UA100545C2 - Гидроксилированные пиримидил циклопентаны как ингибиторы протеинкиназы акт - Google Patents
Гидроксилированные пиримидил циклопентаны как ингибиторы протеинкиназы актInfo
- Publication number
- UA100545C2 UA100545C2 UAA201009871A UAA201009871A UA100545C2 UA 100545 C2 UA100545 C2 UA 100545C2 UA A201009871 A UAA201009871 A UA A201009871A UA A201009871 A UAA201009871 A UA A201009871A UA 100545 C2 UA100545 C2 UA 100545C2
- Authority
- UA
- Ukraine
- Prior art keywords
- protein kinase
- kinase inhibitors
- akt protein
- hydroxylated
- pyrimidyl cyclopentanes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Данное изобретение описывает соединения, в том числе их фармацевтически приемлемые соли, которые соответствуют Формуле I: I, а также применение соединений согласно изобретению как ингибиторов протеинкиназы АКТ, а также для лечения гиперпролиферативных заболеваний, таких как рак.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2009208P | 2008-01-09 | 2008-01-09 | |
PCT/US2009/030610 WO2009089459A1 (en) | 2008-01-09 | 2009-01-09 | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
UA100545C2 true UA100545C2 (ru) | 2013-01-10 |
Family
ID=40552865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201009871A UA100545C2 (ru) | 2008-01-09 | 2009-09-01 | Гидроксилированные пиримидил циклопентаны как ингибиторы протеинкиназы акт |
Country Status (18)
Country | Link |
---|---|
US (1) | US8835434B2 (ru) |
EP (1) | EP2247578B1 (ru) |
JP (1) | JP5346345B2 (ru) |
KR (1) | KR101624753B1 (ru) |
CN (1) | CN101932564B (ru) |
AU (1) | AU2009204025B2 (ru) |
BR (1) | BRPI0906798A2 (ru) |
CA (1) | CA2711699A1 (ru) |
CR (1) | CR11601A (ru) |
EC (1) | ECSP10010389A (ru) |
ES (1) | ES2422733T3 (ru) |
IL (1) | IL206575A0 (ru) |
MA (1) | MA32183B1 (ru) |
NZ (1) | NZ586346A (ru) |
RU (1) | RU2504542C2 (ru) |
UA (1) | UA100545C2 (ru) |
WO (1) | WO2009089459A1 (ru) |
ZA (1) | ZA201004769B (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101801955B (zh) * | 2007-07-05 | 2013-05-08 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
JP5608097B2 (ja) | 2008-01-08 | 2014-10-15 | アレイ バイオファーマ、インコーポレイテッド | キナーゼ阻害薬としてのピロロピリジン |
CN101970415A (zh) | 2008-01-09 | 2011-02-09 | 阵列生物制药公司 | 作为AKT蛋白激酶抑制剂的5H-环戊二烯并[d]嘧啶 |
CN101965347B (zh) | 2008-01-09 | 2013-01-02 | 阵列生物制药公司 | 作为激酶抑制剂的吡唑并吡啶 |
PL2861583T3 (pl) * | 2012-05-17 | 2016-12-30 | Sposób wytwarzania hydroksylowanych związków cyklopentylopirymidyny | |
MX353041B (es) * | 2012-05-17 | 2017-12-18 | Genentech Inc | Formas y formulaciones de un compuesto de pirimidinilciclopentano, composiciones y métodos de este. |
MX2020009462A (es) | 2013-11-15 | 2021-08-31 | Hoffmann La Roche | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
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CN101801955B (zh) | 2007-07-05 | 2013-05-08 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
-
2009
- 2009-01-09 CA CA2711699A patent/CA2711699A1/en not_active Withdrawn
- 2009-01-09 ES ES09700422T patent/ES2422733T3/es active Active
- 2009-01-09 AU AU2009204025A patent/AU2009204025B2/en not_active Ceased
- 2009-01-09 EP EP09700422.0A patent/EP2247578B1/en active Active
- 2009-01-09 WO PCT/US2009/030610 patent/WO2009089459A1/en active Application Filing
- 2009-01-09 CN CN2009801019017A patent/CN101932564B/zh active Active
- 2009-01-09 US US12/811,957 patent/US8835434B2/en active Active
- 2009-01-09 NZ NZ586346A patent/NZ586346A/en not_active IP Right Cessation
- 2009-01-09 BR BRPI0906798-1A patent/BRPI0906798A2/pt not_active Application Discontinuation
- 2009-01-09 RU RU2010132911/04A patent/RU2504542C2/ru active
- 2009-01-09 KR KR1020107017605A patent/KR101624753B1/ko active IP Right Grant
- 2009-01-09 JP JP2010542376A patent/JP5346345B2/ja active Active
- 2009-09-01 UA UAA201009871A patent/UA100545C2/ru unknown
-
2010
- 2010-06-23 IL IL206575A patent/IL206575A0/en unknown
- 2010-07-06 ZA ZA2010/04769A patent/ZA201004769B/en unknown
- 2010-07-23 MA MA33047A patent/MA32183B1/fr unknown
- 2010-07-27 CR CR11601A patent/CR11601A/es not_active Application Discontinuation
- 2010-08-06 EC EC2010010389A patent/ECSP10010389A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2711699A1 (en) | 2009-07-16 |
KR20100118110A (ko) | 2010-11-04 |
AU2009204025B2 (en) | 2014-02-20 |
IL206575A0 (en) | 2010-12-30 |
JP2011509308A (ja) | 2011-03-24 |
CR11601A (es) | 2010-08-19 |
ES2422733T3 (es) | 2013-09-13 |
EP2247578A1 (en) | 2010-11-10 |
KR101624753B1 (ko) | 2016-05-26 |
NZ586346A (en) | 2012-02-24 |
ZA201004769B (en) | 2011-12-28 |
US20110065716A1 (en) | 2011-03-17 |
RU2504542C2 (ru) | 2014-01-20 |
ECSP10010389A (es) | 2010-11-30 |
CN101932564A (zh) | 2010-12-29 |
JP5346345B2 (ja) | 2013-11-20 |
CN101932564B (zh) | 2012-12-26 |
EP2247578B1 (en) | 2013-05-22 |
WO2009089459A1 (en) | 2009-07-16 |
MA32183B1 (fr) | 2011-04-01 |
BRPI0906798A2 (pt) | 2015-07-14 |
RU2010132911A (ru) | 2012-02-20 |
US8835434B2 (en) | 2014-09-16 |
AU2009204025A1 (en) | 2009-07-16 |
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