BR112017000826A2 - novas 2,5-piridinas substituídas. - Google Patents

novas 2,5-piridinas substituídas.

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Publication number
BR112017000826A2
BR112017000826A2 BR112017000826A BR112017000826A BR112017000826A2 BR 112017000826 A2 BR112017000826 A2 BR 112017000826A2 BR 112017000826 A BR112017000826 A BR 112017000826A BR 112017000826 A BR112017000826 A BR 112017000826A BR 112017000826 A2 BR112017000826 A2 BR 112017000826A2
Authority
BR
Brazil
Prior art keywords
pyridines
new substituted
medicaments
substituted
new
Prior art date
Application number
BR112017000826A
Other languages
English (en)
Inventor
Welbers Andre
Nardi Antonio
Hesslinger Christian
Jakob Florian
Konetzki Ingo
Craan Tobias
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BR112017000826A2 publication Critical patent/BR112017000826A2/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

novas 2,5-piridinas substituídas. a invenção está relacionada a novos compostos de pirimidina condensados substituídos de fórmula geral (i) na qual os agrupamentos químicos, substituintes e índices são como definido na descrição, e a seu uso como medicamentos, em particular como medicamentos para o tratamento de condições e doenças que podem ser tratadas pela inibição da enzima pde4.
BR112017000826A 2014-07-16 2015-07-16 novas 2,5-piridinas substituídas. BR112017000826A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14002451 2014-07-16
PCT/EP2015/001475 WO2016008592A1 (en) 2014-07-16 2015-07-16 Novel 2,5-substituted pyrimidines as pde inhibitors

Publications (1)

Publication Number Publication Date
BR112017000826A2 true BR112017000826A2 (pt) 2017-12-05

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Application Number Title Priority Date Filing Date
BR112017000826A BR112017000826A2 (pt) 2014-07-16 2015-07-16 novas 2,5-piridinas substituídas.

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US (1) US9315490B2 (pt)
EP (2) EP3169680A1 (pt)
JP (1) JP6726655B2 (pt)
KR (1) KR20170032420A (pt)
CN (1) CN106488916A (pt)
AR (1) AR101197A1 (pt)
AU (1) AU2015291477B2 (pt)
BR (1) BR112017000826A2 (pt)
CA (1) CA2955062A1 (pt)
CL (1) CL2017000105A1 (pt)
CO (1) CO2017001523A2 (pt)
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AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
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US20160024053A1 (en) 2016-01-28
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