MX2016016530A - Inhibidores de fosfatidilinositol 3-quinasa. - Google Patents

Inhibidores de fosfatidilinositol 3-quinasa.

Info

Publication number
MX2016016530A
MX2016016530A MX2016016530A MX2016016530A MX2016016530A MX 2016016530 A MX2016016530 A MX 2016016530A MX 2016016530 A MX2016016530 A MX 2016016530A MX 2016016530 A MX2016016530 A MX 2016016530A MX 2016016530 A MX2016016530 A MX 2016016530A
Authority
MX
Mexico
Prior art keywords
phosphatidylinositol
compounds
kinase inhibitors
tautomer
isomers
Prior art date
Application number
MX2016016530A
Other languages
English (en)
Inventor
Phillips Gary
Van Veldhuizen Joshua
W Phillips Barton
L Stevens Kirk
Kim Musong
Patel Leena
Du Zhimin
j watkins William
Naduthambi Devan
Chung Yeung Suet
Cai Shaopei
A Loyer-Drew Jennifer
Anne Treiberg Jennifer
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2016016530A publication Critical patent/MX2016016530A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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Abstract

La presente solicitud proporciona los compuestos de la fórmula (J) o sales, isómeros, tautómero farmacéuticamente aceptables o una mezcla de los mismos, en donde n, W, A', B', R1, R2 y R3 se describen en el presente documento. Los compuestos son inhibidores de los actividades de fosfatidilinositol 3-quinasa (PI3K) y son útiles para tratar las condiciones mediadas por una o más isoformas de PI3K. La presente solicitud además proporciona composiciones farmacéuticas que incluyen un compuesto de la fórmula (I) o sales, isómeros, tautómeros farmacéuticamente aceptables o mezclas de los mismos y métodos de uso de estos compuestos y composiciones para tratar las condiciones mediadas por una o más isoformas de P13K.
MX2016016530A 2014-06-13 2015-06-10 Inhibidores de fosfatidilinositol 3-quinasa. MX2016016530A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462012172P 2014-06-13 2014-06-13
PCT/US2015/035126 WO2015191726A1 (en) 2014-06-13 2015-06-10 Phosphatidylinositol 3-kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2016016530A true MX2016016530A (es) 2017-03-27

Family

ID=53674245

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016016530A MX2016016530A (es) 2014-06-13 2015-06-10 Inhibidores de fosfatidilinositol 3-quinasa.

Country Status (18)

Country Link
US (1) US11021467B2 (es)
EP (1) EP3154960A1 (es)
JP (1) JP6455995B2 (es)
KR (1) KR20170012560A (es)
CN (1) CN106459005A (es)
AR (1) AR100808A1 (es)
AU (1) AU2015274696B2 (es)
BR (1) BR112016028642A2 (es)
CA (1) CA2952012A1 (es)
EA (1) EA201692268A1 (es)
HK (1) HK1231476A1 (es)
IL (1) IL248897A0 (es)
MA (1) MA40059A (es)
MX (1) MX2016016530A (es)
NZ (1) NZ726360A (es)
SG (1) SG11201609877XA (es)
TW (1) TW201625560A (es)
WO (1) WO2015191726A1 (es)

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CA2952037A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
US9499523B2 (en) 2014-06-13 2016-11-22 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
CA2952025A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
JP6455995B2 (ja) 2014-06-13 2019-01-23 ギリアード サイエンシーズ， インコーポレイテッド ホスファチジルイノシトール３−キナーゼ阻害剤
CA2952018A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
CN106459008A (zh) * 2014-06-24 2017-02-22 吉利德科学公司 磷脂酰肌醇3‑激酶抑制剂
PE20170640A1 (es) 2014-07-04 2017-05-26 Lupin Ltd Derivados de quinolizinona como inhibidores de pi3k
SG10202105371YA (en) 2014-12-26 2021-07-29 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
FI3706762T3 (fi) 2017-12-07 2024-12-13 Univ Emory N4-hydroksisytidiini ja johdannaisia sekä niihin liittyviä virusten vastaisia käyttötapoja
CA3083040A1 (en) 2018-01-20 2019-07-25 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
CN110590681B (zh) * 2019-09-30 2021-06-01 中山大学 一种新型喹唑啉酮类化合物及其制备方法和应用
CN111440173B (zh) * 2020-03-27 2021-05-14 山东大学 一种pi3k抑制剂的制备方法

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