NO954681L - Kjemiske forbindelser - Google Patents
Kjemiske forbindelserInfo
- Publication number
- NO954681L NO954681L NO954681A NO954681A NO954681L NO 954681 L NO954681 L NO 954681L NO 954681 A NO954681 A NO 954681A NO 954681 A NO954681 A NO 954681A NO 954681 L NO954681 L NO 954681L
- Authority
- NO
- Norway
- Prior art keywords
- zero
- group
- rsome
- integers
- electron
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Oppfinnelsen vedrører "substituerte karbazol-derivater, fremgangsmåter for deres fremstilling, farmasøytiske blandinger som inneholder slike og deres medisinske anvendelse for reduksjon av østrogen- og/eller androgen-nivåer.Spesielle forbindelser ifølge oppfinnelsen er forbindelser med formel (I). hvor Rx og Ruavhengig av hverandre, utgjør et hydrogenatom eller en C-alkylgruppe; hver av Rsom kan være like eller forskjellige, utgjør en elektron-tiltrekkende gruppe; hver av Rsom kan være like eller forskjellige, utgjør en elektron-tiltrekkende gruppe; Rer en gruppe med formel. er et halogenatom, en C-alkylgruppe eller en C^-alkoksy-gruppe;. i m er null eller et av heltallene 1 til 4;. n er null eller et av heltallene 1 til 3; og p er null, 1 eller 2. og farmasøytisk akseptable salter og solvater derav.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939310635A GB9310635D0 (en) | 1993-05-21 | 1993-05-21 | Chemical compounds |
PCT/EP1994/001613 WO1994027989A1 (en) | 1993-05-21 | 1994-05-19 | Carbazole derivatives with 17,20-lyase-inhibiting activity |
Publications (2)
Publication Number | Publication Date |
---|---|
NO954681L true NO954681L (no) | 1995-11-20 |
NO954681D0 NO954681D0 (no) | 1995-11-20 |
Family
ID=10736007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO954681A NO954681D0 (no) | 1993-05-21 | 1995-11-20 | Kjemiske forbindelser |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0699196A1 (no) |
JP (1) | JPH08510455A (no) |
CN (1) | CN1126473A (no) |
AU (1) | AU6928794A (no) |
BG (1) | BG100154A (no) |
CA (1) | CA2162921A1 (no) |
CZ (1) | CZ305195A3 (no) |
FI (1) | FI955587A0 (no) |
GB (1) | GB9310635D0 (no) |
HU (1) | HUT73790A (no) |
IL (1) | IL109703A0 (no) |
NO (1) | NO954681D0 (no) |
OA (1) | OA10195A (no) |
PE (1) | PE31195A1 (no) |
PL (1) | PL311702A1 (no) |
SK (1) | SK142495A3 (no) |
TW (1) | TW279866B (no) |
WO (1) | WO1994027989A1 (no) |
ZA (1) | ZA943494B (no) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2170874A1 (en) * | 1993-09-30 | 1995-04-06 | Minoru Okada | Azole derivative and pharmaceutical composition thereof |
WO1996014090A1 (en) * | 1994-11-07 | 1996-05-17 | Janssen Pharmaceutica N.V. | Compositions comprising carbazoles and cyclodextrins |
WO1996026927A1 (fr) * | 1995-03-01 | 1996-09-06 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'imidazole et composition medicinale a base desdits derives |
WO1998037070A1 (fr) * | 1997-02-21 | 1998-08-27 | Takeda Chemical Industries, Ltd. | Composes a anneaux condenses, leur procede de production et leur utilisation |
MY134929A (en) | 2000-11-17 | 2008-01-31 | Takeda Pharmaceutical | Novel imidazole derivatives, production method thereof and use thereof |
EP1344777B1 (en) | 2000-11-20 | 2011-03-16 | Takeda Pharmaceutical Company Limited | Imidazole derivatives, process for their preparation and their use |
EP1348706B1 (en) | 2000-12-08 | 2009-08-19 | Takeda Pharmaceutical Company Limited | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
BRPI0611705A2 (pt) * | 2005-06-24 | 2016-11-16 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto |
GB0525323D0 (en) | 2005-12-13 | 2006-01-18 | Sterix Ltd | Compound |
US8093279B2 (en) | 2005-12-13 | 2012-01-10 | Gillian Reed, legal representative | Compound |
CN100586932C (zh) * | 2007-01-26 | 2010-02-03 | 中国医学科学院医药生物技术研究所 | 抗肿瘤化合物及其制备方法 |
DK2445903T3 (da) | 2009-06-26 | 2014-06-23 | Novartis Ag | 1,3-Disubstituerede imidazolidin-2-on-derivater som CYP17-inhibitorer |
EP2531029B1 (en) * | 2010-02-04 | 2016-10-19 | Radius Health, Inc. | Selective androgen receptor modulators |
ME02474B (me) | 2010-05-12 | 2017-02-20 | Radius Health Inc | Terapijski režimi |
KR101594660B1 (ko) | 2010-08-04 | 2016-02-16 | 펠피큐어 파마슈티걸즈 아이엔씨 | 전립선 암종의 치료를 위한 병용 요법 |
WO2012035078A1 (en) | 2010-09-16 | 2012-03-22 | Novartis Ag | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS |
BR112013007685B1 (pt) | 2010-09-28 | 2021-11-09 | Radius Pharmaceuticals, Inc | Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto |
CN103649073B (zh) | 2011-04-28 | 2016-04-13 | 诺瓦提斯公司 | 17α-羟化酶/C17,20-裂合酶抑制剂 |
US9492460B2 (en) * | 2013-02-27 | 2016-11-15 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
US20160022606A1 (en) | 2013-03-14 | 2016-01-28 | Pellficure Pharmaceuticals Inc. | Novel therapy for prostate carcinoma |
EP4035664A3 (en) | 2014-03-28 | 2022-11-30 | Duke University | Treating cancer using selective estrogen receptor modulators |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
WO2016040896A1 (en) | 2014-09-12 | 2016-03-17 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
RU2769527C2 (ru) | 2016-06-22 | 2022-04-01 | Эллипсес Фарма Лтд | Способы лечения ar+ рака молочной железы |
CA3044812A1 (en) | 2016-10-24 | 2018-05-03 | Pellficure Pharmaceuticals Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1,4-dione |
KR102322802B1 (ko) | 2017-01-05 | 2021-11-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS229934B2 (en) * | 1981-07-07 | 1984-07-16 | Pfizer | Production method subst.indolylacryte acid derivative |
GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
-
1993
- 1993-05-21 GB GB939310635A patent/GB9310635D0/en active Pending
-
1994
- 1994-05-02 ZA ZA943494A patent/ZA943494B/xx unknown
- 1994-05-17 TW TW083104441A patent/TW279866B/zh active
- 1994-05-19 SK SK1424-95A patent/SK142495A3/sk unknown
- 1994-05-19 AU AU69287/94A patent/AU6928794A/en not_active Abandoned
- 1994-05-19 WO PCT/EP1994/001613 patent/WO1994027989A1/en not_active Application Discontinuation
- 1994-05-19 HU HU9503321A patent/HUT73790A/hu unknown
- 1994-05-19 CZ CZ953051A patent/CZ305195A3/cs unknown
- 1994-05-19 CN CN94192683A patent/CN1126473A/zh active Pending
- 1994-05-19 PL PL94311702A patent/PL311702A1/xx unknown
- 1994-05-19 CA CA002162921A patent/CA2162921A1/en not_active Abandoned
- 1994-05-19 EP EP94917647A patent/EP0699196A1/en not_active Withdrawn
- 1994-05-19 JP JP7500181A patent/JPH08510455A/ja active Pending
- 1994-05-20 IL IL10970394A patent/IL109703A0/xx unknown
- 1994-11-18 PE PE1994255110A patent/PE31195A1/es not_active Application Discontinuation
-
1995
- 1995-11-17 OA OA60742A patent/OA10195A/en unknown
- 1995-11-20 NO NO954681A patent/NO954681D0/no unknown
- 1995-11-20 FI FI955587A patent/FI955587A0/fi not_active Application Discontinuation
- 1995-11-21 BG BG100154A patent/BG100154A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JPH08510455A (ja) | 1996-11-05 |
PL311702A1 (en) | 1996-03-04 |
EP0699196A1 (en) | 1996-03-06 |
TW279866B (no) | 1996-07-01 |
AU6928794A (en) | 1994-12-20 |
IL109703A0 (en) | 1994-08-26 |
OA10195A (en) | 1996-12-18 |
GB9310635D0 (en) | 1993-07-07 |
FI955587A (fi) | 1995-11-20 |
HUT73790A (en) | 1996-09-30 |
NO954681D0 (no) | 1995-11-20 |
CN1126473A (zh) | 1996-07-10 |
ZA943494B (en) | 1995-01-23 |
CA2162921A1 (en) | 1994-12-08 |
PE31195A1 (es) | 1995-10-18 |
WO1994027989A1 (en) | 1994-12-08 |
HU9503321D0 (en) | 1996-01-29 |
BG100154A (en) | 1996-07-31 |
CZ305195A3 (en) | 1996-06-12 |
SK142495A3 (en) | 1996-06-05 |
FI955587A0 (fi) | 1995-11-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO954681L (no) | Kjemiske forbindelser | |
DK0794949T3 (da) | Hidtil ukendte 3,5-dioxo-(2H,4H)-1,2,4-triazinderivater, fremstilling heraf og deres anvendelse som lægemidler | |
HUP0401009A2 (hu) | 5-Hidroxitriptamin-6-ligandumokként alkalmazható 1-aril- vagy 1- alkil-szulfonilbenzazol-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
MY119150A (en) | Azetidine derivatives, their preparation and medicaments containing them | |
ES8203883A1 (es) | Un procedimiento para la preparacion de derivados de imida- zol | |
NO986055D0 (no) | Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat | |
HUP0402225A2 (hu) | Makrolid-vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
NO20022558L (no) | 4-karboksyamino-2-etyl-1,2,3,4-tetrahydrokinolinkrystall som CETP inhibitor | |
HUT67788A (en) | 2,4-dioxo-thiazolidine derivatives, their preparation and pharmaceutical compositions containing them | |
HK1052697A1 (en) | Novel benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing same. | |
HU9204121D0 (en) | Thiazolidine derivatives containing quinone group, method for producing them and medical preparatives containing these compounds | |
IE872658L (en) | Tetrahydroquinoline derivatives, a process for their preparation, their use and pharmaceutical formulations containing them | |
ES2005582A6 (es) | Procedimiento de obtencion de nuevos derivados de la 1-(hidroxiestiril)-5h-2,3-benzodiazepina. | |
ES8605760A1 (es) | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dietilaminoalcoxi sustituido y sus sales deadicion acidas y amonicas cuaternarias | |
NO882334L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive alkansulfonanilid-derivater. | |
AU649099B2 (en) | Use of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine derivatives as free radical scavengers | |
DK661088A (da) | N-(23-vinblastinoyl)derivater af 1-aminomethylphosphonsyre, fremgangsmaade til deres fremstilling og farmaceutiske midelr indeholdende dem | |
HUP9701479A2 (hu) | Hidrolizáló csoportot tartalmazó N-benzil-azolium-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények | |
ES2001893A6 (es) | Procedimiento para la obtencion de derivados de metilendioxifenantreno | |
HUP0202647A2 (hu) | Új arilalkanoilszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények | |
HUP0202438A2 (hu) | Dioxo-tiazolidin-származékok és ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
WO1987007609A1 (en) | 1,1,2-triaryl-1-butene derivatives | |
IT1150955B (it) | Derivati 3h-naft(1.2-d)-imidazolici il procedimento per la loro preparazione, il loro uso come agenti antiinfiammatori e le composizioni farmaceutiche che li contengono | |
NO20035026D0 (no) | Dihydroimidazo [5,1-A]-<beta>-karbolinderivater, fremgangsmåte til deres fremstilling og anvendelse derav som legemiddel | |
NO20010801L (no) | Nye 6-amino- eller 6-hydroazino-sulfonyl-3- kinolynylfosfonsyreforbindelse, fremgangsmåte ved deresfremstilling og farmasöytiske sammensetninger inneholdende dem |