UY35625A - Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa - Google Patents

Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa

Info

Publication number
UY35625A
UY35625A UY0001035625A UY35625A UY35625A UY 35625 A UY35625 A UY 35625A UY 0001035625 A UY0001035625 A UY 0001035625A UY 35625 A UY35625 A UY 35625A UY 35625 A UY35625 A UY 35625A
Authority
UY
Uruguay
Prior art keywords
compounds
carboxamida
tetrahydrocarbazol
carbazol
compounds replaced
Prior art date
Application number
UY0001035625A
Other languages
English (en)
Inventor
Joseph A Tino
Anurag S Srivastava
Soo Sung Ko
Michael A Galella
Charles M Langevine
Delucca George
Liu Qingjie
Douglas A Batt
Scott Hunter Watterson
Shi Qing
Myra Beaudoin Bertrand
Original Assignee
Bristol Myers Squibb Company Una Corporación Del Estado De Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Company Una Corporación Del Estado De Delaware filed Critical Bristol Myers Squibb Company Una Corporación Del Estado De Delaware
Publication of UY35625A publication Critical patent/UY35625A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Se describen los compuestos de la Fórmula (I) Donde, las líneas punteadas, Q, R1 y R2 son sustituyentes tales como se reivindican. También se describen métodos para usar tales compuestos como inhibidores de la tirosina quinasa de Bruton (Btk), y com posiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles para el tratamiento, la prevención o la ralentización de la progresión de enfermedades o trastornos en varias áreas terapéuticas, tales como enfermedades autoinmunitarias y vasculares.
UY0001035625A 2013-06-25 2014-06-24 Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa UY35625A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361839141P 2013-06-25 2013-06-25

Publications (1)

Publication Number Publication Date
UY35625A true UY35625A (es) 2014-12-31

Family

ID=51210830

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035625A UY35625A (es) 2013-06-25 2014-06-24 Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa

Country Status (31)

Country Link
US (6) US9334290B2 (es)
EP (1) EP3013814B1 (es)
JP (1) JP6353529B2 (es)
KR (1) KR102346508B1 (es)
CN (1) CN105358546B (es)
AR (1) AR096721A1 (es)
AU (1) AU2014302548B2 (es)
BR (1) BR112015030723A8 (es)
CA (1) CA2916500A1 (es)
CL (1) CL2015003635A1 (es)
CY (1) CY1119371T1 (es)
DK (1) DK3013814T3 (es)
EA (1) EA026729B1 (es)
ES (1) ES2636652T3 (es)
HK (1) HK1223359A1 (es)
HR (1) HRP20171031T1 (es)
HU (1) HUE034460T2 (es)
IL (1) IL243296B (es)
LT (1) LT3013814T (es)
MA (1) MA38648B1 (es)
MY (1) MY176631A (es)
PE (1) PE20160519A1 (es)
PH (1) PH12015502630A1 (es)
PL (1) PL3013814T3 (es)
PT (1) PT3013814T (es)
RS (1) RS56371B1 (es)
SI (1) SI3013814T1 (es)
TN (1) TN2015000529A1 (es)
TW (1) TWI648272B (es)
UY (1) UY35625A (es)
WO (1) WO2014210085A1 (es)

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EP3789040A4 (en) 2018-04-27 2022-03-09 ONO Pharmaceutical Co., Ltd. PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASES WITH A COMPOUND WITH BTK INHIBITING ACTIVITY AS AN INGREDIENT
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Also Published As

Publication number Publication date
HRP20171031T1 (hr) 2017-10-06
CY1119371T1 (el) 2018-02-14
US20190023719A1 (en) 2019-01-24
US20140378475A1 (en) 2014-12-25
EA201592287A1 (ru) 2016-06-30
WO2014210085A9 (en) 2015-12-23
AR096721A1 (es) 2016-01-27
PE20160519A1 (es) 2016-05-21
WO2014210085A1 (en) 2014-12-31
MA38648A1 (fr) 2017-09-29
TN2015000529A1 (en) 2017-04-06
PL3013814T3 (pl) 2017-11-30
US9850258B2 (en) 2017-12-26
ES2636652T3 (es) 2017-10-06
PH12015502630A1 (en) 2016-03-07
EP3013814A1 (en) 2016-05-04
MA38648B1 (fr) 2018-06-29
CL2015003635A1 (es) 2016-07-29
TWI648272B (zh) 2019-01-21
US9334290B2 (en) 2016-05-10
DK3013814T3 (en) 2017-09-25
PT3013814T (pt) 2017-08-10
TW201536774A (zh) 2015-10-01
JP2016523907A (ja) 2016-08-12
KR20160022889A (ko) 2016-03-02
SI3013814T1 (sl) 2017-08-31
EA026729B1 (ru) 2017-05-31
LT3013814T (lt) 2017-08-10
IL243296B (en) 2018-05-31
MY176631A (en) 2020-08-19
KR102346508B1 (ko) 2022-01-03
JP6353529B2 (ja) 2018-07-04
HK1223359A1 (zh) 2017-07-28
US20180079758A1 (en) 2018-03-22
US20190382416A1 (en) 2019-12-19
US20160194338A1 (en) 2016-07-07
US10435415B2 (en) 2019-10-08
BR112015030723A2 (pt) 2017-07-25
CN105358546B (zh) 2017-10-31
AU2014302548A1 (en) 2016-02-11
CN105358546A (zh) 2016-02-24
BR112015030723A8 (pt) 2020-01-07
AU2014302548B2 (en) 2018-05-10
US10106559B2 (en) 2018-10-23
EP3013814B1 (en) 2017-06-14
HUE034460T2 (en) 2018-02-28
CA2916500A1 (en) 2014-12-31
RS56371B1 (sr) 2017-12-29
US20170283438A1 (en) 2017-10-05

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