CR20220190A - Compuestos de pirido [3,2-d] primidina como inmunomoduladores - Google Patents

Compuestos de pirido [3,2-d] primidina como inmunomoduladores

Info

Publication number
CR20220190A
CR20220190A CR20220190A CR20220190A CR20220190A CR 20220190 A CR20220190 A CR 20220190A CR 20220190 A CR20220190 A CR 20220190A CR 20220190 A CR20220190 A CR 20220190A CR 20220190 A CR20220190 A CR 20220190A
Authority
CR
Costa Rica
Prior art keywords
immunomodulators
pyrido
pyrimidine compounds
compounds
protein
Prior art date
Application number
CR20220190A
Other languages
English (en)
Inventor
Liangxing Wu
Jingwei Li
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CR20220190A publication Critical patent/CR20220190A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente descripción hace referencia a compuestos de Fórmula (I): que modulan la interacción proteína/proteína de PD-1/PD-L1, composiciones y métodos para tratar diversas enfermedades, que incluyen enfermedades infecciosas y cáncer.
CR20220190A 2019-09-30 2020-09-29 Compuestos de pirido [3,2-d] primidina como inmunomoduladores CR20220190A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962908317P 2019-09-30 2019-09-30
PCT/US2020/053190 WO2021067217A1 (en) 2019-09-30 2020-09-29 Pyrido[3,2-d]pyrimidine compounds as immunomodulators

Publications (1)

Publication Number Publication Date
CR20220190A true CR20220190A (es) 2022-06-15

Family

ID=72886166

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220190A CR20220190A (es) 2019-09-30 2020-09-29 Compuestos de pirido [3,2-d] primidina como inmunomoduladores

Country Status (18)

Country Link
US (2) US11401279B2 (es)
EP (1) EP4037773A1 (es)
JP (1) JP7559059B2 (es)
KR (1) KR20220075382A (es)
CN (1) CN115175734B (es)
AR (1) AR120109A1 (es)
AU (1) AU2020357514A1 (es)
BR (1) BR112022005826A2 (es)
CA (1) CA3155852A1 (es)
CL (1) CL2022000787A1 (es)
CO (1) CO2022005378A2 (es)
CR (1) CR20220190A (es)
EC (1) ECSP22034236A (es)
IL (1) IL291471A (es)
MX (1) MX2022003578A (es)
PE (1) PE20221038A1 (es)
TW (1) TW202126652A (es)
WO (1) WO2021067217A1 (es)

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WO2018119266A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Benzooxazole derivatives as immunomodulators
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US11168089B2 (en) 2018-05-18 2021-11-09 Incyte Corporation Fused pyrimidine derivatives as A2A / A2B inhibitors
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TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
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JP7559059B2 (ja) * 2019-09-30 2024-10-01 インサイト・コーポレイション 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物
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WO2021254005A1 (zh) * 2020-06-17 2021-12-23 上海和誉生物医药科技有限公司 一种免疫抑制剂、其制备方法和应用
TW202233615A (zh) 2020-11-06 2022-09-01 美商英塞特公司 Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式
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