UA104849C2 - 4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janus - Google Patents

4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janus

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Publication number
UA104849C2
UA104849C2 UAA201007505A UAA201007505A UA104849C2 UA 104849 C2 UA104849 C2 UA 104849C2 UA A201007505 A UAA201007505 A UA A201007505A UA A201007505 A UAA201007505 A UA A201007505A UA 104849 C2 UA104849 C2 UA 104849C2
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Ukraine
Prior art keywords
pyrazolyl
amines
heteroarylpyrimidin
arylpyrimidin
inhibitors
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UAA201007505A
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English (en)
Russian (ru)
Inventor
Юнь-Лун Лі
Веньцин Яо
Джеймс Д. Роджерс
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Інсайт Корпорейшн
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Application filed by Інсайт Корпорейшн filed Critical Інсайт Корпорейшн
Publication of UA104849C2 publication Critical patent/UA104849C2/uk

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Abstract

Даний винахід стосується заміщених біциклічних гетероарильних сполук формули (І), включаючи, наприклад, 4-піразоліл-N-арилпіримідин-2-аміни і 4-піразоліл-N-гетероарилпіримідин-2-аміни, які модулюють активність кіназ і застосовні при лікуванні захворювань, пов'язаних з активністю кіназ, включаючи, наприклад, хвороби, пов'язані з імунітетом, шкірні розлади, мієлоїднопроліферативні розлади, рак і інші захворювання.I
UAA201007505A 2007-11-16 2008-11-13 4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janus UA104849C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98860607P 2007-11-16 2007-11-16
PCT/US2008/083319 WO2009064835A1 (en) 2007-11-16 2008-11-13 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors

Publications (1)

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UA104849C2 true UA104849C2 (uk) 2014-03-25

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UAA201007505A UA104849C2 (uk) 2007-11-16 2008-11-13 4-піразоліл-n-арилпіримідин-2-аміни і 4-піразоліл-n-гетероарилпіримідин-2-аміни як інгібітори кіназ janus

Country Status (21)

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US (1) US8309718B2 (uk)
EP (1) EP2220068B1 (uk)
JP (1) JP5480813B2 (uk)
KR (1) KR101580482B1 (uk)
CN (1) CN101910152B (uk)
AU (1) AU2008321046B2 (uk)
BR (1) BRPI0820544A2 (uk)
CA (1) CA2704599C (uk)
CO (1) CO6280420A2 (uk)
CR (1) CR11430A (uk)
EA (1) EA020777B1 (uk)
EC (1) ECSP10010263A (uk)
ES (1) ES2569528T3 (uk)
HK (1) HK1147476A1 (uk)
IL (1) IL205571A (uk)
MX (1) MX2010005300A (uk)
MY (1) MY152948A (uk)
NZ (1) NZ585139A (uk)
UA (1) UA104849C2 (uk)
WO (1) WO2009064835A1 (uk)
ZA (1) ZA201004055B (uk)

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