MX2016016538A - Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa. - Google Patents

Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa.

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Publication number
MX2016016538A
MX2016016538A MX2016016538A MX2016016538A MX2016016538A MX 2016016538 A MX2016016538 A MX 2016016538A MX 2016016538 A MX2016016538 A MX 2016016538A MX 2016016538 A MX2016016538 A MX 2016016538A MX 2016016538 A MX2016016538 A MX 2016016538A
Authority
MX
Mexico
Prior art keywords
phosphatidylinositol
compounds
kinase inhibitors
quinazolinone derivatives
tautomer
Prior art date
Application number
MX2016016538A
Other languages
English (en)
Inventor
Phillips Gary
W Phillips Barton
Evarts Jerry
Kaplan Joshua
Patel Leena
Perreault Stephane
A Treiberg Jennifer
Chung Yeung Suet
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2016016538A publication Critical patent/MX2016016538A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

La presente solicitud provee los compuestos de la fórmula (J), o sales farmacéuticamente aceptables, isómeros, tautómero, o una mezcla de los mismos, en la cual X, Y, Z, n, m', A', R1, R2 y R3 se describen en la presente solicitud. Los compuestos son inhibidores para las actividades de fosfatidilinositol 3-cinasa (PI3K) y son útiles para tratar condiciones mediadas por una o más isoformas de PI3K. La presente solicitud también provee composiciones farmacéuticas que incluyen un compuesto de la fórmula (1), o sales farmacéuticamente aceptables, isómeros, tautómero o mezcla de los mismos, y métodos para utilizar estos compuestos y composiciones para tratar condiciones mediadas por una o más isoformas de PI3K.
MX2016016538A 2014-06-13 2015-06-10 Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa. MX2016016538A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462011775P 2014-06-13 2014-06-13
PCT/US2015/035145 WO2015191743A1 (en) 2014-06-13 2015-06-10 Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2016016538A true MX2016016538A (es) 2017-05-01

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MX2016016538A MX2016016538A (es) 2014-06-13 2015-06-10 Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa.

Country Status (17)

Country Link
US (1) US10308639B2 (es)
EP (1) EP3154961B1 (es)
JP (1) JP6383810B2 (es)
KR (1) KR20170015508A (es)
CN (1) CN106459012A (es)
AR (1) AR100806A1 (es)
AU (1) AU2015274626C1 (es)
BR (1) BR112016028876A2 (es)
CA (1) CA2952018A1 (es)
EA (1) EA201692266A1 (es)
ES (1) ES2763104T3 (es)
IL (1) IL248789A0 (es)
MX (1) MX2016016538A (es)
NZ (1) NZ726055A (es)
SG (1) SG11201609527PA (es)
TW (1) TW201625590A (es)
WO (1) WO2015191743A1 (es)

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EA201692249A1 (ru) 2014-06-13 2017-05-31 Джилид Сайэнс, Инк. Ингибиторы фосфатидилинозитол-3-киназы
WO2015191754A2 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
EA201692267A1 (ru) 2014-06-13 2017-06-30 Джилид Сайэнс, Инк. Ингибиторы фосфатидилинозитол-3-киназы
AU2015274696B2 (en) 2014-06-13 2018-09-27 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
BR112016028876A2 (pt) 2014-06-13 2017-08-22 Gilead Sciences Inc composto, composição farmacêutica, método para tratar uma doença ou condição em um ser humano, kit, e, uso de um composto, um sal, isômero ou uma mistura farmaceuticamente aceitável dos mesmos.
HRP20211456T1 (hr) 2014-12-26 2021-12-24 Emory University Protuvirusni derivati n4-hidroksicitidina
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
KR101932146B1 (ko) 2016-07-14 2018-12-24 주식회사 바이오웨이 Pi3k를 억제하는 신규한 퀴나졸리논 유도체 및 이를 포함하는 약학적 조성물
KR102248165B1 (ko) 2017-12-07 2021-05-06 에모리 유니버시티 N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도
WO2019143874A1 (en) 2018-01-20 2019-07-25 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
CN108546268B (zh) * 2018-05-28 2019-04-09 西安培华学院 用于治疗动脉粥样硬化的化合物及其应用
CN110013483B (zh) * 2019-05-10 2022-04-15 江苏师范大学 噻唑并[3,2-a]嘧啶-6-甲腈衍生物用于抗菌的用途
CN113512042B (zh) * 2020-04-09 2024-06-11 成都赜灵生物医药科技有限公司 取代喹唑啉-4-酮类化合物及其制备方法和用途
CN117222413A (zh) * 2021-02-10 2023-12-12 同润生物医药(上海)有限公司 治疗肿瘤的方法和组合

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