ES2001893A6 - Procedimiento para la obtencion de derivados de metilendioxifenantreno - Google Patents

Procedimiento para la obtencion de derivados de metilendioxifenantreno

Info

Publication number
ES2001893A6
ES2001893A6 ES8601409A ES8601409A ES2001893A6 ES 2001893 A6 ES2001893 A6 ES 2001893A6 ES 8601409 A ES8601409 A ES 8601409A ES 8601409 A ES8601409 A ES 8601409A ES 2001893 A6 ES2001893 A6 ES 2001893A6
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
methylendioxyphenathrene
therapeutic applications
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601409A
Other languages
English (en)
Inventor
Klaus Gorler
Gunter Krumbiegel
M Hanack
L Suramanian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Dr Madaus GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co
Publication of ES2001893A6 publication Critical patent/ES2001893A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE METILENDIOXIFENANTRENO, DE FORMULA GENERAL (I), EN DONDE R1 SIGNIFICA UN ATOMO DE HIDROGENO, METOXI O ETOXI, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SE HACE REACCIONAR EL 6 BROMO-BROMURO DE PIPERONILO, DE FORMULA (III), CON TRIFENILFOSFINA, EN UN DISOLVENTE ORGANICO ANHIDRO, OBTENIENDOSE LA SAL DE FOSFONIO. ESTA SE HACE REACCIONAR, EN PRESENCIA DE UNA BASE FUERTE, CON BENZALDEHIDO, O-METOXI-BENZALDEHIDO U ORTO-ETOXI-BENZALDEHIDO, OBTENIENDOSE UN ESTILBENO DE FORMULA (IV). ESTE BROMURO DE ESTILBENO SE PASA A ACIDO DE FORMULA (I) VIA NITRILO, EN PRESENCIA DE UN DISOLVENTE POLAR APROTICO, O POR REACCION CON N-BUTIL-LITIO Y DIOXIDO DE CARBONO, O POR RADIACION UV. ESTOS COMPUESTOS SON MUY ADECUADOS PARA LA PROFILAXIS Y TERAPEUTICA DE ENFERMEDADES INFECCIOSAS.
ES8601409A 1985-08-28 1986-08-27 Procedimiento para la obtencion de derivados de metilendioxifenantreno Expired ES2001893A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853530718 DE3530718A1 (de) 1985-08-28 1985-08-28 Methylendioxyphenanthren- und -stilbenderivate, verfahren zur herstellung derselben und arzneimittel, die diese enthalten

Publications (1)

Publication Number Publication Date
ES2001893A6 true ES2001893A6 (es) 1988-07-01

Family

ID=6279566

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601409A Expired ES2001893A6 (es) 1985-08-28 1986-08-27 Procedimiento para la obtencion de derivados de metilendioxifenantreno

Country Status (27)

Country Link
US (2) US4835178A (es)
JP (1) JPS62167776A (es)
KR (1) KR880000179B1 (es)
AR (1) AR242568A1 (es)
AT (1) AT398568B (es)
BE (1) BE905340A (es)
CH (1) CH673457A5 (es)
DD (1) DD266800A5 (es)
DE (1) DE3530718A1 (es)
DK (1) DK168705B1 (es)
ES (1) ES2001893A6 (es)
FI (1) FI92396C (es)
FR (1) FR2586681B1 (es)
GB (1) GB2179347B (es)
HU (3) HU199446B (es)
IE (1) IE59239B1 (es)
IT (1) IT1197467B (es)
LU (1) LU86556A1 (es)
MX (2) MX172917B (es)
NL (1) NL8602127A (es)
NO (1) NO863434L (es)
PL (2) PL154026B1 (es)
PT (1) PT83258B (es)
SE (1) SE465153B (es)
SU (1) SU1731053A3 (es)
YU (2) YU44061B (es)
ZA (1) ZA866487B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE432983T1 (de) * 1989-12-15 1992-03-19 Pharma Mar, S.A., Madrid, Es Neue verbindungen des diterpentyps.
DE69106493T2 (de) * 1991-02-05 1995-06-29 Merrell Dow Pharma Sulfonische Stilbenderivate zur Behandlung von Viruserkrankungen.
CA2130360C (en) * 1992-02-20 1998-06-09 Allan D. Cardin Sulfonic acid derivatives in the treatment of viral diseases
US5334615A (en) * 1992-12-17 1994-08-02 Walles Wilhelm E Oil with bactericidal and virucidal properties
US5739166A (en) * 1994-11-29 1998-04-14 G.D. Searle & Co. Substituted terphenyl compounds for the treatment of inflammation
CN112778264B (zh) * 2021-01-21 2023-09-15 江西农业大学 马兜铃次酸衍生物及其在制备抗炎药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4122092A (en) * 1977-08-25 1978-10-24 University Of Rochester Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone
JPS57106677A (en) * 1980-12-22 1982-07-02 Kureha Chem Ind Co Ltd N-(3,4-methylenedioxybenzylidene) aminomethylcyclohexane-carboxylic acid, and salt of said carboxylic acid

Also Published As

Publication number Publication date
HU202104B (en) 1991-02-28
YU43998B (en) 1990-02-28
PL261196A1 (en) 1988-02-04
DE3530718C2 (es) 1992-07-09
JPS62167776A (ja) 1987-07-24
PL154026B1 (en) 1991-06-28
GB2179347B (en) 1989-08-09
GB8619644D0 (en) 1986-09-24
NO863434D0 (no) 1986-08-27
PL148757B1 (en) 1989-11-30
YU44061B (en) 1990-02-28
ZA866487B (en) 1987-04-29
CH673457A5 (es) 1990-03-15
AR242568A1 (es) 1993-04-30
YU147586A (en) 1988-02-29
AT398568B (de) 1994-12-27
GB2179347A (en) 1987-03-04
HUT44775A (en) 1988-04-28
YU114987A (en) 1988-02-29
IE59239B1 (en) 1994-01-26
SE8603589L (sv) 1987-03-01
PT83258A (de) 1986-09-01
FI863282A (fi) 1987-03-01
FR2586681A1 (fr) 1987-03-06
MX3550A (es) 1993-10-01
FI92396B (fi) 1994-07-29
IT1197467B (it) 1988-11-30
MX172917B (es) 1994-01-21
IE862288L (en) 1987-02-28
PT83258B (pt) 1988-07-01
FR2586681B1 (fr) 1991-02-22
ATA215186A (de) 1994-05-15
FI863282A0 (fi) 1986-08-13
JPH0349908B2 (es) 1991-07-31
MX9300436A (es) 1994-07-29
KR870002119A (ko) 1987-03-30
FI92396C (fi) 1994-11-10
SE465153B (sv) 1991-08-05
NL8602127A (nl) 1987-03-16
DD266800A5 (de) 1989-04-12
DK407586A (da) 1987-03-01
LU86556A1 (fr) 1986-12-02
HU199446B (en) 1990-02-28
BE905340A (fr) 1987-02-27
SE8603589D0 (sv) 1986-08-26
DK168705B1 (da) 1994-05-24
NO863434L (no) 1987-03-02
KR880000179B1 (ko) 1988-03-12
DE3530718A1 (de) 1987-03-12
PL268178A1 (en) 1988-10-13
US4835178A (en) 1989-05-30
IT8621526A0 (it) 1986-08-26
HU895304D0 (en) 1990-03-28
US5024743A (en) 1991-06-18
DK407586D0 (da) 1986-08-27
SU1731053A3 (ru) 1992-04-30

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