CL2015003635A1 - Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos útiles como inhibidores de quinasa. - Google Patents

Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos útiles como inhibidores de quinasa.

Info

Publication number
CL2015003635A1
CL2015003635A1 CL2015003635A CL2015003635A CL2015003635A1 CL 2015003635 A1 CL2015003635 A1 CL 2015003635A1 CL 2015003635 A CL2015003635 A CL 2015003635A CL 2015003635 A CL2015003635 A CL 2015003635A CL 2015003635 A1 CL2015003635 A1 CL 2015003635A1
Authority
CL
Chile
Prior art keywords
tetrahydrocarbazole
kinase inhibitors
compounds useful
carboxamide compounds
substituted carboxamide
Prior art date
Application number
CL2015003635A
Other languages
English (en)
Inventor
George V Delucca
Douglas G Batt
Joseph A Tino
Anurag S Srivastava
Soo Sung Ko
Michael A Galella
Charles M Langevine
Qingje Liu
Scott Hunter Watterson
Qing Shi
Myra Beaudoin Bertrand
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CL2015003635A1 publication Critical patent/CL2015003635A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

COMPUESTOS DERIVADOS DE TETRAHIDROCARBAZOL Y CARBAZOL CARBOXAMIDA SUSTITUIDOS, COMO INHIBIDORES DE QUINASA; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; Y SU USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD AUTOINMUNE O INFLAMATORIA CRONICA.
CL2015003635A 2013-06-25 2015-12-15 Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos útiles como inhibidores de quinasa. CL2015003635A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361839141P 2013-06-25 2013-06-25

Publications (1)

Publication Number Publication Date
CL2015003635A1 true CL2015003635A1 (es) 2016-07-29

Family

ID=51210830

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015003635A CL2015003635A1 (es) 2013-06-25 2015-12-15 Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos útiles como inhibidores de quinasa.

Country Status (31)

Country Link
US (6) US9334290B2 (es)
EP (1) EP3013814B1 (es)
JP (1) JP6353529B2 (es)
KR (1) KR102346508B1 (es)
CN (1) CN105358546B (es)
AR (1) AR096721A1 (es)
AU (1) AU2014302548B2 (es)
BR (1) BR112015030723A8 (es)
CA (1) CA2916500A1 (es)
CL (1) CL2015003635A1 (es)
CY (1) CY1119371T1 (es)
DK (1) DK3013814T3 (es)
EA (1) EA026729B1 (es)
ES (1) ES2636652T3 (es)
HK (1) HK1223359A1 (es)
HR (1) HRP20171031T1 (es)
HU (1) HUE034460T2 (es)
IL (1) IL243296B (es)
LT (1) LT3013814T (es)
MA (1) MA38648B1 (es)
MY (1) MY176631A (es)
PE (1) PE20160519A1 (es)
PH (1) PH12015502630A1 (es)
PL (1) PL3013814T3 (es)
PT (1) PT3013814T (es)
RS (1) RS56371B1 (es)
SI (1) SI3013814T1 (es)
TN (1) TN2015000529A1 (es)
TW (1) TWI648272B (es)
UY (1) UY35625A (es)
WO (1) WO2014210085A1 (es)

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AR102426A1 (es) 2014-10-24 2017-03-01 Bristol Myers Squibb Co Compuestos de indolcarboxamida como inhibidores de btk
CN107108555B (zh) 2014-10-24 2020-12-01 百时美施贵宝公司 三环阻转异构体化合物
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WO2019208805A1 (ja) 2018-04-27 2019-10-31 小野薬品工業株式会社 Ｂｔｋ阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および／または治療剤
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Also Published As

Publication number Publication date
BR112015030723A8 (pt) 2020-01-07
TW201536774A (zh) 2015-10-01
US20140378475A1 (en) 2014-12-25
KR20160022889A (ko) 2016-03-02
CN105358546B (zh) 2017-10-31
TWI648272B (zh) 2019-01-21
US20190382416A1 (en) 2019-12-19
HK1223359A1 (zh) 2017-07-28
MA38648B1 (fr) 2018-06-29
US10106559B2 (en) 2018-10-23
MY176631A (en) 2020-08-19
PE20160519A1 (es) 2016-05-21
EP3013814B1 (en) 2017-06-14
WO2014210085A9 (en) 2015-12-23
BR112015030723A2 (pt) 2017-07-25
US9334290B2 (en) 2016-05-10
PH12015502630A1 (en) 2016-03-07
MA38648A1 (fr) 2017-09-29
AU2014302548B2 (en) 2018-05-10
AU2014302548A1 (en) 2016-02-11
ES2636652T3 (es) 2017-10-06
KR102346508B1 (ko) 2022-01-03
RS56371B1 (sr) 2017-12-29
PL3013814T3 (pl) 2017-11-30
EA026729B1 (ru) 2017-05-31
US9850258B2 (en) 2017-12-26
UY35625A (es) 2014-12-31
HRP20171031T1 (hr) 2017-10-06
SI3013814T1 (sl) 2017-08-31
TN2015000529A1 (en) 2017-04-06
US20180079758A1 (en) 2018-03-22
JP6353529B2 (ja) 2018-07-04
PT3013814T (pt) 2017-08-10
LT3013814T (lt) 2017-08-10
EP3013814A1 (en) 2016-05-04
IL243296B (en) 2018-05-31
DK3013814T3 (en) 2017-09-25
WO2014210085A1 (en) 2014-12-31
CA2916500A1 (en) 2014-12-31
EA201592287A1 (ru) 2016-06-30
US20160194338A1 (en) 2016-07-07
AR096721A1 (es) 2016-01-27
HUE034460T2 (en) 2018-02-28
CY1119371T1 (el) 2018-02-14
CN105358546A (zh) 2016-02-24
US20170283438A1 (en) 2017-10-05
JP2016523907A (ja) 2016-08-12
US10435415B2 (en) 2019-10-08
US20190023719A1 (en) 2019-01-24

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