BR112016023558A2 - compostos úteis como imunomoduladores - Google Patents

compostos úteis como imunomoduladores

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Publication number
BR112016023558A2
BR112016023558A2 BR112016023558A BR112016023558A BR112016023558A2 BR 112016023558 A2 BR112016023558 A2 BR 112016023558A2 BR 112016023558 A BR112016023558 A BR 112016023558A BR 112016023558 A BR112016023558 A BR 112016023558A BR 112016023558 A2 BR112016023558 A2 BR 112016023558A2
Authority
BR
Brazil
Prior art keywords
immunomodulators
compounds
compounds useful
useful
disclosure
Prior art date
Application number
BR112016023558A
Other languages
English (en)
Inventor
J Tenney Daniel
R Langley David
Zhu Juliang
Yeung Kap-Sun
S Chupak Louis
Ding Min
Xu Ningning
Michael Scola Paul
Hewawasam Piyasena
w martin Scott
p connolly Timothy
Zheng Xiaofan
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR112016023558A2 publication Critical patent/BR112016023558A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

a presente revelação de um modo geral refere-se a compostos úteis como imunomoduladores. são fornecidos aqui compostos, composições compreendendo tais compostos, e métodos de seu uso. a revelação também diz respeito a composições farmacêuticas compreendendo pelo menos um composto de acordo com a revelação, que é útil para o tratamento de várias doenças, incluindo câncer e doenças infecciosas.
BR112016023558A 2014-04-14 2015-04-10 compostos úteis como imunomoduladores BR112016023558A2 (pt)

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US14/681,772 US9850225B2 (en) 2014-04-14 2015-04-08 Compounds useful as immunomodulators
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