MX2018016331A - Formas cristalinas de compuesto de triazolopirimidina. - Google Patents
Formas cristalinas de compuesto de triazolopirimidina.Info
- Publication number
- MX2018016331A MX2018016331A MX2018016331A MX2018016331A MX2018016331A MX 2018016331 A MX2018016331 A MX 2018016331A MX 2018016331 A MX2018016331 A MX 2018016331A MX 2018016331 A MX2018016331 A MX 2018016331A MX 2018016331 A MX2018016331 A MX 2018016331A
- Authority
- MX
- Mexico
- Prior art keywords
- crystalline forms
- triazolopyrimidine compound
- triazolopyrimidine
- compound
- prc2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En la presente se proporcionan formas cristalinas de un compuesto de triazolopirimidina, que son útiles para el tratamiento de una enfermedad o trastorno mediado por PRC2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2016086350 | 2016-06-20 | ||
PCT/CN2017/089003 WO2017219948A1 (en) | 2016-06-20 | 2017-06-19 | Crystalline forms of triazolopyrimidine compound |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018016331A true MX2018016331A (es) | 2019-05-20 |
Family
ID=60783815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018016331A MX2018016331A (es) | 2016-06-20 | 2017-06-19 | Formas cristalinas de compuesto de triazolopirimidina. |
Country Status (14)
Country | Link |
---|---|
US (2) | US11091489B2 (es) |
EP (1) | EP3472168B1 (es) |
JP (1) | JP7042812B2 (es) |
KR (1) | KR102519922B1 (es) |
CN (1) | CN109563100B (es) |
AU (1) | AU2017282871B2 (es) |
BR (1) | BR112018076443A2 (es) |
CA (1) | CA3027246A1 (es) |
CL (2) | CL2018003734A1 (es) |
IL (1) | IL263429B (es) |
MX (1) | MX2018016331A (es) |
RU (1) | RU2754856C2 (es) |
SA (1) | SA518400704B1 (es) |
WO (1) | WO2017219948A1 (es) |
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ES2928856T3 (es) | 2015-11-19 | 2022-11-23 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
UA126113C2 (uk) | 2015-12-22 | 2022-08-17 | Інсайт Корпорейшн | Гетероциклічні сполуки як імуномодулятори |
WO2017192961A1 (en) | 2016-05-06 | 2017-11-09 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
EP3464279B1 (en) | 2016-05-26 | 2021-11-24 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2017222976A1 (en) | 2016-06-20 | 2017-12-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
US20180179179A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
BR112019012957A2 (pt) | 2016-12-22 | 2019-11-26 | Incyte Corp | derivados de tetra-hidroimidazo[4,5-c]piridina como indutores de internalização de pd-l1 |
ES2874756T3 (es) | 2016-12-22 | 2021-11-05 | Incyte Corp | Derivados de triazolo[1,5-A]piridina como inmunomoduladores |
AU2017382870B2 (en) | 2016-12-22 | 2022-03-24 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
PT3746446T (pt) * | 2018-01-31 | 2022-07-18 | Mirati Therapeutics Inc | Inibidores de prc2 |
CN110156787B (zh) * | 2018-02-13 | 2021-11-02 | 中国科学院上海药物研究所 | 一种三氮唑并嘧啶衍生化合物、包含其的药物组合物及其用途 |
SI3774791T1 (sl) | 2018-03-30 | 2023-04-28 | Incyte Corporation | Heterociklične spojine kot imunomodulatorji |
DK3790877T3 (da) | 2018-05-11 | 2023-04-24 | Incyte Corp | Tetrahydro-imidazo[4,5-c]pyridinderivater som pd-l1-immunmodulatorer |
CN111518100A (zh) * | 2019-02-02 | 2020-08-11 | 上海青煜医药科技有限公司 | 环丙烯并苯并呋喃取代的氮杂芳基化合物及其应用 |
CA3150434A1 (en) | 2019-08-09 | 2021-02-18 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
AU2020332462B2 (en) * | 2019-08-22 | 2023-08-17 | Shanghai Blueray Biopharma Co., Ltd. | Azaheteroaryl compound and application thereof |
BR112022005826A2 (pt) | 2019-09-30 | 2022-06-21 | Incyte Corp | Compostos de pirido[3,2-d]pirimidina como imunomoduladores |
CN110796297B (zh) * | 2019-10-21 | 2020-11-10 | 浙江大学 | 一种基于平衡度方差和可靠度的电力系统结构优化方法 |
KR20220097449A (ko) * | 2019-11-01 | 2022-07-07 | 상하이테크 유니버시티 | Eed 억제제, 및 이의 제조방법 및 용도 |
MX2022005651A (es) | 2019-11-11 | 2022-07-27 | Incyte Corp | Sales y formas cristalinas de un inhibidor de la proteina de muerte celular programada 1 (pd-1)/ligando de muerte celular programada 1 (pd-l1). |
CN115916209A (zh) * | 2020-05-28 | 2023-04-04 | 诺华股份有限公司 | 用于治疗PRC2介导的疾病或障碍的N-((5-氟-2,3-二氢苯并呋喃-4-基)甲基)-8-(2-甲基吡啶-3-基)-[1,2,4]三唑并[4,3-c]嘧啶-5-胺或其药学上可接受的盐的给药方案 |
CN114426541B (zh) * | 2020-10-29 | 2023-06-30 | 成都先导药物开发股份有限公司 | 氮杂芳基化合物及其用途 |
US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
JP2023548859A (ja) | 2020-11-06 | 2023-11-21 | インサイト・コーポレイション | Pd-1/pd-l1阻害剤ならびにその塩及び結晶形態を作製するためのプロセス |
WO2022105852A1 (zh) | 2020-11-20 | 2022-05-27 | 江苏恒瑞医药股份有限公司 | 三嗪二酮类衍生物、其制备方法及其在医药上的应用 |
CN114907385A (zh) | 2021-02-10 | 2022-08-16 | 上海青煜医药科技有限公司 | 氮杂芳基化合物、其制备方法及应用 |
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-
2017
- 2017-06-19 IL IL263429A patent/IL263429B/en unknown
- 2017-06-19 EP EP17814686.6A patent/EP3472168B1/en active Active
- 2017-06-19 CA CA3027246A patent/CA3027246A1/en active Pending
- 2017-06-19 MX MX2018016331A patent/MX2018016331A/es unknown
- 2017-06-19 JP JP2019518348A patent/JP7042812B2/ja active Active
- 2017-06-19 US US16/311,638 patent/US11091489B2/en active Active
- 2017-06-19 AU AU2017282871A patent/AU2017282871B2/en active Active
- 2017-06-19 CN CN201780050951.1A patent/CN109563100B/zh active Active
- 2017-06-19 WO PCT/CN2017/089003 patent/WO2017219948A1/en unknown
- 2017-06-19 RU RU2019101220A patent/RU2754856C2/ru active
- 2017-06-19 BR BR112018076443-4A patent/BR112018076443A2/pt active Search and Examination
- 2017-06-19 KR KR1020197001451A patent/KR102519922B1/ko active IP Right Grant
-
2018
- 2018-12-20 SA SA518400704A patent/SA518400704B1/ar unknown
- 2018-12-20 CL CL2018003734A patent/CL2018003734A1/es unknown
-
2020
- 2020-09-02 CL CL2020002277A patent/CL2020002277A1/es unknown
-
2021
- 2021-07-09 US US17/371,399 patent/US11548897B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20190211022A1 (en) | 2019-07-11 |
EP3472168A4 (en) | 2019-12-11 |
CL2018003734A1 (es) | 2019-02-15 |
RU2754856C2 (ru) | 2021-09-08 |
RU2019101220A3 (es) | 2020-10-28 |
JP2019522051A (ja) | 2019-08-08 |
EP3472168A1 (en) | 2019-04-24 |
CA3027246A1 (en) | 2017-12-28 |
CL2020002277A1 (es) | 2021-02-12 |
SA518400704B1 (ar) | 2022-11-03 |
IL263429A (en) | 2018-12-31 |
US11091489B2 (en) | 2021-08-17 |
KR20190020753A (ko) | 2019-03-04 |
EP3472168B1 (en) | 2024-01-10 |
BR112018076443A2 (pt) | 2019-04-09 |
US20210340152A1 (en) | 2021-11-04 |
AU2017282871A1 (en) | 2018-12-20 |
CN109563100A (zh) | 2019-04-02 |
CN109563100B (zh) | 2021-08-27 |
IL263429B (en) | 2022-08-01 |
WO2017219948A1 (en) | 2017-12-28 |
JP7042812B2 (ja) | 2022-03-28 |
US11548897B2 (en) | 2023-01-10 |
KR102519922B1 (ko) | 2023-04-11 |
AU2017282871B2 (en) | 2020-03-05 |
RU2019101220A (ru) | 2020-07-21 |
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