NO954681L - Kjemiske forbindelser - Google Patents

Kjemiske forbindelser

Info

Publication number
NO954681L
NO954681L NO954681A NO954681A NO954681L NO 954681 L NO954681 L NO 954681L NO 954681 A NO954681 A NO 954681A NO 954681 A NO954681 A NO 954681A NO 954681 L NO954681 L NO 954681L
Authority
NO
Norway
Prior art keywords
zero
group
rsome
integers
electron
Prior art date
Application number
NO954681A
Other languages
English (en)
Other versions
NO954681D0 (no
Inventor
Peter Clive Cherry
John Derek Cocker
Andrew David Searle
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO954681D0 publication Critical patent/NO954681D0/no
Publication of NO954681L publication Critical patent/NO954681L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Oppfinnelsen vedrører "substituerte karbazol-derivater, fremgangsmåter for deres fremstilling, farmasøytiske blandinger som inneholder slike og deres medisinske anvendelse for reduksjon av østrogen- og/eller androgen-nivåer.Spesielle forbindelser ifølge oppfinnelsen er forbindelser med formel (I). hvor Rx og Ruavhengig av hverandre, utgjør et hydrogenatom eller en C-alkylgruppe; hver av Rsom kan være like eller forskjellige, utgjør en elektron-tiltrekkende gruppe; hver av Rsom kan være like eller forskjellige, utgjør en elektron-tiltrekkende gruppe; Rer en gruppe med formel. er et halogenatom, en C-alkylgruppe eller en C^-alkoksy-gruppe;. i m er null eller et av heltallene 1 til 4;. n er null eller et av heltallene 1 til 3; og p er null, 1 eller 2. og farmasøytisk akseptable salter og solvater derav.
NO954681A 1993-05-21 1995-11-20 Kjemiske forbindelser NO954681L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939310635A GB9310635D0 (en) 1993-05-21 1993-05-21 Chemical compounds
PCT/EP1994/001613 WO1994027989A1 (en) 1993-05-21 1994-05-19 Carbazole derivatives with 17,20-lyase-inhibiting activity

Publications (2)

Publication Number Publication Date
NO954681D0 NO954681D0 (no) 1995-11-20
NO954681L true NO954681L (no) 1995-11-20

Family

ID=10736007

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954681A NO954681L (no) 1993-05-21 1995-11-20 Kjemiske forbindelser

Country Status (19)

Country Link
EP (1) EP0699196A1 (no)
JP (1) JPH08510455A (no)
CN (1) CN1126473A (no)
AU (1) AU6928794A (no)
BG (1) BG100154A (no)
CA (1) CA2162921A1 (no)
CZ (1) CZ305195A3 (no)
FI (1) FI955587A0 (no)
GB (1) GB9310635D0 (no)
HU (1) HUT73790A (no)
IL (1) IL109703A0 (no)
NO (1) NO954681L (no)
OA (1) OA10195A (no)
PE (1) PE31195A1 (no)
PL (1) PL311702A1 (no)
SK (1) SK142495A3 (no)
TW (1) TW279866B (no)
WO (1) WO1994027989A1 (no)
ZA (1) ZA943494B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960704852A (ko) * 1993-09-30 1996-10-09 오노다 마사요시 아졸 유도체 및 이의 약제학적 조성물 (Azole derivative and pharmaceutical composition thereof)
AU3846395A (en) * 1994-11-07 1996-05-31 Janssen Pharmaceutica N.V. Compositions comprising carbazoles and cyclodextrins
AU702406B2 (en) * 1995-03-01 1999-02-18 Yamanouchi Pharmaceutical Co., Ltd. Imidazole derivatives and medicinal composition thereof
CN1251577A (zh) * 1997-02-21 2000-04-26 武田药品工业株式会社 稠环化合物及其生产和应用
EP1681290B9 (en) 2000-11-17 2013-06-19 Takeda Pharmaceutical Company Limited Imidazole derivatives, production method thereof and use thereof
EP1344777B1 (en) 2000-11-20 2011-03-16 Takeda Pharmaceutical Company Limited Imidazole derivatives, process for their preparation and their use
US7067537B2 (en) 2000-12-08 2006-06-27 Takeda Pharmaceutical Company Limited Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
CA2612723A1 (en) * 2005-06-24 2007-01-04 Eli Lilly And Company Tetrahydrocarbazole derivatives useful as androgen receptor modulators
GB0525323D0 (en) * 2005-12-13 2006-01-18 Sterix Ltd Compound
US8093279B2 (en) 2005-12-13 2012-01-10 Gillian Reed, legal representative Compound
CN100586932C (zh) * 2007-01-26 2010-02-03 中国医学科学院医药生物技术研究所 抗肿瘤化合物及其制备方法
CA2765983C (en) 2009-06-26 2017-11-14 Novartis Ag 1,3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
EP2531029B1 (en) * 2010-02-04 2016-10-19 Radius Health, Inc. Selective androgen receptor modulators
SI2568806T1 (sl) 2010-05-12 2016-09-30 Radius Health, Inc. Režimi zdravljenja
WO2012018948A2 (en) 2010-08-04 2012-02-09 Pellficure Pharmaceuticals, Inc. Novel treatment of prostate carcinoma
US8946260B2 (en) 2010-09-16 2015-02-03 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
AU2011312490B2 (en) 2010-09-28 2015-06-25 Radius Pharmaceuticals, Inc. Selective androgen receptor modulators
BR112013027395A2 (pt) 2011-04-28 2017-01-17 Novartis Ag inibidores de 17alfa-hidroxilase/c17,20-liase
US9492460B2 (en) * 2013-02-27 2016-11-15 Bristol-Myers Squibb Company Carbazole compounds useful as bromodomain inhibitors
CA2902335C (en) 2013-03-14 2021-09-14 Pellficure Pharmaceuticals, Inc. Novel therapy for prostate carcinoma
SI3122426T1 (sl) 2014-03-28 2023-04-28 Duke University Zdravljenje raka dojk z uporabo selektivnih modulatorjev estrogenskih receptorjev
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
EP3191087A1 (en) 2014-09-12 2017-07-19 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
DK3474841T3 (da) 2016-06-22 2022-05-09 Ellipses Pharma Ltd Fremgangsmåder til behandling af ar+-brystkræft
WO2018080933A1 (en) 2016-10-24 2018-05-03 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione
KR20230109795A (ko) 2017-01-05 2023-07-20 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
AU6928794A (en) 1994-12-20
ZA943494B (en) 1995-01-23
CA2162921A1 (en) 1994-12-08
BG100154A (en) 1996-07-31
PE31195A1 (es) 1995-10-18
JPH08510455A (ja) 1996-11-05
PL311702A1 (en) 1996-03-04
FI955587A (fi) 1995-11-20
SK142495A3 (en) 1996-06-05
IL109703A0 (en) 1994-08-26
OA10195A (en) 1996-12-18
GB9310635D0 (en) 1993-07-07
HU9503321D0 (en) 1996-01-29
CN1126473A (zh) 1996-07-10
EP0699196A1 (en) 1996-03-06
NO954681D0 (no) 1995-11-20
FI955587A0 (fi) 1995-11-20
WO1994027989A1 (en) 1994-12-08
HUT73790A (en) 1996-09-30
CZ305195A3 (en) 1996-06-12
TW279866B (no) 1996-07-01

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