PE31195A1 - Derivado de carbazol sustituido, proceso para su preparacion y composicion farmaceutica que lo contiene - Google Patents

Derivado de carbazol sustituido, proceso para su preparacion y composicion farmaceutica que lo contiene

Info

Publication number
PE31195A1
PE31195A1 PE1994255110A PE25511094A PE31195A1 PE 31195 A1 PE31195 A1 PE 31195A1 PE 1994255110 A PE1994255110 A PE 1994255110A PE 25511094 A PE25511094 A PE 25511094A PE 31195 A1 PE31195 A1 PE 31195A1
Authority
PE
Peru
Prior art keywords
preparation
pharmaceutical composition
piridin
ilo
alkyl
Prior art date
Application number
PE1994255110A
Other languages
English (en)
Inventor
Peter Clive Cherry
Andrew David Searle
John Derek Cocker
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE31195A1 publication Critical patent/PE31195A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: 1) R1 Y R4 SON ATOMOS DE HIDROGENO, ALQUILO C1-C6; 2) R2 Y R3 SON GRUPOS QUE RETIRAN ELECTRONES TAL COMO HALOGENOS, NITRILO, NITRO, TRIFLUOROMETILO, ALDEHIDO, CETO, ACIDO CARBOXILICO, ETER CARBOXILICO; 3) R5 ES UN ANILLO HETEROCICLICO CONTENIENDO NITROGENO QUE PUEDE ESTAR SUSTITUIDO POR (R6)p, DE PREFERENCIA R5 ES PIRIDIN-3-ILO, PIRIDIN-4-ILO; 4) R6 ES UN HALOGENO, ALQUILO C1-C6, ALCOXI C1-C6; 5) m VARIA DE CERO A 4; 6) n VARIA DE 1 A 3; 7) p VARIA DE CERO A 2; EL CUAL ES UN IHHIBIDOR DE LA ENZIMA 17, 20 LIASA ESTERORIDAL POR LO QUE PUEDE DISMINURIR LOS NIVELES DE ANDROGENOS Y ESTROGENOS. PUEDE SER UTIL EN EL TRATAMIENTO DE TRANSTORNOS DE MAMA, ENDOMETRIO, OVARIO, PROSTATA, PANCREAS; TAL COMO CANCER DE PROSTATA
PE1994255110A 1993-05-21 1994-11-18 Derivado de carbazol sustituido, proceso para su preparacion y composicion farmaceutica que lo contiene PE31195A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939310635A GB9310635D0 (en) 1993-05-21 1993-05-21 Chemical compounds

Publications (1)

Publication Number Publication Date
PE31195A1 true PE31195A1 (es) 1995-10-18

Family

ID=10736007

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994255110A PE31195A1 (es) 1993-05-21 1994-11-18 Derivado de carbazol sustituido, proceso para su preparacion y composicion farmaceutica que lo contiene

Country Status (19)

Country Link
EP (1) EP0699196A1 (es)
JP (1) JPH08510455A (es)
CN (1) CN1126473A (es)
AU (1) AU6928794A (es)
BG (1) BG100154A (es)
CA (1) CA2162921A1 (es)
CZ (1) CZ305195A3 (es)
FI (1) FI955587A (es)
GB (1) GB9310635D0 (es)
HU (1) HUT73790A (es)
IL (1) IL109703A0 (es)
NO (1) NO954681D0 (es)
OA (1) OA10195A (es)
PE (1) PE31195A1 (es)
PL (1) PL311702A1 (es)
SK (1) SK142495A3 (es)
TW (1) TW279866B (es)
WO (1) WO1994027989A1 (es)
ZA (1) ZA943494B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT75871A (en) * 1993-09-30 1997-05-28 Yamanouchi Co Azole derivatives and pharmaceutical compositions thereof
AU3846395A (en) * 1994-11-07 1996-05-31 Janssen Pharmaceutica N.V. Compositions comprising carbazoles and cyclodextrins
CN1177350A (zh) * 1995-03-01 1998-03-25 山之内制药株式会社 咪唑衍生物及其药学组合物
CN1251577A (zh) * 1997-02-21 2000-04-26 武田药品工业株式会社 稠环化合物及其生产和应用
CN100572363C (zh) 2000-11-17 2009-12-23 武田药品工业株式会社 咪唑衍生物、其制备方法及其用途
ATE502030T1 (de) 2000-11-20 2011-04-15 Takeda Pharmaceutical Imidazolderivate, verfahren zu deren herstellung und deren verwendung
DE60139639D1 (de) 2000-12-08 2009-10-01 Takeda Pharmaceutical Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung
EP1902026B1 (en) 2005-06-24 2010-02-17 Eli Lilly And Company Tetrahydrocarbazole derivatives useful as androgen receptor modulators (sarm)
US8093279B2 (en) 2005-12-13 2012-01-10 Gillian Reed, legal representative Compound
GB0525323D0 (en) * 2005-12-13 2006-01-18 Sterix Ltd Compound
CN100586932C (zh) * 2007-01-26 2010-02-03 中国医学科学院医药生物技术研究所 抗肿瘤化合物及其制备方法
UA105794C2 (uk) 2009-06-26 2014-06-25 Новартіс Аг 1,3-ДИЗАМІЩЕНІ ПОХІДНІ ІМІДАЗОЛІДИН-2-ОНУ ЯК ІНГІБІТОРИ Cyp17
AU2011212813B2 (en) * 2010-02-04 2014-10-23 Radius Health, Inc. Selective androgen receptor modulators
ME02474B (me) 2010-05-12 2017-02-20 Radius Health Inc Terapijski režimi
US9132105B2 (en) 2010-08-04 2015-09-15 Pellficure Pharmaceuticals, Inc. Treatment of prostate carcinoma
US8946260B2 (en) 2010-09-16 2015-02-03 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
EP2621901B1 (en) 2010-09-28 2015-07-29 Radius Health, Inc Selective androgen receptor modulators
ES2656218T3 (es) 2011-04-28 2018-02-26 Novartis Ag Inhibidores de 17 alfa-hidroxilasa/C17,20-liasa
US9492460B2 (en) * 2013-02-27 2016-11-15 Bristol-Myers Squibb Company Carbazole compounds useful as bromodomain inhibitors
CA2902335C (en) 2013-03-14 2021-09-14 Pellficure Pharmaceuticals, Inc. Novel therapy for prostate carcinoma
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
DK3122426T3 (da) 2014-03-28 2023-04-03 Univ Duke Behandling af brystcancer ved anvendelse af selektive østrogenreceptormodulatorer
US10093620B2 (en) 2014-09-12 2018-10-09 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
LT3474841T (lt) 2016-06-22 2022-06-10 Ellipses Pharma Ltd Ar+ krūties vėžio gydymo būdai
EP3528799A1 (en) 2016-10-24 2019-08-28 Pellficure Pharmaceuticals, Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione
PL3565542T3 (pl) 2017-01-05 2024-07-29 Radius Pharmaceuticals, Inc. Postacie polimorficzne rad1901-2hcl

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
BG100154A (en) 1996-07-31
TW279866B (es) 1996-07-01
OA10195A (en) 1996-12-18
AU6928794A (en) 1994-12-20
PL311702A1 (en) 1996-03-04
CN1126473A (zh) 1996-07-10
ZA943494B (en) 1995-01-23
FI955587A0 (fi) 1995-11-20
NO954681L (no) 1995-11-20
GB9310635D0 (en) 1993-07-07
JPH08510455A (ja) 1996-11-05
EP0699196A1 (en) 1996-03-06
IL109703A0 (en) 1994-08-26
FI955587A (fi) 1995-11-20
WO1994027989A1 (en) 1994-12-08
HUT73790A (en) 1996-09-30
SK142495A3 (en) 1996-06-05
NO954681D0 (no) 1995-11-20
CZ305195A3 (en) 1996-06-12
CA2162921A1 (en) 1994-12-08
HU9503321D0 (en) 1996-01-29

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