EA202290154A1 - Фармацевтическая композиция для лечения острого миелоидного лейкоза, содержащая ингибитор flt3 и химиотерапевтические агенты - Google Patents
Фармацевтическая композиция для лечения острого миелоидного лейкоза, содержащая ингибитор flt3 и химиотерапевтические агентыInfo
- Publication number
- EA202290154A1 EA202290154A1 EA202290154A EA202290154A EA202290154A1 EA 202290154 A1 EA202290154 A1 EA 202290154A1 EA 202290154 A EA202290154 A EA 202290154A EA 202290154 A EA202290154 A EA 202290154A EA 202290154 A1 EA202290154 A1 EA 202290154A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- pharmaceutical composition
- myeloid leukemia
- acute myeloid
- chemotherapeutic agents
- Prior art date
Links
- 208000031261 Acute myeloid leukaemia Diseases 0.000 title abstract 3
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 title 1
- 108010003374 fms-Like Tyrosine Kinase 3 Proteins 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 208000025113 myeloid leukemia Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В изобретении предлагаются фармацевтическая композиция для лечения миелоидного лейкоза (AML) и способ лечения острого миелоидного лейкоза с ее применением, при этом указанная фармацевтическая композиция содержит терапевтически эффективную комбинацию ингибитора Fms-подобной тирозинкиназы-3 (FLT3) или его фармацевтически приемлемой соли или сольвата, и химиотерапевтического агента или его фармацевтически приемлемой соли или сольвата.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20190077302 | 2019-06-27 | ||
PCT/KR2020/008258 WO2020262974A1 (ko) | 2019-06-27 | 2020-06-25 | Flt3 저해제 및 화학치료제를 포함하는 급성 골수성 백혈병 치료용 약학적 조성물 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202290154A1 true EA202290154A1 (ru) | 2022-03-29 |
Family
ID=74060307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202290154A EA202290154A1 (ru) | 2019-06-27 | 2020-06-25 | Фармацевтическая композиция для лечения острого миелоидного лейкоза, содержащая ингибитор flt3 и химиотерапевтические агенты |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220354842A1 (ru) |
EP (1) | EP3991733A4 (ru) |
JP (1) | JP2022538817A (ru) |
KR (1) | KR20210002015A (ru) |
CN (1) | CN114650823A (ru) |
AU (1) | AU2020308814A1 (ru) |
CA (1) | CA3145391A1 (ru) |
EA (1) | EA202290154A1 (ru) |
IL (1) | IL289366A (ru) |
MX (1) | MX2021015724A (ru) |
WO (1) | WO2020262974A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202246243A (zh) * | 2021-02-26 | 2022-12-01 | 美商泰拉生物科學公司 | 胺基嘧啶化合物及其使用方法 |
WO2023027966A1 (en) | 2021-08-24 | 2023-03-02 | Biomea Fusion, Inc. | Pyrazine compounds as irreversible inhibitors of flt3 |
EP4370506A1 (en) | 2021-12-30 | 2024-05-22 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
WO2023225005A1 (en) | 2022-05-17 | 2023-11-23 | Biomea Fusion, Inc. | Flt3 combination therapy for cancer and compositions therefor |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2133095A4 (en) * | 2007-03-05 | 2012-09-26 | Kyowa Hakko Kirin Co Ltd | PHARMACEUTICAL COMPOSITION |
US20110183975A1 (en) * | 2008-10-07 | 2011-07-28 | Yasuhiro Goto | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
KR101755725B1 (ko) * | 2009-03-23 | 2017-07-07 | 암비트 바이오사이언시즈 코포레이션 | 병용 요법을 이용한 치료 방법 |
US8435980B2 (en) * | 2009-07-15 | 2013-05-07 | Abbvie Inc. | Pyrrolopyridine inhibitors of kinases |
KR20180124055A (ko) | 2016-03-29 | 2018-11-20 | 아스테라스 세이야쿠 가부시키가이샤 | 급성 골수성 백혈병의 치료를 위한 병용 요법 |
KR102175710B1 (ko) | 2017-01-23 | 2020-11-06 | 주식회사 엘지화학 | 폴리아릴렌 설파이드 수지 조성물 |
BR112019015256A2 (pt) | 2017-01-26 | 2020-04-14 | Hanmi Pharm Ind Co Ltd | composto selecionado de uma substância de fórmula 1 e um sal farmaceuticamente aceitável da mesma, e composicão farmacêutica |
KR101954370B1 (ko) * | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
CN113490497A (zh) * | 2019-02-22 | 2021-10-08 | 韩美药品株式会社 | 包括flt3抑制剂和低甲基化剂的用于治疗急性髓系白血病的药物组合物 |
-
2020
- 2020-06-25 MX MX2021015724A patent/MX2021015724A/es unknown
- 2020-06-25 EP EP20833623.0A patent/EP3991733A4/en not_active Withdrawn
- 2020-06-25 US US17/622,389 patent/US20220354842A1/en active Pending
- 2020-06-25 CA CA3145391A patent/CA3145391A1/en active Pending
- 2020-06-25 EA EA202290154A patent/EA202290154A1/ru unknown
- 2020-06-25 AU AU2020308814A patent/AU2020308814A1/en active Pending
- 2020-06-25 WO PCT/KR2020/008258 patent/WO2020262974A1/ko active Application Filing
- 2020-06-25 KR KR1020200078053A patent/KR20210002015A/ko active Search and Examination
- 2020-06-25 JP JP2021576034A patent/JP2022538817A/ja active Pending
- 2020-06-25 CN CN202080058522.0A patent/CN114650823A/zh active Pending
-
2021
- 2021-12-24 IL IL289366A patent/IL289366A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN114650823A (zh) | 2022-06-21 |
EP3991733A1 (en) | 2022-05-04 |
CA3145391A1 (en) | 2020-12-30 |
JP2022538817A (ja) | 2022-09-06 |
KR20210002015A (ko) | 2021-01-06 |
EP3991733A4 (en) | 2023-07-05 |
US20220354842A1 (en) | 2022-11-10 |
AU2020308814A1 (en) | 2022-02-03 |
WO2020262974A1 (ko) | 2020-12-30 |
IL289366A (en) | 2022-02-01 |
MX2021015724A (es) | 2022-05-16 |
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