UA100544C2 - Гидроксилированный пиримидилциклопентан как ингибитор протеинкиназы акт - Google Patents

Гидроксилированный пиримидилциклопентан как ингибитор протеинкиназы акт

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Publication number
UA100544C2
UA100544C2 UAA201009870A UAA201009870A UA100544C2 UA 100544 C2 UA100544 C2 UA 100544C2 UA A201009870 A UAA201009870 A UA A201009870A UA A201009870 A UAA201009870 A UA A201009870A UA 100544 C2 UA100544 C2 UA 100544C2
Authority
UA
Ukraine
Prior art keywords
akt protein
protein kinase
kinase inhibitor
cyclopentane
hydroxylated
Prior art date
Application number
UAA201009870A
Other languages
English (en)
Ukrainian (uk)
Inventor
Йозеф Бенсік
Джеймс Ф. Блейк
Ніколас С. Каллан
Ян С. Мітчелл
Кейт Л. Спенсер
Денгмінг Хіао
Руі Ху
Крістін Чабот
Стівен До
Джун Ліанг
Браян Сафіна
Біронг Жанг
Original Assignee
Еррей Біофарма Інк.
Дженентек, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Еррей Біофарма Інк., Дженентек, Інк. filed Critical Еррей Біофарма Інк.
Publication of UA100544C2 publication Critical patent/UA100544C2/ru

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Представленное изобретение касается соединения , фармацевтической композиции на ее основе и применения как ингибитора протеинкиназы АКТ, а также применения заявленного соединения и фармацевтической композиции для лечения гиперпролиферативных заболеваний, таких как рак.
UAA201009870A 2008-01-09 2009-09-01 Гидроксилированный пиримидилциклопентан как ингибитор протеинкиназы акт UA100544C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2008708P 2008-01-09 2008-01-09
PCT/US2009/030602 WO2009089453A1 (en) 2008-01-09 2009-01-09 Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor

Publications (1)

Publication Number Publication Date
UA100544C2 true UA100544C2 (ru) 2013-01-10

Family

ID=40386151

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201009870A UA100544C2 (ru) 2008-01-09 2009-09-01 Гидроксилированный пиримидилциклопентан как ингибитор протеинкиназы акт

Country Status (20)

Country Link
US (1) US8853216B2 (ru)
EP (1) EP2240455B1 (ru)
JP (1) JP5539225B2 (ru)
KR (1) KR101624752B1 (ru)
CN (1) CN101932565B (ru)
AU (1) AU2009204019B2 (ru)
BR (1) BRPI0907372A2 (ru)
CA (1) CA2711692A1 (ru)
CO (1) CO6280510A2 (ru)
CR (1) CR11591A (ru)
EC (1) ECSP10010392A (ru)
ES (1) ES2401685T3 (ru)
HK (1) HK1149269A1 (ru)
IL (1) IL206607A0 (ru)
MA (1) MA32343B1 (ru)
MX (1) MX2010007546A (ru)
NZ (1) NZ586720A (ru)
RU (1) RU2520735C2 (ru)
UA (1) UA100544C2 (ru)
WO (1) WO2009089453A1 (ru)

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JP5635910B2 (ja) 2008-01-09 2014-12-03 アレイ バイオファーマ、インコーポレイテッド ＡＫＴタンパク質キナーゼ阻害剤としての５Ｈ−シクロペンタ［ｄ］ピリミジン
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CR11591A (es) 2010-11-30
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EP2240455B1 (en) 2012-12-26
HK1149269A1 (en) 2011-09-30
EP2240455A1 (en) 2010-10-20
MX2010007546A (es) 2010-09-30
RU2520735C2 (ru) 2014-06-27
AU2009204019A1 (en) 2009-07-16
AU2009204019B2 (en) 2014-02-20
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US8853216B2 (en) 2014-10-07
ES2401685T8 (es) 2014-11-06
CN101932565A (zh) 2010-12-29
KR101624752B1 (ko) 2016-05-26
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