BG100154A - Carbazole derivatibes having inhibiting effect to 17,20-lyase - Google Patents

Carbazole derivatibes having inhibiting effect to 17,20-lyase

Info

Publication number
BG100154A
BG100154A BG100154A BG10015495A BG100154A BG 100154 A BG100154 A BG 100154A BG 100154 A BG100154 A BG 100154A BG 10015495 A BG10015495 A BG 10015495A BG 100154 A BG100154 A BG 100154A
Authority
BG
Bulgaria
Prior art keywords
group
derivatibes
lyase
carbazole
mean
Prior art date
Application number
BG100154A
Other languages
Bulgarian (bg)
Inventor
Peter Cherry
John Cocker
Andrew Searle
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of BG100154A publication Critical patent/BG100154A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to substituted carbazole derivatives, to their pharmaceutically acceptable salts and solvate forms, to methods for their preparation, to the pharmaceutical compositions containing them and to their application in medicine for reducing the level of esterogens and/or androgens. The compounds have the formula where R1 and R4 mean, independent form each other, hydrogen atom or C1-6 alkyl group, all R2 substituents can be the same or different and mean electron-acceptor group, all R3 substituets can be the same or different and mean electron-acceptor group, R5 being a group having the formula R6 is halogen atom, C1-6 alkyl group or C1-6 alkoxygroup; m has the value of 0 or an integer from 1 to 4; n - 0 or an integer form 1 to 3 and p is 0,1 or 2.
BG100154A 1993-05-21 1995-11-21 Carbazole derivatibes having inhibiting effect to 17,20-lyase BG100154A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939310635A GB9310635D0 (en) 1993-05-21 1993-05-21 Chemical compounds
PCT/EP1994/001613 WO1994027989A1 (en) 1993-05-21 1994-05-19 Carbazole derivatives with 17,20-lyase-inhibiting activity

Publications (1)

Publication Number Publication Date
BG100154A true BG100154A (en) 1996-07-31

Family

ID=10736007

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100154A BG100154A (en) 1993-05-21 1995-11-21 Carbazole derivatibes having inhibiting effect to 17,20-lyase

Country Status (19)

Country Link
EP (1) EP0699196A1 (en)
JP (1) JPH08510455A (en)
CN (1) CN1126473A (en)
AU (1) AU6928794A (en)
BG (1) BG100154A (en)
CA (1) CA2162921A1 (en)
CZ (1) CZ305195A3 (en)
FI (1) FI955587A0 (en)
GB (1) GB9310635D0 (en)
HU (1) HUT73790A (en)
IL (1) IL109703A0 (en)
NO (1) NO954681D0 (en)
OA (1) OA10195A (en)
PE (1) PE31195A1 (en)
PL (1) PL311702A1 (en)
SK (1) SK142495A3 (en)
TW (1) TW279866B (en)
WO (1) WO1994027989A1 (en)
ZA (1) ZA943494B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT75871A (en) * 1993-09-30 1997-05-28 Yamanouchi Co Azole derivatives and pharmaceutical compositions thereof
WO1996014090A1 (en) * 1994-11-07 1996-05-17 Janssen Pharmaceutica N.V. Compositions comprising carbazoles and cyclodextrins
EP0820989A4 (en) * 1995-03-01 1998-05-06 Yamanouchi Pharma Co Ltd Imidazole derivatives and medicinal composition thereof
ATE231128T1 (en) * 1997-02-21 2003-02-15 Takeda Chemical Industries Ltd JOINTS WITH CONDENSED RINGS, METHOD FOR THEIR PRODUCTION AND THEIR APPLICATION
CN1329394C (en) 2000-11-17 2007-08-01 武田药品工业株式会社 Novel imidazole derivatives, production method thereof and use thereof
US6960586B2 (en) 2000-11-20 2005-11-01 Takeda Pharmaceutical Company Limited Imidazole derivatives, process for their preparation and their use
ATE440096T1 (en) 2000-12-08 2009-09-15 Takeda Pharmaceutical SUBSTITUTED THIAZOLE DERIVATIVES WITH 3-PYRIDYL GROUPS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
CN101203491A (en) 2005-06-24 2008-06-18 伊莱利利公司 Tetrahydrocarbazole derivatives used as androgen receptor modifier
US8093279B2 (en) 2005-12-13 2012-01-10 Gillian Reed, legal representative Compound
GB0525323D0 (en) * 2005-12-13 2006-01-18 Sterix Ltd Compound
CN100586932C (en) * 2007-01-26 2010-02-03 中国医学科学院医药生物技术研究所 Antitumor compound and its preparation process
JO2892B1 (en) 2009-06-26 2015-09-15 نوفارتيس ايه جي Inhibitors of cyp 17
AU2011212813B2 (en) 2010-02-04 2014-10-23 Radius Health, Inc. Selective androgen receptor modulators
ME02474B (en) 2010-05-12 2017-02-20 Radius Health Inc Therapeutic regimens
WO2012018948A2 (en) 2010-08-04 2012-02-09 Pellficure Pharmaceuticals, Inc. Novel treatment of prostate carcinoma
WO2012035078A1 (en) 2010-09-16 2012-03-22 Novartis Ag 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
US9133182B2 (en) 2010-09-28 2015-09-15 Radius Health, Inc. Selective androgen receptor modulators
WO2012149413A1 (en) 2011-04-28 2012-11-01 Novartis Ag 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
US9492460B2 (en) * 2013-02-27 2016-11-15 Bristol-Myers Squibb Company Carbazole compounds useful as bromodomain inhibitors
CA2902335C (en) 2013-03-14 2021-09-14 Pellficure Pharmaceuticals, Inc. Novel therapy for prostate carcinoma
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
ES2939940T3 (en) 2014-03-28 2023-04-28 Univ Duke Treatment of breast cancer using selective estrogen receptor modulators
US10093620B2 (en) 2014-09-12 2018-10-09 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
JP7221699B2 (en) 2016-06-22 2023-02-14 エリプセス ファーマ エルティーディー AR+ methods of treating breast cancer
WO2018080933A1 (en) 2016-10-24 2018-05-03 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione
FI3565542T3 (en) 2017-01-05 2024-06-24 Radius Pharmaceuticals Inc Polymorphic forms of rad1901-2hcl

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
FI955587A (en) 1995-11-20
PL311702A1 (en) 1996-03-04
GB9310635D0 (en) 1993-07-07
FI955587A0 (en) 1995-11-20
IL109703A0 (en) 1994-08-26
OA10195A (en) 1996-12-18
CZ305195A3 (en) 1996-06-12
HUT73790A (en) 1996-09-30
CN1126473A (en) 1996-07-10
CA2162921A1 (en) 1994-12-08
NO954681L (en) 1995-11-20
TW279866B (en) 1996-07-01
NO954681D0 (en) 1995-11-20
WO1994027989A1 (en) 1994-12-08
AU6928794A (en) 1994-12-20
HU9503321D0 (en) 1996-01-29
ZA943494B (en) 1995-01-23
PE31195A1 (en) 1995-10-18
EP0699196A1 (en) 1996-03-06
JPH08510455A (en) 1996-11-05
SK142495A3 (en) 1996-06-05

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