AR120109A1 - Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores - Google Patents

Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores

Info

Publication number
AR120109A1
AR120109A1 ARP200102697A ARP200102697A AR120109A1 AR 120109 A1 AR120109 A1 AR 120109A1 AR P200102697 A ARP200102697 A AR P200102697A AR P200102697 A ARP200102697 A AR P200102697A AR 120109 A1 AR120109 A1 AR 120109A1
Authority
AR
Argentina
Prior art keywords
immunomodulators
pyrido
pyrimidine compounds
compound
formula
Prior art date
Application number
ARP200102697A
Other languages
English (en)
Inventor
Jingwei Li
Liangxing Wu
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of AR120109A1 publication Critical patent/AR120109A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente descripción hace referencia a compuestos de fórmula (1) que modulan la interacción proteína / proteína de PD-1 / PD-L1, composiciones y métodos para tratar diversas enfermedades, que incluyen enfermedades infecciosas y cáncer. Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable de este, caracterizado porque: R¹ es CH₃ o Cl; R² es un compuesto del grupo de fórmulas (2); R³ es H o CH₃; R⁴ es H o CH₃; y R⁵ es H o CH₃.
ARP200102697A 2019-09-30 2020-09-29 Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores AR120109A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962908317P 2019-09-30 2019-09-30

Publications (1)

Publication Number Publication Date
AR120109A1 true AR120109A1 (es) 2022-02-02

Family

ID=72886166

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200102697A AR120109A1 (es) 2019-09-30 2020-09-29 Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores

Country Status (18)

Country Link
US (2) US11401279B2 (es)
EP (1) EP4037773A1 (es)
JP (1) JP2022549375A (es)
KR (1) KR20220075382A (es)
CN (1) CN115175734B (es)
AR (1) AR120109A1 (es)
AU (1) AU2020357514A1 (es)
BR (1) BR112022005826A2 (es)
CA (1) CA3155852A1 (es)
CL (1) CL2022000787A1 (es)
CO (1) CO2022005378A2 (es)
CR (1) CR20220190A (es)
EC (1) ECSP22034236A (es)
IL (1) IL291471A (es)
MX (1) MX2022003578A (es)
PE (1) PE20221038A1 (es)
TW (1) TW202126652A (es)
WO (1) WO2021067217A1 (es)

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WO2021254005A1 (zh) * 2020-06-17 2021-12-23 上海和誉生物医药科技有限公司 一种免疫抑制剂、其制备方法和应用
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