-07-11 |
CA2124455A1 (en) | 1994-04-14 |
FI942499A (fi) | 1994-07-27 |
WO1994007896A1 (en) | 1994-04-14 |
TW271440B (no) | 1996-03-01 |
FI942499A0 (fi) | 1994-05-27 |
AU4834193A (en) | 1994-04-26 |
JP3605825B2 (ja) | 2004-12-22 |
ATE239732T1 (de) | 2003-05-15 |
CA2124455C (en) | 2004-09-14 |
CN1092425A (zh) | 1994-09-21 |
CN1043766C (zh) | 1999-06-23 |
EP0614898B1 (en) | 2003-05-07 |
DE69332945T2 (de) | 2004-05-19 |
DE69332945D1 (de) | 2003-06-12 |
NO941977D0 (no) | 1994-05-27 |
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