BRPI0922565A2 - compostos de carbazol carboxamida úteis como inibidores de cinase - Google Patents
compostos de carbazol carboxamida úteis como inibidores de cinaseInfo
- Publication number
- BRPI0922565A2 BRPI0922565A2 BRPI0922565A BRPI0922565A BRPI0922565A2 BR PI0922565 A2 BRPI0922565 A2 BR PI0922565A2 BR PI0922565 A BRPI0922565 A BR PI0922565A BR PI0922565 A BRPI0922565 A BR PI0922565A BR PI0922565 A2 BRPI0922565 A2 BR PI0922565A2
- Authority
- BR
- Brazil
- Prior art keywords
- kinase inhibitors
- compounds useful
- carboxamide compounds
- carbazole carboxamide
- carbazole
- Prior art date
Links
- GFHHIWFKWFBNRU-UHFFFAOYSA-N 9h-carbazole-1-carboxamide Chemical class C12=CC=CC=C2NC2=C1C=CC=C2C(=O)N GFHHIWFKWFBNRU-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13904708P | 2008-12-19 | 2008-12-19 | |
PCT/US2009/068415 WO2010080481A1 (en) | 2008-12-19 | 2009-12-17 | Carbazole carboxamide compounds useful as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0922565A2 true BRPI0922565A2 (pt) | 2015-12-15 |
Family
ID=41622163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0922565A BRPI0922565A2 (pt) | 2008-12-19 | 2009-12-17 | compostos de carbazol carboxamida úteis como inibidores de cinase |
Country Status (22)
Country | Link |
---|---|
US (2) | US8084620B2 (pt) |
EP (1) | EP2391602B1 (pt) |
JP (1) | JP5487214B2 (pt) |
KR (1) | KR20110098827A (pt) |
CN (1) | CN102325753B (pt) |
AR (1) | AR074812A1 (pt) |
AU (1) | AU2009335821A1 (pt) |
BR (1) | BRPI0922565A2 (pt) |
CA (1) | CA2747670A1 (pt) |
CL (1) | CL2011001516A1 (pt) |
CO (1) | CO6390055A2 (pt) |
EA (1) | EA019041B1 (pt) |
ES (1) | ES2443948T3 (pt) |
IL (1) | IL213185A0 (pt) |
MX (1) | MX2011006171A (pt) |
NZ (1) | NZ593096A (pt) |
PE (1) | PE20110819A1 (pt) |
SG (1) | SG171815A1 (pt) |
TN (1) | TN2011000274A1 (pt) |
TW (1) | TW201028401A (pt) |
WO (1) | WO2010080481A1 (pt) |
ZA (1) | ZA201104469B (pt) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007136790A2 (en) * | 2006-05-18 | 2007-11-29 | Mannkind Corporation | Intracellular kinase inhibitors |
SG171815A1 (en) * | 2008-12-19 | 2011-07-28 | Bristol Myers Squibb Co | Carbazole carboxamide compounds useful as kinase inhibitors |
NZ598985A (en) | 2009-09-04 | 2013-07-26 | Biogen Idec Inc | Bruton's tyrosine kinase inhibitors |
EP2582668B1 (en) | 2010-06-16 | 2016-01-13 | Bristol-Myers Squibb Company | Carboline carboxamide compounds useful as kinase inhibitors |
US9079827B2 (en) | 2011-01-25 | 2015-07-14 | Mitsui Chemicals Agro, Inc. | Process for production of aromatic amide carboxylic acid derivative |
JP5859640B2 (ja) | 2011-05-17 | 2016-02-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトンチロシンキナーゼ阻害剤 |
WO2013156431A1 (en) | 2012-04-17 | 2013-10-24 | Syngenta Participations Ag | Pesticidally active pyridyl- and pyrimidyl- substituted thiazole and thiadiazole derivatives |
IN2012CH01573A (pt) | 2012-04-20 | 2015-07-10 | Advinus Therapeutics Ltd | |
WO2013157021A1 (en) | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
AR091273A1 (es) * | 2012-06-08 | 2015-01-21 | Biogen Idec Inc | Inhibidores de pirimidinil tirosina quinasa |
EP2858500A4 (en) | 2012-06-08 | 2016-04-06 | Biogen Ma Inc | INHIBITORS OF BRUTON TYROSINE KINASE |
EP3550031A1 (en) | 2012-07-24 | 2019-10-09 | Pharmacyclics, LLC | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
EP2892880B1 (en) * | 2012-09-07 | 2017-11-22 | Novartis AG | Indole carboxamide derivatives and uses thereof |
HUE031980T2 (en) | 2013-04-25 | 2017-08-28 | Beigene Ltd | Condensed heterocyclic compounds as protein kinase inhibitors |
EP3013815B1 (en) * | 2013-06-25 | 2017-05-03 | Bristol-Myers Squibb Company | Carbazole carboxamide compounds useful as kinase inhibitors |
UY35625A (es) * | 2013-06-25 | 2014-12-31 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa |
SG11201510503UA (en) * | 2013-06-26 | 2016-01-28 | Abbvie Inc | Primary carboxamides as btk inhibitors |
WO2015035606A1 (en) | 2013-09-13 | 2015-03-19 | Beigene, Ltd. | Anti-pd1 antibodies and their use as therapeutics and diagnostics |
US10662193B2 (en) | 2014-01-21 | 2020-05-26 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins |
WO2015173764A1 (en) | 2014-05-15 | 2015-11-19 | Iteos Therapeutics | Pyrrolidine-2,5-dione derivatives, pharmaceutical compositions and methods for use as ido1 inhibitors |
EP3160505A4 (en) | 2014-07-03 | 2018-01-24 | BeiGene, Ltd. | Anti-pd-l1 antibodies and their use as therapeutics and diagnostics |
EP3209665B1 (en) | 2014-10-22 | 2019-08-14 | Bristol-Myers Squibb Company | Substituted pyrrolotriazine amine compounds as pi3k inhibitors |
ES2807785T3 (es) | 2014-10-22 | 2021-02-24 | Bristol Myers Squibb Co | Compuestos de heteroarilamina bicíclicos como inhibidores de pi3k |
DK3209651T3 (da) * | 2014-10-24 | 2020-02-03 | Bristol Myers Squibb Co | Carbazolderivater |
TWI744218B (zh) | 2014-10-24 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 吲哚甲醯胺化合物 |
ES2800173T3 (es) * | 2014-10-24 | 2020-12-28 | Bristol Myers Squibb Co | Compuestos de atropisómeros tricíclicos |
JP6777637B2 (ja) * | 2014-12-30 | 2020-10-28 | ダウ アグロサイエンシィズ エルエルシー | 殺真菌剤としてのピコリンアミド |
EP3042903B1 (en) | 2015-01-06 | 2019-08-14 | Impetis Biosciences Ltd. | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof |
SG11201706992TA (en) | 2015-03-17 | 2017-09-28 | Pfizer | Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
KR102654709B1 (ko) * | 2015-03-18 | 2024-04-03 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 트리시클릭 헤테로시클릭 화합물 |
MA52119A (fr) | 2015-10-19 | 2018-08-29 | Ncyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
JP6931646B2 (ja) * | 2015-10-21 | 2021-09-08 | 大塚製薬株式会社 | ベンゾラクタム化合物 |
CN105272903B (zh) * | 2015-11-17 | 2018-07-10 | 江苏师范大学 | 系列含氟咔唑类化合物及其制备方法和应用 |
SG11201804152RA (en) | 2015-11-19 | 2018-06-28 | Incyte Corp | Heterocyclic compounds as immunomodulators |
JP2017101020A (ja) * | 2015-11-25 | 2017-06-08 | 宇部興産株式会社 | 高純度フェノール化合物の製造方法 |
MA55194A (fr) | 2015-12-22 | 2022-05-04 | Incyte Corp | Composés hétérocycliques en tant qu'immunomodulateurs |
EP3452476B1 (en) | 2016-05-06 | 2021-12-15 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
MA45116A (fr) | 2016-05-26 | 2021-06-02 | Incyte Corp | Composés hétérocycliques comme immunomodulateurs |
IL263825B (en) | 2016-06-20 | 2022-08-01 | Incyte Corp | Heterocyclic compounds as immunomodulators |
WO2018007885A1 (en) | 2016-07-05 | 2018-01-11 | Beigene, Ltd. | COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER |
ES2930092T3 (es) | 2016-07-14 | 2022-12-07 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
BR112019001158A2 (pt) | 2016-07-21 | 2019-04-30 | Biogen Ma, Inc. | formas de succinato e composições de inibidores da tirosina quinase de bruton |
NZ751418A (en) | 2016-08-16 | 2023-04-28 | Beigene Ltd | Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
CA3034326A1 (en) | 2016-08-19 | 2018-02-22 | Beigene, Ltd. | Use of a combination comprising a btk inhibitor for treating cancers |
US20180057486A1 (en) | 2016-08-29 | 2018-03-01 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
EP3515414B1 (en) | 2016-09-19 | 2022-11-30 | MEI Pharma, Inc. | Combination therapy |
CN111454248A (zh) * | 2016-12-01 | 2020-07-28 | 阿尔维纳斯运营股份有限公司 | 作为雌激素受体降解剂的四氢萘和四氢异喹啉衍生物 |
ES2833430T3 (es) * | 2016-12-20 | 2021-06-15 | Bristol Myers Squibb Co | Proceso para preparar un compuesto de tetrahidrocarbazol carboxamida |
MY197635A (en) | 2016-12-22 | 2023-06-29 | Incyte Corp | Benzooxazole derivatives as immunomodulators |
HRP20221216T1 (hr) | 2016-12-22 | 2022-12-23 | Incyte Corporation | Derivati tetrahidro imidazo[4,5-c]piridina kao induktori internalizacije pd-l1 |
ES2874756T3 (es) | 2016-12-22 | 2021-11-05 | Incyte Corp | Derivados de triazolo[1,5-A]piridina como inmunomoduladores |
ES2899402T3 (es) | 2016-12-22 | 2022-03-11 | Incyte Corp | Derivados de piridina como inmunomoduladores |
US11555038B2 (en) | 2017-01-25 | 2023-01-17 | Beigene, Ltd. | Crystalline forms of (S)-7-(1-(but-2-ynoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
GB201706327D0 (en) | 2017-04-20 | 2017-06-07 | Otsuka Pharma Co Ltd | A pharmaceutical compound |
KR20200020902A (ko) | 2017-06-26 | 2020-02-26 | 베이진 엘티디 | 간세포암(hepatocellular carcinoma: HCC)에 대한 면역 치료 |
WO2019034009A1 (en) | 2017-08-12 | 2019-02-21 | Beigene, Ltd. | BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY |
WO2019108795A1 (en) | 2017-11-29 | 2019-06-06 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors |
IL313101A (en) | 2018-03-30 | 2024-07-01 | Incyte Corp | Heterocyclic compounds as immunomodulators |
PT3790877T (pt) | 2018-05-11 | 2023-05-10 | Incyte Corp | Derivados de tetrahidro-imidazo[4,5-c]piridina como imunomoduladores pd-l1 |
WO2020030754A1 (en) | 2018-08-10 | 2020-02-13 | Syngenta Crop Protection Ag | Pesticidally-active mesoionic bicyclic heteroaromatic compounds |
WO2020035565A1 (en) | 2018-08-17 | 2020-02-20 | Syngenta Crop Protection Ag | Pesticidally-active mesoionic bicyclic heteroaromatic compounds |
TW202045011A (zh) | 2019-02-28 | 2020-12-16 | 瑞士商先正達農作物保護公司 | 具有含硫取代基之殺有害生物活性雜環衍生物 |
MX2022001671A (es) | 2019-08-09 | 2022-05-13 | Incyte Corp | Sales de un inhibidor de pd-1/pd-l1. |
BR112022005826A2 (pt) | 2019-09-30 | 2022-06-21 | Incyte Corp | Compostos de pirido[3,2-d]pirimidina como imunomoduladores |
BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
AR120982A1 (es) | 2020-01-06 | 2022-04-06 | Syngenta Crop Protection Ag | Derivados heterocíclicos activos como plaguicidas con sustituyentes que contienen azufre |
JP2023521172A (ja) * | 2020-04-10 | 2023-05-23 | ジービー005, インコーポレイテッド | キナーゼ阻害剤 |
WO2022013417A1 (en) | 2020-07-17 | 2022-01-20 | Syngenta Crop Protection Ag | Pesticidally active heterocyclic derivatives with sulfur containing substituents |
WO2022017975A1 (en) | 2020-07-18 | 2022-01-27 | Syngenta Crop Protection Ag | Pesticidally active heterocyclic derivatives with sulfur containing substituents |
WO2022043576A2 (en) | 2020-08-31 | 2022-03-03 | Syngenta Crop Protection Ag | Pesticidally active heterocyclic derivatives with sulfur containing substituents |
WO2022049141A1 (en) | 2020-09-01 | 2022-03-10 | Syngenta Crop Protection Ag | Pesticidally active heterocyclic derivatives with sulfur containing substituents |
JP2023540311A (ja) | 2020-09-02 | 2023-09-22 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に活性である硫黄含有置換基を有する複素環式誘導体 |
UY39402A (es) | 2020-09-02 | 2022-03-31 | Syngenta Crop Protection Ag | Derivados con actividad pesticida de 3-oxo-isoindolina-5-il o 5-oxo-7h-pirrolo [3,4-b]piridina-3-il con sustituyentes que contienen azufre |
MX2023004539A (es) * | 2020-10-21 | 2023-06-15 | Azura Ophthalmics Ltd | Compuestos y metodos para el tratamiento de trastornos oculares. |
WO2022099071A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof |
US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
AR126700A1 (es) | 2021-08-10 | 2023-11-01 | Syngenta Crop Protection Ag | Derivados heterocíclicos activos como plaguicidas con sustituyentes que contienen azufre |
WO2023187191A1 (en) | 2022-04-01 | 2023-10-05 | Syngenta Crop Protection Ag | Pesticidally active heterocyclic derivatives with sulfur containing substituents |
US11786531B1 (en) | 2022-06-08 | 2023-10-17 | Beigene Switzerland Gmbh | Methods of treating B-cell proliferative disorder |
WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
WO2024126650A1 (en) | 2022-12-15 | 2024-06-20 | Syngenta Crop Protection Ag | Novel bicyclic-carboxamide compounds useful as pesticides |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6000900A (en) | 1999-07-23 | 2001-02-13 | Astrazeneca Uk Limited | Carbazole derivatives and their use as neuropeptide y5 receptor ligands |
MXPA04003419A (es) | 2001-10-09 | 2004-07-08 | Upjohn Co | Tetrahidro y hexahidro-carbazoles sustituidos con arilsulfonilo como ligandos del receptor 5-ht-6. |
NZ542882A (en) | 2003-04-11 | 2007-10-26 | Glenmark Pharmaceuticals Sa | Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
US20060183746A1 (en) | 2003-06-04 | 2006-08-17 | Currie Kevin S | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
US7393848B2 (en) | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
US20050288295A1 (en) | 2003-11-11 | 2005-12-29 | Currie Kevin S | Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof |
JP2007536217A (ja) | 2004-04-06 | 2007-12-13 | ザ プロクター アンド ギャンブル カンパニー | ケラチン染色化合物、それらを含有するケラチン染色組成物、及びそれらの使用 |
PE20060748A1 (es) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
JP2008514611A (ja) | 2004-09-23 | 2008-05-08 | ワイス | C型肝炎ウイルスによる感染を処置するためのカルバゾールおよびシクロペンタインドールの誘導体 |
JP2008516973A (ja) | 2004-10-15 | 2008-05-22 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
BRPI0517619A (pt) | 2004-11-10 | 2008-10-14 | Cgi Pharmaceuticals Inc | entidades quìmicas de imidazo[1,2-a] pirazin-8-ilaminas, suas composições farmacêuticas, uso dos referidos compostos na preparação de medicamento, processo de preparação de medicamento e métodos de utilização dos referidos compostos |
US20060173183A1 (en) | 2004-12-31 | 2006-08-03 | Alantos Pharmaceuticals, Inc., | Multicyclic bis-amide MMP inhibitors |
KR101357524B1 (ko) | 2005-03-10 | 2014-02-03 | 질레드 코네티컷 인코포레이티드 | 특정 치환된 아미드, 그의 제조 방법, 및 사용 방법 |
US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
EA015463B1 (ru) | 2005-11-17 | 2011-08-30 | Оси Фармасьютикалз, Инк. | КОНДЕНСИРОВАННОЕ БИЦИКЛИЧЕСКОЕ СОЕДИНЕНИЕ - ИНГИБИТОР mTOR, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЕГО СОДЕРЖАЩАЯ, И СПОСОБ ЛЕЧЕНИЯ РАКА |
ES2390135T3 (es) | 2005-11-22 | 2012-11-06 | Merck Sharp & Dohme Corp. | Compuestos tricíclicos útiles como inhibidores de quinasas |
WO2008021851A2 (en) | 2006-08-09 | 2008-02-21 | Smithkline Beecham Corporation | Novel compounds as antagonists or inverse agonists for opioid receptors |
WO2008021745A2 (en) | 2006-08-16 | 2008-02-21 | Itherx Pharmaceuticals, Inc. | Hepatitis c virus entry inhibitors |
JP2010502751A (ja) | 2006-09-11 | 2010-01-28 | シージーアイ ファーマシューティカルズ,インコーポレイティド | キナーゼ阻害物質、およびキナーゼ阻害物質の使用および同定方法 |
EP2074106B1 (en) | 2006-09-11 | 2013-04-17 | Mylan Laboratories Limited | Dibenzofuran derivatives as inhibitors of pde-4 and pde-10 |
US7492329B2 (en) | 2006-10-12 | 2009-02-17 | Hewlett-Packard Development Company, L.P. | Composite material with chirped resonant cells |
CA2667644A1 (en) | 2006-10-27 | 2008-05-15 | Wyeth | Tricyclic compounds as matrix metalloproteinase inhibitors |
WO2008064318A2 (en) | 2006-11-22 | 2008-05-29 | University Of Medicine And Dentistry Of New Jersey | Peripheral opioid receptor active compounds |
WO2008064317A1 (en) | 2006-11-22 | 2008-05-29 | University Of Medicine And Dentistry Of New Jersey | Lipophilic opioid receptor active compounds |
ES2415863T3 (es) | 2006-12-22 | 2013-07-29 | Incyte Corporation | Heterociclos sustituidos como inhibidores de Janus Quinasas |
SE530889C2 (sv) | 2007-02-27 | 2008-10-07 | Scania Cv Abp | Bränsletankarrangemang för ett fordon |
DE102007056922A1 (de) | 2007-11-27 | 2009-05-28 | BSH Bosch und Siemens Hausgeräte GmbH | Wasserführendes Hausgerät mit einer Wasserweiche |
AU2008335761B2 (en) | 2007-12-13 | 2014-04-24 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
JP5381718B2 (ja) | 2008-01-31 | 2014-01-08 | コニカミノルタ株式会社 | ハロ多環芳香族化合物及びその製造方法 |
EP2095818A1 (en) | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Use of LHRH antagonists at non-castrating doses |
ES2490867T3 (es) | 2008-12-19 | 2014-09-04 | Bristol-Myers Squibb Company | Inhibidores de carbazol y carbolina quinasas |
SG171815A1 (en) * | 2008-12-19 | 2011-07-28 | Bristol Myers Squibb Co | Carbazole carboxamide compounds useful as kinase inhibitors |
-
2009
- 2009-12-17 SG SG2011037793A patent/SG171815A1/en unknown
- 2009-12-17 BR BRPI0922565A patent/BRPI0922565A2/pt not_active IP Right Cessation
- 2009-12-17 CA CA2747670A patent/CA2747670A1/en not_active Abandoned
- 2009-12-17 JP JP2011542421A patent/JP5487214B2/ja not_active Expired - Fee Related
- 2009-12-17 KR KR1020117016659A patent/KR20110098827A/ko not_active Application Discontinuation
- 2009-12-17 MX MX2011006171A patent/MX2011006171A/es active IP Right Grant
- 2009-12-17 EA EA201100992A patent/EA019041B1/ru not_active IP Right Cessation
- 2009-12-17 EP EP09793680.1A patent/EP2391602B1/en not_active Not-in-force
- 2009-12-17 WO PCT/US2009/068415 patent/WO2010080481A1/en active Application Filing
- 2009-12-17 US US12/640,119 patent/US8084620B2/en active Active
- 2009-12-17 NZ NZ593096A patent/NZ593096A/xx not_active IP Right Cessation
- 2009-12-17 ES ES09793680.1T patent/ES2443948T3/es active Active
- 2009-12-17 AU AU2009335821A patent/AU2009335821A1/en not_active Abandoned
- 2009-12-17 PE PE2011001234A patent/PE20110819A1/es not_active Application Discontinuation
- 2009-12-17 CN CN200980157181.6A patent/CN102325753B/zh not_active Expired - Fee Related
- 2009-12-18 AR ARP090104994A patent/AR074812A1/es not_active Application Discontinuation
- 2009-12-18 TW TW098143782A patent/TW201028401A/zh unknown
-
2011
- 2011-05-26 TN TN2011000274A patent/TN2011000274A1/fr unknown
- 2011-05-26 IL IL213185A patent/IL213185A0/en unknown
- 2011-06-15 ZA ZA2011/04469A patent/ZA201104469B/en unknown
- 2011-06-15 CO CO11074857A patent/CO6390055A2/es active IP Right Grant
- 2011-06-17 CL CL2011001516A patent/CL2011001516A1/es unknown
- 2011-11-09 US US13/292,153 patent/US8362065B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2747670A1 (en) | 2010-07-15 |
EP2391602A1 (en) | 2011-12-07 |
CN102325753A (zh) | 2012-01-18 |
AU2009335821A1 (en) | 2010-07-15 |
NZ593096A (en) | 2012-11-30 |
CO6390055A2 (es) | 2012-02-29 |
IL213185A0 (en) | 2011-07-31 |
JP2012512888A (ja) | 2012-06-07 |
TW201028401A (en) | 2010-08-01 |
US20120058996A1 (en) | 2012-03-08 |
EA019041B1 (ru) | 2013-12-30 |
ES2443948T3 (es) | 2014-02-21 |
KR20110098827A (ko) | 2011-09-01 |
JP5487214B2 (ja) | 2014-05-07 |
ZA201104469B (en) | 2012-11-28 |
SG171815A1 (en) | 2011-07-28 |
US20100160303A1 (en) | 2010-06-24 |
MX2011006171A (es) | 2011-06-20 |
WO2010080481A1 (en) | 2010-07-15 |
US8362065B2 (en) | 2013-01-29 |
CL2011001516A1 (es) | 2012-01-20 |
EA201100992A1 (ru) | 2011-12-30 |
PE20110819A1 (es) | 2011-11-02 |
TN2011000274A1 (en) | 2012-12-17 |
CN102325753B (zh) | 2014-09-10 |
AR074812A1 (es) | 2011-02-16 |
EP2391602B1 (en) | 2013-12-04 |
US8084620B2 (en) | 2011-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0922565A2 (pt) | compostos de carbazol carboxamida úteis como inibidores de cinase | |
CY2019027I1 (el) | Παραγωγα φωσφορου ως αναστολεις κινασης | |
BRPI0920135A2 (pt) | imidazopiridazinacarbonitrilos úteis como inibidores de quinase | |
BRPI0811065A2 (pt) | Indazóis 5-heteroaril substituídos como inibidores de quinase | |
BRPI0913879A2 (pt) | fenilpirazinonas como inibidores de quinase | |
BRPI0918846A2 (pt) | inibidores de cinase heterocíclica | |
BRPI0908494A2 (pt) | Inibidores de pirrolopirazina quinase | |
ATE519763T1 (de) | Pyrrolopyrazin-kinasehemmer | |
BRPI0912475A2 (pt) | compostos como inibidores de quinase | |
BRPI0918045A2 (pt) | compostos de carboxamida heterocíclicos | |
BRPI0914652A2 (pt) | compostos e composições como inibidores de quinase | |
EP2346508A4 (en) | HETEROCYCLIC INHIBITORS OF KINASES | |
BRPI0920239A2 (pt) | compostos heterocíclicos como inibidores de proteínas quinases | |
BRPI0922880A2 (pt) | compostos inibidores de quinase | |
BRPI0906838A2 (pt) | Pirimidinas como inibidores de quinase | |
BRPI0906705A2 (pt) | Composto heterocíclicos | |
BRPI0910979A2 (pt) | compostos e composições como inibidores de quinase | |
BRPI0914305A2 (pt) | Compostos de piridazina carboxamida substituída como compostos inibidores da quinase | |
BRPI0914545A2 (pt) | compostos e composições como inibidores de quinase | |
BR112012018830A2 (pt) | compostos heterocíclicos como inibidores de quinase de janus | |
EP2231152A4 (en) | THIENOPYRANONES AS KINASE INHIBITORS | |
HK1156611A1 (en) | Naphthyridininones as aurora kinase inhibitors aurora | |
EP2611806A4 (en) | HETEROCYCLIC COMPOUNDS ENRICHED IN DEUTERIUM AS INHIBITORS OF KINASES | |
NO20083270L (no) | Indolforbindelser | |
TH0901000740A (th) | สารประกอบอินทรีย์ที่เป็นสารยับยั้ง scd-1 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |