SG11201909735YA - Therapeutic compounds and compositions, and methods of use thereof - Google Patents

Therapeutic compounds and compositions, and methods of use thereof

Info

Publication number
SG11201909735YA
SG11201909735YA SG11201909735YA SG11201909735YA SG 11201909735Y A SG11201909735Y A SG 11201909735YA SG 11201909735Y A SG11201909735Y A SG 11201909735YA SG 11201909735Y A SG11201909735Y A SG 11201909735YA
Authority
SG
Singapore
Prior art keywords
international
pct
methods
designated states
compositions
Prior art date
Application number
Inventor
Mark Zak
F Anthony Romero
Yun-Xing Cheng
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201909735YA publication Critical patent/SG11201909735YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 November 2018 (29.11.2018) WIPO I PCT mu °mons ono o VI IIIII onll oil Eno iflo oimIE (10) International Publication Number WO 2018/215389 Al (51) International Patent Classification: CO7D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: (22) International Filing Date: PCT/EP2018/063262 Published: — with international search report (Art. 21(3)) 21 May 2018 (21.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2017/085276 22 May 2017 (22.05.2017) CN 62/640,865 09 March 2018 (09.03.2018) US (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant (for US only): GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, California 94080 (US). (72) Inventors: ZAK, Mark; c/o Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080 (US). ROMERO, F. An- thony; 3280 Bayshore Boulevard, Brisbane, CA 94005 (US). CHENG, Yun-Xing; 6 Tai-he Road, BDA, Beijing 100176 (CN). (74) Agent: SCHIRLIN, Julien; Grenzacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 1-1 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 00 11 el (54) Title: THERAPEUTIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF USE THEREOF (57) : Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharma- O ceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of \" treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
SG11201909735Y 2017-05-22 2018-05-21 Therapeutic compounds and compositions, and methods of use thereof SG11201909735YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017085276 2017-05-22
US201862640865P 2018-03-09 2018-03-09
PCT/EP2018/063262 WO2018215389A1 (en) 2017-05-22 2018-05-21 Therapeutic compounds and compositions, and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201909735YA true SG11201909735YA (en) 2019-11-28

Family

ID=62386421

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201909735Y SG11201909735YA (en) 2017-05-22 2018-05-21 Therapeutic compounds and compositions, and methods of use thereof

Country Status (19)

Country Link
US (3) US10307426B2 (en)
EP (1) EP3630766A1 (en)
JP (2) JP7256757B2 (en)
KR (1) KR20200010390A (en)
CN (1) CN110650959B (en)
AU (1) AU2018274577A1 (en)
BR (1) BR112019024322A2 (en)
CA (1) CA3061236A1 (en)
CL (1) CL2019003258A1 (en)
CO (1) CO2019010559A2 (en)
CR (1) CR20190520A (en)
MA (1) MA48942A (en)
MX (1) MX2019013308A (en)
PE (1) PE20200341A1 (en)
PH (1) PH12019502601A1 (en)
RU (1) RU2769696C2 (en)
SG (1) SG11201909735YA (en)
TW (1) TW201902896A (en)
WO (1) WO2018215389A1 (en)

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TW202115068A (en) 2019-06-18 2021-04-16 瑞士商赫孚孟拉羅股份公司 Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof
JP2022537354A (en) * 2019-06-18 2022-08-25 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Pyrazolopyrimidine aryl ether inhibitors of JAK kinases and uses thereof
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

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TW201902896A (en) 2019-01-16
BR112019024322A2 (en) 2020-06-16
JP2020520959A (en) 2020-07-16
CN110650959B (en) 2023-04-18
PE20200341A1 (en) 2020-02-14
EP3630766A1 (en) 2020-04-08
RU2019141734A3 (en) 2021-08-10
CR20190520A (en) 2020-01-21
MX2019013308A (en) 2020-02-12
US10307426B2 (en) 2019-06-04
CA3061236A1 (en) 2018-11-29
CO2019010559A2 (en) 2019-10-09
PH12019502601A1 (en) 2020-06-08
KR20200010390A (en) 2020-01-30
MA48942A (en) 2020-04-08
US20190240227A1 (en) 2019-08-08
CL2019003258A1 (en) 2020-04-17
JP2023058657A (en) 2023-04-25
AU2018274577A1 (en) 2019-10-10
RU2769696C2 (en) 2022-04-05
CN110650959A (en) 2020-01-03
RU2019141734A (en) 2021-06-23
US20200352951A1 (en) 2020-11-12
WO2018215389A1 (en) 2018-11-29
JP7256757B2 (en) 2023-04-12
US20180333416A1 (en) 2018-11-22

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