MX2009010517A - Moduladores de cinasa aurora y metodos de uso. - Google Patents

Moduladores de cinasa aurora y metodos de uso.

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Publication number
MX2009010517A
MX2009010517A MX2009010517A MX2009010517A MX2009010517A MX 2009010517 A MX2009010517 A MX 2009010517A MX 2009010517 A MX2009010517 A MX 2009010517A MX 2009010517 A MX2009010517 A MX 2009010517A MX 2009010517 A MX2009010517 A MX 2009010517A
Authority
MX
Mexico
Prior art keywords
aurora kinase
compounds
influencing
disease states
modulating
Prior art date
Application number
MX2009010517A
Other languages
English (en)
Inventor
Stephanie D Geuns-Meyer
Matthew W Martin
Brian L Hodous
Victor J Cee
Holly L Deak
Hanh Nho Nguyen
Philip R Olivieri
Karina Romero
Ryan White
Bingfan Du
Laurie Schenkel
Kathleen Panter
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2009010517A publication Critical patent/MX2009010517A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos químicos que tienen una fórmula general (I) (ver fórmula (I)) en donde A1-8, D´, L1, L2, R1 R6-8 y n se definen en la presente, e intermediarios sintéticos, los cuales son capaces de modular varias enzimas receptoras de proteína cinasa y, de esta manera, de influenciar varios estados de enfermedad y afecciones relacionados con las actividades de estas cinasas. Por ejemplo, los compuestos son capaces de modular cinasa Aurora influenciando de esta manera el proceso de ciclo celular y proliferación celular para tratar cáncer y enfermedades relacionadas con cáncer. La invención incluye también composiciones farmacéuticas, que incluyen los compuestos, y métodos para tratar estados de enfermedad relacionados con la actividad de cinasa Aurora.
MX2009010517A 2007-04-05 2008-04-03 Moduladores de cinasa aurora y metodos de uso. MX2009010517A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92220507P 2007-04-05 2007-04-05
PCT/US2008/004432 WO2008124083A2 (en) 2007-04-05 2008-04-03 Aurora kinase modulators and method of use

Publications (1)

Publication Number Publication Date
MX2009010517A true MX2009010517A (es) 2009-10-19

Family

ID=39580061

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Application Number Title Priority Date Filing Date
MX2009010517A MX2009010517A (es) 2007-04-05 2008-04-03 Moduladores de cinasa aurora y metodos de uso.

Country Status (8)

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US (3) US7776857B2 (es)
EP (1) EP2137177B1 (es)
JP (1) JP5516397B2 (es)
AU (1) AU2008236670B2 (es)
CA (1) CA2682504C (es)
ES (1) ES2470341T3 (es)
MX (1) MX2009010517A (es)
WO (1) WO2008124083A2 (es)

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US20090069297A1 (en) 2009-03-12
AU2008236670B2 (en) 2011-12-01
CA2682504C (en) 2012-10-30
JP5516397B2 (ja) 2014-06-11
CA2682504A1 (en) 2008-10-16
US8557816B2 (en) 2013-10-15
US7981891B2 (en) 2011-07-19
EP2137177A2 (en) 2009-12-30
ES2470341T3 (es) 2014-06-23
EP2137177B1 (en) 2014-05-07
JP2010523568A (ja) 2010-07-15
AU2008236670A1 (en) 2008-10-16
US20100280008A1 (en) 2010-11-04
US20120122847A1 (en) 2012-05-17
WO2008124083A3 (en) 2009-01-15

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