ES8605493A1 - Un procedimiento para la preparacion de un derivado de acido 2-anilino, 6,1-dihidro-6-oxo-5-pirimidincarboxilico. - Google Patents
Un procedimiento para la preparacion de un derivado de acido 2-anilino, 6,1-dihidro-6-oxo-5-pirimidincarboxilico.Info
- Publication number
- ES8605493A1 ES8605493A1 ES546896A ES546896A ES8605493A1 ES 8605493 A1 ES8605493 A1 ES 8605493A1 ES 546896 A ES546896 A ES 546896A ES 546896 A ES546896 A ES 546896A ES 8605493 A1 ES8605493 A1 ES 8605493A1
- Authority
- ES
- Spain
- Prior art keywords
- anilino
- dihydro
- oxo
- processes
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE ACIDO 2-ANILINO-1,6-DIHIDRO-6-OXO-5-PIRIMIDINCARBOXILICO. CONSISTE EN: HACER REACCIONAR A UN DERIVADO DE N-FENILGUANIDINA DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN DISOLVENTES COMO ALCOHOLES (ETANOL, BUTANOL), HIDROCARBUROS AROMATICOS (BENCENO, TOLUENO), DIMETILSULFOXIDO O PIRIDINA, A UNA TEMPERATURA ENTRE 80J Y 200JC Y DURANTE 30 MIN A 48 HORAS, PARA OBTENER UN DERIVADO DE ACIDO 2-ANILINO-1,6-DIHIDRO-6-OXO-5-PIRIMIDINCARBOXILICO DE FORMULA (I). SIENDO: R1 Y R2, H, ALCOXI, TETRAHIDROFURILALCOXI, ALQUILO O NITRO; R3, ALQUILO; Y X, ALCOXI O DIALQUILAMINO. SE UTILIZAN PARA LA PROFILAXIS Y EL TRATAMIENTO DEL ASMA ALERGICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58207670A JPS60100559A (ja) | 1983-11-05 | 1983-11-05 | 2−アニリノ−1,6−ジヒドロ−6−オキソ−5−ピリミジンカルボン酸誘導体,その製法及び該化合物を含有する抗アレルギ−剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES546896A0 ES546896A0 (es) | 1986-03-16 |
ES8605493A1 true ES8605493A1 (es) | 1986-03-16 |
Family
ID=16543613
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537389A Expired ES8604167A1 (es) | 1983-11-05 | 1984-11-05 | Un procedimiento para la preparacion de un derivado de acido 2-anilino-1, 6-dihidro-6-oxo-5-pirimidincarboxilico |
ES546896A Expired ES8605493A1 (es) | 1983-11-05 | 1985-09-11 | Un procedimiento para la preparacion de un derivado de acido 2-anilino, 6,1-dihidro-6-oxo-5-pirimidincarboxilico. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537389A Expired ES8604167A1 (es) | 1983-11-05 | 1984-11-05 | Un procedimiento para la preparacion de un derivado de acido 2-anilino-1, 6-dihidro-6-oxo-5-pirimidincarboxilico |
Country Status (7)
Country | Link |
---|---|
US (1) | US4666915A (es) |
EP (1) | EP0144730B1 (es) |
JP (1) | JPS60100559A (es) |
AT (1) | ATE28193T1 (es) |
CA (1) | CA1218368A (es) |
DE (1) | DE3464603D1 (es) |
ES (2) | ES8604167A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8903592D0 (en) * | 1989-02-16 | 1989-04-05 | Boots Co Plc | Therapeutic agents |
EP0393723B1 (en) * | 1989-04-21 | 1997-07-16 | Asahi Kogaku Kogyo Kabushiki Kaisha | A functional paper and its use as a deodorant, filtering medium or adsorbent |
JP3465393B2 (ja) * | 1995-01-06 | 2003-11-10 | トヨタ自動車株式会社 | 内燃機関用蒸発燃料処理装置 |
AU4314000A (en) * | 1999-04-28 | 2000-11-17 | Institute Of Medicinal Molecular Design. Inc. | Heterocyclic carboxylic acid derivatives |
US7008470B2 (en) | 2000-12-25 | 2006-03-07 | Aisan Kogyo Kabushiki Kaisha | Canister |
CN1717396A (zh) * | 2002-11-28 | 2006-01-04 | 舍林股份公司 | Chk-、Pdk-和Akt-抑制嘧啶,其制备及作为药物的用途 |
ZA200707975B (en) * | 2005-05-06 | 2008-11-26 | Du Pont | Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids |
JP4918259B2 (ja) * | 2006-01-06 | 2012-04-18 | 株式会社キャタラー | 低分子有機ガス吸収材及びこれを用いた燃料蒸気処理装置 |
EP2841070B1 (en) * | 2012-04-24 | 2018-07-25 | Board Of Trustees Of Northern Illinois University | Design and synthesis of novel inhibitors of isoprenoid biosynthesis |
US10155766B2 (en) | 2016-06-14 | 2018-12-18 | Board Of Trustees Of Northern Illinois University | Pyrazolopyrimidine antibacterial agents |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB859716A (en) * | 1957-07-12 | 1961-01-25 | Cilag Chemie | New pyrimidines and their salts and a process for their production |
CH376115A (de) * | 1957-12-06 | 1964-03-31 | Ciba Geigy | Verfahren zur Herstellung neuer substituierter Pyrimidine |
DE1670537A1 (de) * | 1966-11-09 | 1970-10-29 | Degussa | Verfahren zur Herstellung neuer substituierter Aminopyrimidine |
US3917835A (en) * | 1972-10-24 | 1975-11-04 | Pfizer | A method of preventing asthmatic symptoms |
US3883653A (en) * | 1972-10-24 | 1975-05-13 | Pfizer | Method of preventing asthmatic symptoms |
US3968213A (en) * | 1972-10-24 | 1976-07-06 | Pfizer Inc. | Method of preventing asthmatic symptoms |
US3957784A (en) * | 1972-10-24 | 1976-05-18 | Pfizer Inc. | Bis(4-[4'-hydroxy-5'-carboxy-2'-pyrimidinyl]phenoxy)alkanes |
US4031093A (en) * | 1975-09-09 | 1977-06-21 | Bristol-Myers Company | 1,6-Dihydro-6-oxo-2-(ortho-substituted phenyl)pyrimidine-5-carboxylic acid derivatives |
DE2735919A1 (de) * | 1977-08-10 | 1979-02-22 | Boehringer Sohn Ingelheim | Neue 2-pyridyl- und 2-pyrimidylaminobenzoesaeuren |
-
1983
- 1983-11-05 JP JP58207670A patent/JPS60100559A/ja active Granted
-
1984
- 1984-11-02 DE DE8484113185T patent/DE3464603D1/de not_active Expired
- 1984-11-02 CA CA000466984A patent/CA1218368A/en not_active Expired
- 1984-11-02 AT AT84113185T patent/ATE28193T1/de not_active IP Right Cessation
- 1984-11-02 EP EP84113185A patent/EP0144730B1/en not_active Expired
- 1984-11-05 US US06/668,304 patent/US4666915A/en not_active Expired - Fee Related
- 1984-11-05 ES ES537389A patent/ES8604167A1/es not_active Expired
-
1985
- 1985-09-11 ES ES546896A patent/ES8605493A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0144730B1 (en) | 1987-07-08 |
JPH0336835B2 (es) | 1991-06-03 |
EP0144730A1 (en) | 1985-06-19 |
ES537389A0 (es) | 1986-01-16 |
JPS60100559A (ja) | 1985-06-04 |
CA1218368A (en) | 1987-02-24 |
ES546896A0 (es) | 1986-03-16 |
US4666915A (en) | 1987-05-19 |
ES8604167A1 (es) | 1986-01-16 |
ATE28193T1 (de) | 1987-07-15 |
DE3464603D1 (en) | 1987-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |