PE20221038A1 - Compuestos de pirido[3,2-d] pirimidina como inmunomoduladores - Google Patents

Compuestos de pirido[3,2-d] pirimidina como inmunomoduladores

Info

Publication number
PE20221038A1
PE20221038A1 PE2022000462A PE2022000462A PE20221038A1 PE 20221038 A1 PE20221038 A1 PE 20221038A1 PE 2022000462 A PE2022000462 A PE 2022000462A PE 2022000462 A PE2022000462 A PE 2022000462A PE 20221038 A1 PE20221038 A1 PE 20221038A1
Authority
PE
Peru
Prior art keywords
methyl
pyrido
immunomodulators
compounds
methylpyrrolidin
Prior art date
Application number
PE2022000462A
Other languages
English (en)
Inventor
Jingwei Li
Liangxing Wu
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PE20221038A1 publication Critical patent/PE20221038A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta referido a compuestos derivados de pirido[3,2-d]pirimidina de Formula I, en donde: R1 es CH3, Cl; y, R2 es una de las formulas que se indican a continuacion. Entre los compuestos preferidos tenemos los siguientes: acido (R)-4-(2-(2-((2-cloro-3'-((2-(difluorometil)-7-((3- hidroxi-3-metilpirrolidin-1-il)metil)pirido[3,2-d]pirimidin-4-il)amino)-2'- metil-[1,1'-bifenil]-3-il)carbamoil)-1-metil-1,4,6,7-tetrahidro-5H-imidazo[4,5-c]piridin-5- il)etil)biciclo[2.2.1]heptano-1-carboxilico; acido (S)-4-(2-(2-((2-cloro-3'-((2-(difluorometil)-7-((3-hidroxi-3-metilpirrolidin-1-il)metil)pirido[3,2-d]pirimidin-4-il)amino)-2'- metil-[1,1'-bifenil]-3-il)carbamoil)-1-metil-1,4,6,7-tetrahidro-5H-imidazo[4,5-c]piridin-5- il)etil)biciclo[2.2.1]heptano-1-carboxilico; entre otros. Estos compuestos modulan la interaccion proteina/proteina de PD-1/PD-L1 y son utiles en el tratamiento de diversas enfermedades que incluyen enfermedades infecciosas y cancer.
PE2022000462A 2019-09-30 2020-09-29 Compuestos de pirido[3,2-d] pirimidina como inmunomoduladores PE20221038A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962908317P 2019-09-30 2019-09-30
PCT/US2020/053190 WO2021067217A1 (en) 2019-09-30 2020-09-29 Pyrido[3,2-d]pyrimidine compounds as immunomodulators

Publications (1)

Publication Number Publication Date
PE20221038A1 true PE20221038A1 (es) 2022-06-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022000462A PE20221038A1 (es) 2019-09-30 2020-09-29 Compuestos de pirido[3,2-d] pirimidina como inmunomoduladores

Country Status (18)

Country Link
US (2) US11401279B2 (es)
EP (1) EP4037773A1 (es)
JP (1) JP2022549375A (es)
KR (1) KR20220075382A (es)
CN (1) CN115175734B (es)
AR (1) AR120109A1 (es)
AU (1) AU2020357514A1 (es)
BR (1) BR112022005826A2 (es)
CA (1) CA3155852A1 (es)
CL (1) CL2022000787A1 (es)
CO (1) CO2022005378A2 (es)
CR (1) CR20220190A (es)
EC (1) ECSP22034236A (es)
IL (1) IL291471A (es)
MX (1) MX2022003578A (es)
PE (1) PE20221038A1 (es)
TW (1) TW202126652A (es)
WO (1) WO2021067217A1 (es)

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