PE20151719A1 - Inhibidores de la ruta de quinurenina - Google Patents

Inhibidores de la ruta de quinurenina

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Publication number
PE20151719A1
PE20151719A1 PE2015001951A PE2015001951A PE20151719A1 PE 20151719 A1 PE20151719 A1 PE 20151719A1 PE 2015001951 A PE2015001951 A PE 2015001951A PE 2015001951 A PE2015001951 A PE 2015001951A PE 20151719 A1 PE20151719 A1 PE 20151719A1
Authority
PE
Peru
Prior art keywords
dioxygenase
compounds
indoleamine
kinurenine
dysregulation
Prior art date
Application number
PE2015001951A
Other languages
English (en)
Inventor
Monali Banerje
Sandip Middya
Ritesh Shrivastava
Sushil Raina
Arjun Surya
Dharmendra B Yadav
Veejendra K Yadav
Kamal Kishore Kapoor
Aranapakam Venkatesan
Roger A Smith
Scott K Thompson
Original Assignee
Curadev Pharma Private Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curadev Pharma Private Ltd filed Critical Curadev Pharma Private Ltd
Publication of PE20151719A1 publication Critical patent/PE20151719A1/es

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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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Abstract

La presente solicitud proporciona nuevos inhibidores de indoleamina 2,3-dioxigenasa-1 y/o indoleamina 2,3-dioxigenasa-2 y/o triptofano 2,3-dioxigenasa, metabolitos de las mismas, y sales o profarmacos farmaceuticamente aceptables de los mismos. Tambien se proporcionan metodos para preparar estos compuestos. Una cantidad terapeuticamente eficaz de uno o mas de los compuestos de formula (I) es util para tratar enfermedades resultantes de la desregulacion de la ruta de quinurenina. Los compuestos de formula (I) actuan inhibiendo la actividad enzimatica o la expresion de indoleamina 2,3-dioxigenasa-1 y/o indoleamina 2,3-dioxigenasa-2 y/o triptofano 2,3-dioxigenasa. Al hacerlo, estos compuestos son eficaces para tratar enfermedades asociadas con la desregulacion de la ruta de quinurenina. Puede tratarse una diversidad de enfermedades usando estos compuestos e incluyen enfermedades que se caracterizan por la supresion inmune, la proliferacion celular anormal y/o la inflamacion tales como cancer, una infeccion viral, depresion, enfermedad es enfermedad de Alzheimer, entre otras
PE2015001951A 2013-03-14 2014-03-12 Inhibidores de la ruta de quinurenina PE20151719A1 (es)

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