MX2022000573A - Compuestos ciclicos de desoxirribonucleotido. - Google Patents

Compuestos ciclicos de desoxirribonucleotido.

Info

Publication number
MX2022000573A
MX2022000573A MX2022000573A MX2022000573A MX2022000573A MX 2022000573 A MX2022000573 A MX 2022000573A MX 2022000573 A MX2022000573 A MX 2022000573A MX 2022000573 A MX2022000573 A MX 2022000573A MX 2022000573 A MX2022000573 A MX 2022000573A
Authority
MX
Mexico
Prior art keywords
deoxyribonucleotide
compounds
cyclic
cancer
preparation
Prior art date
Application number
MX2022000573A
Other languages
English (en)
Inventor
Lin Zhi
Original Assignee
Nucorion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nucorion Pharmaceuticals Inc filed Critical Nucorion Pharmaceuticals Inc
Publication of MX2022000573A publication Critical patent/MX2022000573A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

En la presente se proporcionan compuestos cíclicos de desoxirribonucleótido derivado de 5-fluorouracilo su preparación y sus usos como tratamiento de enfermedades del hígado o varios tipos de cáncer.
MX2022000573A 2019-07-17 2020-07-15 Compuestos ciclicos de desoxirribonucleotido. MX2022000573A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962875190P 2019-07-17 2019-07-17
PCT/US2020/042187 WO2021011692A1 (en) 2019-07-17 2020-07-15 Cyclic deoxyribonucleotide compounds

Publications (1)

Publication Number Publication Date
MX2022000573A true MX2022000573A (es) 2022-02-10

Family

ID=74209964

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022000573A MX2022000573A (es) 2019-07-17 2020-07-15 Compuestos ciclicos de desoxirribonucleotido.

Country Status (10)

Country Link
US (1) US20220298199A1 (es)
EP (1) EP3999519A4 (es)
JP (1) JP2022541877A (es)
KR (1) KR20220035143A (es)
CN (1) CN114206896A (es)
AU (1) AU2020315394A1 (es)
CA (1) CA3143349A1 (es)
MX (1) MX2022000573A (es)
TW (1) TW202116329A (es)
WO (1) WO2021011692A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3541825A1 (en) * 2016-11-21 2019-09-25 Idenix Pharmaceuticals LLC. Cyclic phosphate substituted nucleoside derivatives for the treatment of liver diseases
CN111801339A (zh) * 2018-01-19 2020-10-20 纽科利制药公司 5-氟尿嘧啶化合物
CA3138978A1 (en) * 2019-05-03 2020-11-12 Terns Pharmaceuticals, Inc. Compounds for treating cancer
WO2022245584A1 (en) * 2021-05-17 2022-11-24 Ligand Pharmaceuticals Incorporated Unnatural configuration nucleotide prodrug compounds

Also Published As

Publication number Publication date
TW202116329A (zh) 2021-05-01
CA3143349A1 (en) 2021-01-21
WO2021011692A1 (en) 2021-01-21
EP3999519A4 (en) 2023-08-16
EP3999519A1 (en) 2022-05-25
JP2022541877A (ja) 2022-09-28
US20220298199A1 (en) 2022-09-22
KR20220035143A (ko) 2022-03-21
CN114206896A (zh) 2022-03-18
AU2020315394A1 (en) 2022-02-17

Similar Documents

Publication Publication Date Title
MX2021009246A (es) Inmunomoduladores, composiciones y metodos de los mismos.
AU2017319323A8 (en) Biaryl compounds useful as immunomodulators
PH12019501443A1 (en) Benzooxazole derivatives as immunomodulators
PH12018502710A1 (en) Heterocyclic compounds as immunomodulators
PH12021500014A1 (en) Fused ring compounds
PH12018501340A1 (en) Heterocyclic compounds as immunomodulators
PH12018501084A1 (en) Heterocyclic compounds as immunomodulators
PH12018501268A1 (en) Compounds useful as kinase inhibitors
MX2018004347A (es) Compuestos utiles como inmunomoduladores.
EA201891200A1 (ru) Композиции, содержащие бактериальные штаммы
PH12020550901A1 (en) Macrocyclic compounds for treating disease
EA201892229A1 (ru) Замещенные аминопуриновые соединения, содержащие их композиции и способы лечения с их применением
MX2020013853A (es) Compuestos innovadores.
MY198613A (en) Nitrobenzyl derivatives of anti-cancer agents
WO2018067512A8 (en) SPIROCYCLIC COMPOUNDS
MX2023014093A (es) Compuestos que interactuan con glicano y metodos de uso.
PH12020551043A1 (en) Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues
MX2018003351A (es) Derivados de pirazolopirimidina como inhibidores de la btk para el tratramiento de cancer.
MX2018009325A (es) Compuestos y metodos para tratar enfermedades mediadas por el acido ribonucleico (arn).
MX2017011655A (es) Compuestos de aza-piridona y usos de estos.
MY200161A (en) Bacteria for targeting tumors and treating cancer
MX2020007393A (es) Compuestos de fósforo(n)amidatacetal y fosf(on)atalcetal.
WO2019036417A3 (en) Inhibition of ngly1 for the treatment of cancer
PH12020551331A1 (en) Treatment and prevention of pre-eclampsia
MX2020012990A (es) Formulaciones de tegavivint y compuestos relacionados.