GT201500294A - Compuestos de biaril-amida como inhibidores de cinasa - Google Patents
Compuestos de biaril-amida como inhibidores de cinasaInfo
- Publication number
- GT201500294A GT201500294A GT201500294A GT201500294A GT201500294A GT 201500294 A GT201500294 A GT 201500294A GT 201500294 A GT201500294 A GT 201500294A GT 201500294 A GT201500294 A GT 201500294A GT 201500294 A GT201500294 A GT 201500294A
- Authority
- GT
- Guatemala
- Prior art keywords
- compounds
- biaril
- cinasa
- inhibitors
- amida
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D233/88—Nitrogen atoms, e.g. allantoin
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Abstract
LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS QUE INHIBEN LAS CINASAS RAF Y, DE CONFORMIDAD CON LO ANTERIOR, SON ÚTILES PARA EL TRATAMIENTO DE CIERTOS TRASTORNOS ASOCIADOS CON UNA ACTIVIDAD EXCESIVA DE LA CINASA RAF, ONCLUYENDO LOS TRASTORNOS DE ROLIFERACIÓN CELULAR, TALES COMO LOS CÁNCERES. LA INVENCIÓN PROPORCIONA ADEMÁS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN ESTOS COMPUESTOS, Y LOS MÉTODOS PARA UTILIZAR ESTOS COMPUESTOS PARA TRATAR AFECCIONES, INCLUYENDO CÁNCER.
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TW201414704A (zh) | 2012-07-02 | 2014-04-16 | Biogen Idec Inc | 作爲ROR-γ受體之反向促效劑之含聯芳化合物 |
US9586948B2 (en) | 2012-10-08 | 2017-03-07 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
EP3191478B1 (en) | 2014-09-12 | 2019-05-08 | Novartis AG | Compounds and compositions as raf kinase inhibitors |
EP3191467B1 (en) | 2014-09-12 | 2020-10-21 | Novartis AG | Compounds and compositions as kinase inhibitors |
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