BR112017000821A2 - novos compostos de pirimidina substituída. - Google Patents

novos compostos de pirimidina substituída.

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Publication number
BR112017000821A2
BR112017000821A2 BR112017000821A BR112017000821A BR112017000821A2 BR 112017000821 A2 BR112017000821 A2 BR 112017000821A2 BR 112017000821 A BR112017000821 A BR 112017000821A BR 112017000821 A BR112017000821 A BR 112017000821A BR 112017000821 A2 BR112017000821 A2 BR 112017000821A2
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BR
Brazil
Prior art keywords
pyrimidine compounds
substituted pyrimidine
new substituted
medicaments
new
Prior art date
Application number
BR112017000821A
Other languages
English (en)
Inventor
Nardi Antonio
Hesslinger Christian
Jakob Florian
Konetzki Ingo
DOODEMAN Robin
Craan Tobias
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BR112017000821A2 publication Critical patent/BR112017000821A2/pt

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

novos compostos de pirimidina substituída. a invenção está relacionada a novos compostos de pirimidina substituída de fórmula geral (i) (i) na qual os agrupamentos químicos, substituintes, variáveis e índices são como definidos na descrição, e a seu uso como medicamentos, em particular como medicamentos para o tratamento de condições e doenças que podem ser tratadas pela inibição da enzima pde4.
BR112017000821A 2014-07-16 2015-07-16 novos compostos de pirimidina substituída. BR112017000821A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14002452 2014-07-16
PCT/EP2015/001476 WO2016008593A1 (en) 2014-07-16 2015-07-16 Novel substituted pyrimidine compounds

Publications (1)

Publication Number Publication Date
BR112017000821A2 true BR112017000821A2 (pt) 2017-12-05

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BR112017000821A BR112017000821A2 (pt) 2014-07-16 2015-07-16 novos compostos de pirimidina substituída.

Country Status (18)

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US (2) US9540349B2 (pt)
EP (2) EP3527561A1 (pt)
JP (1) JP6738795B2 (pt)
KR (1) KR20170029614A (pt)
CN (1) CN107074812B (pt)
AR (1) AR101196A1 (pt)
AU (1) AU2015291478B2 (pt)
BR (1) BR112017000821A2 (pt)
CA (1) CA2955070A1 (pt)
CL (1) CL2017000104A1 (pt)
CO (1) CO2017001528A2 (pt)
EA (1) EA201790207A8 (pt)
EC (1) ECSP17010238A (pt)
IL (1) IL250022B (pt)
MX (1) MX2017000524A (pt)
PE (1) PE20170120A1 (pt)
TW (1) TW201609707A (pt)
WO (1) WO2016008593A1 (pt)

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AR101198A1 (es) * 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
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WO2018234353A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE
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IL250022A0 (en) 2017-03-30
CL2017000104A1 (es) 2017-08-04
MX2017000524A (es) 2017-05-01
US20160016937A1 (en) 2016-01-21
AR101196A1 (es) 2016-11-30
PE20170120A1 (es) 2017-03-30
AU2015291478B2 (en) 2019-04-04
KR20170029614A (ko) 2017-03-15
TW201609707A (zh) 2016-03-16
EA201790207A1 (ru) 2017-07-31
EP3169681A1 (en) 2017-05-24
CN107074812A (zh) 2017-08-18
US10189854B2 (en) 2019-01-29
US9540349B2 (en) 2017-01-10
ECSP17010238A (es) 2017-03-31
CO2017001528A2 (es) 2017-05-10
WO2016008593A1 (en) 2016-01-21
JP2017520602A (ja) 2017-07-27
US20170066776A1 (en) 2017-03-09
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EA201790207A8 (ru) 2018-06-29
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