HK1147476A1 - 作為 烟魯綠 激酶抑制劑的 -吡唑基- -芳基嘧啶- -胺類以及 -吡唑基- -雜芳基嘧啶- -胺類 - Google Patents
作為 烟魯綠 激酶抑制劑的 -吡唑基- -芳基嘧啶- -胺類以及 -吡唑基- -雜芳基嘧啶- -胺類Info
- Publication number
- HK1147476A1 HK1147476A1 HK11101335.9A HK11101335A HK1147476A1 HK 1147476 A1 HK1147476 A1 HK 1147476A1 HK 11101335 A HK11101335 A HK 11101335A HK 1147476 A1 HK1147476 A1 HK 1147476A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyrazolyl
- amines
- janus
- heteroarylpyrimidin
- arylpyrimidin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Diabetes (AREA)
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- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98860607P | 2007-11-16 | 2007-11-16 | |
PCT/US2008/083319 WO2009064835A1 (en) | 2007-11-16 | 2008-11-13 | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1147476A1 true HK1147476A1 (zh) | 2011-08-12 |
Family
ID=40380038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11101335.9A HK1147476A1 (zh) | 2007-11-16 | 2011-02-11 | 作為 烟魯綠 激酶抑制劑的 -吡唑基- -芳基嘧啶- -胺類以及 -吡唑基- -雜芳基嘧啶- -胺類 |
Country Status (21)
Country | Link |
---|---|
US (1) | US8309718B2 (zh) |
EP (1) | EP2220068B1 (zh) |
JP (1) | JP5480813B2 (zh) |
KR (1) | KR101580482B1 (zh) |
CN (1) | CN101910152B (zh) |
AU (1) | AU2008321046B2 (zh) |
BR (1) | BRPI0820544A2 (zh) |
CA (1) | CA2704599C (zh) |
CO (1) | CO6280420A2 (zh) |
CR (1) | CR11430A (zh) |
EA (1) | EA020777B1 (zh) |
EC (1) | ECSP10010263A (zh) |
ES (1) | ES2569528T3 (zh) |
HK (1) | HK1147476A1 (zh) |
IL (1) | IL205571A (zh) |
MX (1) | MX2010005300A (zh) |
MY (1) | MY152948A (zh) |
NZ (1) | NZ585139A (zh) |
UA (1) | UA104849C2 (zh) |
WO (1) | WO2009064835A1 (zh) |
ZA (1) | ZA201004055B (zh) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060106020A1 (en) * | 2004-04-28 | 2006-05-18 | Rodgers James D | Tetracyclic inhibitors of Janus kinases |
HUE030235T2 (en) | 2005-12-13 | 2017-04-28 | Incyte Holdings Corp | Heteroaryl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors |
WO2008079965A1 (en) | 2006-12-22 | 2008-07-03 | Incyte Corporation | Substituted heterocycles as janus kinase inhibitors |
EP3070090B1 (en) | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
FR2938537B1 (fr) | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique. |
JOP20190231A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
EA020494B1 (ru) | 2009-05-22 | 2014-11-28 | Инсайт Корпорейшн | 3-[4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ]ОКТАН- ИЛИ ГЕПТАННИТРИЛ КАК JAK-ИНГИБИТОРЫ |
AR076794A1 (es) | 2009-05-22 | 2011-07-06 | Incyte Corp | Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen |
AR078012A1 (es) | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
WO2011079231A1 (en) * | 2009-12-23 | 2011-06-30 | Gatekeeper Pharmaceutical, Inc. | Compounds that modulate egfr activity and methods for treating or preventing conditions therewith |
AU2011214254B2 (en) * | 2010-02-10 | 2016-06-09 | Genon Biotechnologies Oy | Dual activity kinase domains and uses thereof |
BR112012020693B1 (pt) * | 2010-02-18 | 2020-05-12 | Incyte Holdings Corporation | Derivados de ciclobutano e metilciclobutano como inibidores de janus quinase e composição que os compreende |
MX347851B (es) | 2010-03-10 | 2017-05-16 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
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- 2008-11-13 EP EP08848610.5A patent/EP2220068B1/en active Active
- 2008-11-13 UA UAA201007505A patent/UA104849C2/uk unknown
-
2010
- 2010-05-06 IL IL205571A patent/IL205571A/en active IP Right Grant
- 2010-05-14 CR CR11430A patent/CR11430A/es unknown
- 2010-05-26 CO CO10063312A patent/CO6280420A2/es active IP Right Grant
- 2010-06-07 ZA ZA2010/04055A patent/ZA201004055B/en unknown
- 2010-06-16 EC EC2010010263A patent/ECSP10010263A/es unknown
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2011
- 2011-02-11 HK HK11101335.9A patent/HK1147476A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
UA104849C2 (uk) | 2014-03-25 |
CR11430A (es) | 2010-07-01 |
EP2220068A1 (en) | 2010-08-25 |
WO2009064835A1 (en) | 2009-05-22 |
US8309718B2 (en) | 2012-11-13 |
IL205571A (en) | 2015-09-24 |
JP2011503194A (ja) | 2011-01-27 |
CN101910152B (zh) | 2014-08-06 |
ECSP10010263A (es) | 2010-07-30 |
ES2569528T3 (es) | 2016-05-11 |
US20090318405A1 (en) | 2009-12-24 |
BRPI0820544A2 (pt) | 2015-06-16 |
EA201070618A1 (ru) | 2010-12-30 |
NZ585139A (en) | 2012-05-25 |
CN101910152A (zh) | 2010-12-08 |
MY152948A (en) | 2014-12-15 |
AU2008321046A1 (en) | 2009-05-22 |
ZA201004055B (en) | 2012-09-26 |
KR20100095582A (ko) | 2010-08-31 |
CO6280420A2 (es) | 2011-05-20 |
IL205571A0 (en) | 2010-12-30 |
MX2010005300A (es) | 2010-06-25 |
AU2008321046B2 (en) | 2013-10-24 |
CA2704599A1 (en) | 2009-05-22 |
JP5480813B2 (ja) | 2014-04-23 |
EA020777B1 (ru) | 2015-01-30 |
EP2220068B1 (en) | 2016-01-27 |
KR101580482B1 (ko) | 2015-12-28 |
CA2704599C (en) | 2015-05-12 |
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