MA39784B1 - Combinaisons des inhibiteurs du fgfr et du cmet destinées au traitement du cancer - Google Patents

Combinaisons des inhibiteurs du fgfr et du cmet destinées au traitement du cancer

Info

Publication number
MA39784B1
MA39784B1 MA39784A MA39784A MA39784B1 MA 39784 B1 MA39784 B1 MA 39784B1 MA 39784 A MA39784 A MA 39784A MA 39784 A MA39784 A MA 39784A MA 39784 B1 MA39784 B1 MA 39784B1
Authority
MA
Morocco
Prior art keywords
pharmaceutically acceptable
dimethoxyphenyl
pyrazol
solvate
methyl
Prior art date
Application number
MA39784A
Other languages
English (en)
Other versions
MA39784A (fr
Inventor
Eleonora Jovcheva
Timothy Pietro Suren Perera
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of MA39784A publication Critical patent/MA39784A/fr
Publication of MA39784B1 publication Critical patent/MA39784B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne une combinaison d'un premier composé choisi parmi la n-(3,5-diméthoxyphényl)-n'-(1-méthyléthyl)-n-[3-(1-méthyl-1h-pyrazol-4-yl)quinoxalin-6-yl]éthane-1,2-diamine ou un sel pharmaceutiquement acceptable de celle-ci ou un solvate de celui-ci, et la n-(2-fluoro-3,5-diméthoxyphényl)-n-(1h-imidazol-2-ylméthyl)-3-(1-méthyl-1h-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-amine ou un sel pharmaceutiquement acceptable de celle-ci ou un solvate de celui-ci ; et un deuxième composé qui est un inhibiteur de cmet. La combinaison est destinée à une utilisation dans le traitement d'un trouble prolifératif, en particulier à une utilisation dans le traitement du cancer. L'inhibiteur de fgfr (n-(3,5-diméthoxyphényl)-n'-(1-méthyléthyl)-n-[3-(1-méthyl-1h-pyrazol-4-yl)quinoxalin-6-yl]éthane-1,2-diamine ou un sel pharmaceutiquement acceptable de celle-ci ou un solvate de celui-ci, et n-(2-fluoro-3,5-diméthoxyphényl)-n-(1h-imidazol-2-ylméthyl)-3-(1-méthyl-1h-pyrazol-4-yl)pyrido[2,3-b]pyrazin-6-amine ou un sel pharmaceutiquement acceptable de celle-ci ou un solvate de celui-ci et l'inhibiteur de cmet peuvent être administrés simultanément, séparément ou séquentiellement. En outre, la présente invention concerne une composition pharmaceutique comprenant un vecteur pharmaceutiquement acceptable et une combinaison selon l'invention.
MA39784A 2014-03-26 2015-03-26 Combinaisons des inhibiteurs du fgfr et du cmet destinées au traitement du cancer MA39784B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14161835 2014-03-26
PCT/EP2015/056512 WO2015144804A1 (fr) 2014-03-26 2015-03-26 Combinaisons

Publications (2)

Publication Number Publication Date
MA39784A MA39784A (fr) 2017-02-01
MA39784B1 true MA39784B1 (fr) 2021-03-31

Family

ID=50389857

Family Applications (2)

Application Number Title Priority Date Filing Date
MA055696A MA55696A (fr) 2014-03-26 2015-03-26 Combinaisons
MA39784A MA39784B1 (fr) 2014-03-26 2015-03-26 Combinaisons des inhibiteurs du fgfr et du cmet destinées au traitement du cancer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA055696A MA55696A (fr) 2014-03-26 2015-03-26 Combinaisons

Country Status (22)

Country Link
US (3) US10085982B2 (fr)
EP (2) EP3122358B1 (fr)
JP (2) JP6752715B2 (fr)
KR (1) KR102479693B1 (fr)
CN (1) CN106458999B (fr)
AU (1) AU2015238301B2 (fr)
BR (1) BR112016022056B1 (fr)
CA (1) CA2943682C (fr)
CY (1) CY1123930T1 (fr)
DK (1) DK3122358T3 (fr)
ES (1) ES2856482T3 (fr)
HR (1) HRP20210338T1 (fr)
HU (1) HUE053654T2 (fr)
LT (1) LT3122358T (fr)
MA (2) MA55696A (fr)
MX (1) MX370099B (fr)
PL (1) PL3122358T3 (fr)
PT (1) PT3122358T (fr)
RS (1) RS61536B1 (fr)
RU (1) RU2715236C2 (fr)
SI (1) SI3122358T1 (fr)
WO (1) WO2015144804A1 (fr)

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GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
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