MX2010010151A - Moduladores de cinasa aurora y metodo de uso. - Google Patents

Moduladores de cinasa aurora y metodo de uso.

Info

Publication number
MX2010010151A
MX2010010151A MX2010010151A MX2010010151A MX2010010151A MX 2010010151 A MX2010010151 A MX 2010010151A MX 2010010151 A MX2010010151 A MX 2010010151A MX 2010010151 A MX2010010151 A MX 2010010151A MX 2010010151 A MX2010010151 A MX 2010010151A
Authority
MX
Mexico
Prior art keywords
aurora kinase
compounds
activity
disease states
influencing
Prior art date
Application number
MX2010010151A
Other languages
English (en)
Inventor
Ryan White
Jason B Human
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2010010151A publication Critical patent/MX2010010151A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos químicos que tienen una fórmula general (I) en donde A1-5 y 7-8, D´, L'1 L2, R1, R3, R6-8, n y o se definen en la presente, e intermediarios sintéticos, que son capaces de modular la actividad de proteínas de cinasa Aurora y, de tal manera, influenciar diversos estados de enfermedad y afecciones relacionadas con las actividades de cinasas Aurora. Por ejemplo, los compuestos son capaces de influenciar el proceso de ciclo celular y proliferación celular para tratar cáncer y enfermedades relacionadas con el cáncer. La invención también incluye composiciones farmacéuticas, incluyendo los compuestos, y métodos para tratar estados de enfermedad relacionados con la actividad de cinasa Aurora.
MX2010010151A 2008-03-20 2009-03-19 Moduladores de cinasa aurora y metodo de uso. MX2010010151A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7033308P 2008-03-20 2008-03-20
PCT/US2009/001785 WO2009117157A1 (en) 2008-03-20 2009-03-19 Aurora kinase modulators and method of use

Publications (1)

Publication Number Publication Date
MX2010010151A true MX2010010151A (es) 2010-10-25

Family

ID=40790547

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010010151A MX2010010151A (es) 2008-03-20 2009-03-19 Moduladores de cinasa aurora y metodo de uso.

Country Status (8)

Country Link
US (2) US8404694B2 (es)
EP (1) EP2288611B1 (es)
JP (1) JP2011515401A (es)
AU (1) AU2009226024B2 (es)
CA (1) CA2716856C (es)
ES (1) ES2413806T3 (es)
MX (1) MX2010010151A (es)
WO (1) WO2009117157A1 (es)

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Also Published As

Publication number Publication date
CA2716856C (en) 2013-02-19
EP2288611B1 (en) 2013-05-15
US20110065709A1 (en) 2011-03-17
WO2009117157A1 (en) 2009-09-24
JP2011515401A (ja) 2011-05-19
US8404694B2 (en) 2013-03-26
AU2009226024A1 (en) 2009-09-24
EP2288611A1 (en) 2011-03-02
ES2413806T3 (es) 2013-07-17
US20130165445A1 (en) 2013-06-27
AU2009226024B2 (en) 2012-07-12
CA2716856A1 (en) 2009-09-24

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