MX2022001181A - Inhibidores de kif18a. - Google Patents

Inhibidores de kif18a.

Info

Publication number
MX2022001181A
MX2022001181A MX2022001181A MX2022001181A MX2022001181A MX 2022001181 A MX2022001181 A MX 2022001181A MX 2022001181 A MX2022001181 A MX 2022001181A MX 2022001181 A MX2022001181 A MX 2022001181A MX 2022001181 A MX2022001181 A MX 2022001181A
Authority
MX
Mexico
Prior art keywords
kif18a
compounds
cancer
inhibitors
kif18a inhibitors
Prior art date
Application number
MX2022001181A
Other languages
English (en)
Inventor
Nuria A Tamayo
Matthew Paul Bourbeau
Abhisek Banerjee
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2022001181A publication Critical patent/MX2022001181A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmula (I): (ver Fórmula) (I), como se definen en el presente documento, y compuestos intermedios sintéticos de los mismos, que son capaces de modular la proteína KIF18A, alterando de esta forma el proceso del ciclo celular y la proliferación celular para tratar el cáncer y enfermedades relacionadas con el cáncer. La invención también incluye composiciones farmacéuticas que incluyen los compuestos, y métodos para tratar estados patológicos relacionados con la actividad de KIF18A.
MX2022001181A 2019-08-02 2020-08-03 Inhibidores de kif18a. MX2022001181A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962882271P 2019-08-02 2019-08-02
PCT/US2020/044800 WO2021026101A1 (en) 2019-08-02 2020-08-03 Kif18a inhibitors

Publications (1)

Publication Number Publication Date
MX2022001181A true MX2022001181A (es) 2022-02-22

Family

ID=72047174

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022001181A MX2022001181A (es) 2019-08-02 2020-08-03 Inhibidores de kif18a.

Country Status (8)

Country Link
US (1) US20220281843A1 (es)
EP (1) EP4007756A1 (es)
JP (1) JP2022542394A (es)
CN (1) CN114269731A (es)
AU (1) AU2020324963A1 (es)
CA (1) CA3147451A1 (es)
MX (1) MX2022001181A (es)
WO (1) WO2021026101A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021211549A1 (en) * 2020-04-14 2021-10-21 Amgen Inc. Kif18a inhibitors for treatment of neoplastic diseases
TW202237119A (zh) 2020-12-10 2022-10-01 美商住友製藥腫瘤公司 Ａｌｋ﹘５抑制劑和彼之用途
JP2024519482A (ja) * 2021-04-30 2024-05-14 チェンドゥ アンタイキャンサー バイオサイエンス リミテッド 抗がん活性を有するフェニル－ｏ－キノリン、キナゾリン、チエノピリジン、チエノピリミジン、ピロロピリジン、ピロロピリミジン化合物
AU2022298761A1 (en) 2021-06-25 2024-02-15 Hangzhou Innogate Pharma Co., Ltd. Compound as kif18a inhibitor
CA3230123A1 (en) * 2021-08-26 2023-03-02 Derek A. Cogan Spiro indoline inhibitors of kif18a
CN116903605A (zh) * 2022-04-15 2023-10-20 武汉人福创新药物研发中心有限公司 一种kif18a抑制剂及其用途
CN116804005B (zh) * 2022-05-13 2024-07-19 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
TW202400582A (zh) * 2022-05-13 2024-01-01 大陸商上海湃隆生物科技有限公司 驅動蛋白kif18a抑制劑及其應用
TW202408506A (zh) * 2022-06-30 2024-03-01 大陸商勤浩醫藥(蘇州)有限公司 一種含氮化合物及其應用
WO2024051812A1 (zh) * 2022-09-09 2024-03-14 先声再明医药有限公司 酰胺类化合物、其组合物及用途
WO2024067675A1 (zh) * 2022-09-30 2024-04-04 长春金赛药业有限责任公司 稠环类kif18a抑制剂化合物、药物组合物及其制备方法和应用
WO2024078513A1 (en) * 2022-10-10 2024-04-18 Chengdu Anticancer Bioscience , Ltd. Condensed azines for treating cancer
WO2024083137A1 (zh) * 2022-10-19 2024-04-25 海南先声再明医药股份有限公司 稠合杂芳烃类化合物、其组合物及用途
CN115594664B (zh) * 2022-11-25 2023-02-24 英矽智能科技(上海)有限公司 一类螺环衍生物作为kif18a抑制剂
WO2024125488A1 (zh) * 2022-12-14 2024-06-20 浙江海正药业股份有限公司 芳香酰胺类衍生物、其制备方法和其在医药上的应用
WO2024140799A1 (en) * 2022-12-28 2024-07-04 Insilico Medicine Ip Limited Inhibitors of kif18a and uses thereof

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