BR112012018830A2 - compostos heterocíclicos como inibidores de quinase de janus - Google Patents
compostos heterocíclicos como inibidores de quinase de janusInfo
- Publication number
- BR112012018830A2 BR112012018830A2 BR112012018830A BR112012018830A BR112012018830A2 BR 112012018830 A2 BR112012018830 A2 BR 112012018830A2 BR 112012018830 A BR112012018830 A BR 112012018830A BR 112012018830 A BR112012018830 A BR 112012018830A BR 112012018830 A2 BR112012018830 A2 BR 112012018830A2
- Authority
- BR
- Brazil
- Prior art keywords
- kinase inhibitors
- heterocyclic compounds
- janus kinase
- janus
- heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28997809P | 2009-12-23 | 2009-12-23 | |
| US28997509P | 2009-12-23 | 2009-12-23 | |
| PCT/US2010/061912 WO2011079230A2 (en) | 2009-12-23 | 2010-12-22 | Heterocyclic compounds as janus kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012018830A2 true BR112012018830A2 (pt) | 2016-04-12 |
Family
ID=43532636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012018830A BR112012018830A2 (pt) | 2009-12-23 | 2010-12-22 | compostos heterocíclicos como inibidores de quinase de janus |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20120309773A1 (pt) |
| EP (1) | EP2516444A2 (pt) |
| JP (1) | JP2013515740A (pt) |
| KR (1) | KR20120101721A (pt) |
| CN (1) | CN102762571A (pt) |
| AR (1) | AR079705A1 (pt) |
| AU (1) | AU2010336437A1 (pt) |
| BR (1) | BR112012018830A2 (pt) |
| CA (1) | CA2783475A1 (pt) |
| IL (1) | IL220205A0 (pt) |
| RU (1) | RU2012130929A (pt) |
| TW (1) | TW201132644A (pt) |
| WO (1) | WO2011079230A2 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2813437A1 (en) | 2010-10-08 | 2012-04-12 | Abbvie Inc. | Furo[3,2-d]pyrimidine compounds |
| JP6077642B2 (ja) | 2012-04-10 | 2017-02-08 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | 縮合ピリミジン化合物、その調製法、中間体、組成物、及び使用 |
| CN103012428A (zh) | 2013-01-08 | 2013-04-03 | 中国药科大学 | 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途 |
| EP2947084B8 (en) * | 2013-01-18 | 2021-03-10 | Guangzhou Maxinovel Pharmaceuticals Co. | Five-and-six-membered heterocyclic compound, and preparation method, pharmaceutical composition and use thereof |
| US9745321B2 (en) | 2013-09-30 | 2017-08-29 | Shanghai Yingli Pharmaceutical Co., Ltd | Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof |
| CR20160493A (es) | 2014-04-25 | 2016-12-16 | Pfizer | Compuestos heteroaromáticos y su uso como ligandos de dopamina d1 |
| CN111108109A (zh) | 2017-09-20 | 2020-05-05 | 利奥制药有限公司 | 取代的二氢噻吩并嘧啶及其作为磷酸二酯酶抑制剂的用途 |
| JP7203846B2 (ja) | 2017-12-15 | 2023-01-13 | ユニオン・セラピューティクス・アクティエセルスカブ | 置換アゼチジンジヒドロチエノピリジンおよびホスホジエステラーゼ阻害剤としてのそれらの使用 |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| WO2020175968A1 (ko) * | 2019-02-28 | 2020-09-03 | 주식회사 보로노이 | N을 포함하는 헤테로아릴 유도체 및 이를 유효성분으로 포함하는 약학적 조성물 |
| CN117700428A (zh) * | 2022-09-08 | 2024-03-15 | 广州再极医药科技有限公司 | 一种五元并六元杂环化合物的晶型及其制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3143876A1 (de) | 1981-11-05 | 1983-05-11 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue1-furyl-3,4-dihydroisochinoline diese enthaltende arzneimittel sowie verfahren zu deren herstellung und deren verwendung |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| ES2305435T3 (es) * | 2002-01-10 | 2008-11-01 | Bayer Healthcare Ag | Inhibidores de la rho-quinasa. |
| CN101166750A (zh) | 2004-10-29 | 2008-04-23 | 拜奥克里斯特制药公司 | 治疗用呋喃并嘧啶类化合物和噻吩并嘧啶类化合物 |
| CN101293909B (zh) | 2007-04-27 | 2012-05-30 | 中国科学院化学研究所 | 具有电位势梯度的核酸仿生纳米材料及其制备方法和用途 |
| CN101072340B (zh) | 2007-06-25 | 2012-07-18 | 孟智平 | 流媒体中加入广告信息的方法与系统 |
| EP2020412A1 (en) | 2007-07-30 | 2009-02-04 | Cellzome Limited | Sulphur containing amino pyrimidine compounds for the treatment of inflammatory disorders |
| CN102014627B (zh) * | 2008-04-30 | 2014-10-29 | 国家卫生研究院 | 作为极光激酶抑制剂的稠合双环嘧啶化合物 |
| CN101475493B (zh) | 2009-02-11 | 2013-01-23 | 中国科学技术大学 | 有机阴阳离子对的制备方法 |
-
2010
- 2010-12-22 JP JP2012546214A patent/JP2013515740A/ja not_active Withdrawn
- 2010-12-22 TW TW099145368A patent/TW201132644A/zh unknown
- 2010-12-22 CN CN2010800645783A patent/CN102762571A/zh active Pending
- 2010-12-22 EP EP10798934A patent/EP2516444A2/en not_active Withdrawn
- 2010-12-22 WO PCT/US2010/061912 patent/WO2011079230A2/en active Application Filing
- 2010-12-22 BR BR112012018830A patent/BR112012018830A2/pt not_active Application Discontinuation
- 2010-12-22 KR KR1020127019474A patent/KR20120101721A/ko not_active Application Discontinuation
- 2010-12-22 AU AU2010336437A patent/AU2010336437A1/en not_active Abandoned
- 2010-12-22 CA CA2783475A patent/CA2783475A1/en not_active Abandoned
- 2010-12-22 AR ARP100104890A patent/AR079705A1/es not_active Application Discontinuation
- 2010-12-22 RU RU2012130929/04A patent/RU2012130929A/ru unknown
- 2010-12-22 US US13/519,015 patent/US20120309773A1/en not_active Abandoned
-
2012
- 2012-06-06 IL IL220205A patent/IL220205A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR079705A1 (es) | 2012-02-15 |
| CN102762571A (zh) | 2012-10-31 |
| AU2010336437A1 (en) | 2012-07-19 |
| KR20120101721A (ko) | 2012-09-14 |
| WO2011079230A2 (en) | 2011-06-30 |
| WO2011079230A3 (en) | 2011-10-20 |
| US20120309773A1 (en) | 2012-12-06 |
| RU2012130929A (ru) | 2014-01-27 |
| EP2516444A2 (en) | 2012-10-31 |
| TW201132644A (en) | 2011-10-01 |
| JP2013515740A (ja) | 2013-05-09 |
| CA2783475A1 (en) | 2011-06-30 |
| IL220205A0 (en) | 2012-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |