EA201591610A1 - Ингибиторы кинуренинового пути - Google Patents

Ингибиторы кинуренинового пути

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Publication number
EA201591610A1
EA201591610A1 EA201591610A EA201591610A EA201591610A1 EA 201591610 A1 EA201591610 A1 EA 201591610A1 EA 201591610 A EA201591610 A EA 201591610A EA 201591610 A EA201591610 A EA 201591610A EA 201591610 A1 EA201591610 A1 EA 201591610A1
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EA
Eurasian Patent Office
Prior art keywords
dioxygenase
disease
compounds
indole
another embodiment
Prior art date
Application number
EA201591610A
Other languages
English (en)
Inventor
Монали Банерджи
Сандип Миддья
Ритеш Шривастава
Сушил Раина
Арджун Сурья
Дхармендра Б. Ядав
Веджендра К. Ядав
Камаль Кишор Капоор
Аранапакам Венкатесан
Роджер А. Смит
Скотт К. Томпсон
Original Assignee
Курадев Фарма Прайвит Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Курадев Фарма Прайвит Лтд. filed Critical Курадев Фарма Прайвит Лтд.
Publication of EA201591610A1 publication Critical patent/EA201591610A1/ru

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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Данная заявка предусматривает новые ингибиторы индоламин-2,3-диоксигеназы-1 и/или индоламин-2,3-диоксигеназы-2 и/или триптофан-2,3-диоксигеназы, их метаболиты и фармацевтически приемлемые соли или их пролекарства. Также предусмотрены способы получения этих соединений. Терапевтически эффективное количество одного или более чем одного из соединений формулы (I) может использоваться для лечения заболеваний, возникших в результате нарушения регуляции кинуренинового пути. Соединения формулы (I) действуют путем ингибирования ферментативной активности или экспрессии индоламин-2,3-диоксигеназы-1 и/или индоламин-2,3-диоксигеназы-2 и/или триптофан-2,3-диоксигеназы. Действуя таким образом, эти соединения являются эффективными в лечении заболеваний, связанных с нарушением регуляции кинуренинового пути. С помощью этих соединений можно лечить различные заболевания, включая заболевания, которые характеризуются аномальной иммунной супрессией, аномальной клеточной пролиферацией и/или воспалением. В одном воплощении заболевание представляет собой рак. В другом воплощении заболевание представляет собой вирусную инфекцию. В еще одном воплощении заболевание представляет собой депрессию. В еще одном воплощении заболевание представляет собой болезнь Альцгеймера.
EA201591610A 2013-03-14 2014-03-12 Ингибиторы кинуренинового пути EA201591610A1 (ru)

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