BRPI1009800A2 - compostos heterocíclicos como inibidores de autotaxina - Google Patents
compostos heterocíclicos como inibidores de autotaxinaInfo
- Publication number
- BRPI1009800A2 BRPI1009800A2 BRPI1009800A BRPI1009800A BRPI1009800A2 BR PI1009800 A2 BRPI1009800 A2 BR PI1009800A2 BR PI1009800 A BRPI1009800 A BR PI1009800A BR PI1009800 A BRPI1009800 A BR PI1009800A BR PI1009800 A2 BRPI1009800 A2 BR PI1009800A2
- Authority
- BR
- Brazil
- Prior art keywords
- heterocyclic compounds
- autotaxin inhibitors
- autotaxin
- inhibitors
- heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09004858 | 2009-04-02 | ||
| PCT/EP2010/001324 WO2010112116A1 (de) | 2009-04-02 | 2010-03-03 | Heterocyclische verbindungen als autotaxin-inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1009800A2 true BRPI1009800A2 (pt) | 2016-03-15 |
Family
ID=42102768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1009800A BRPI1009800A2 (pt) | 2009-04-02 | 2010-03-03 | compostos heterocíclicos como inibidores de autotaxina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8841324B2 (pt) |
| EP (1) | EP2414327B1 (pt) |
| JP (1) | JP5767205B2 (pt) |
| KR (1) | KR20120027192A (pt) |
| CN (1) | CN102365271B (pt) |
| AR (1) | AR076006A1 (pt) |
| AU (1) | AU2010230646B2 (pt) |
| BR (1) | BRPI1009800A2 (pt) |
| CA (1) | CA2757413C (pt) |
| EA (1) | EA201101399A1 (pt) |
| ES (1) | ES2527788T3 (pt) |
| IL (1) | IL215258A0 (pt) |
| MX (1) | MX2011010207A (pt) |
| SG (1) | SG174520A1 (pt) |
| WO (1) | WO2010112116A1 (pt) |
| ZA (1) | ZA201107986B (pt) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2775000T3 (es) * | 2009-04-02 | 2020-07-23 | Merck Patent Gmbh | Derivados de piperidina y piperazina como inhibidores de autotaxina |
| EA201492223A1 (ru) | 2012-06-13 | 2015-03-31 | Ф. Хоффманн-Ля Рош Аг | Новые диазаспироциклоалканы и азаспироциклоалканы |
| CN104684915B (zh) * | 2012-09-25 | 2017-10-31 | 霍夫曼-拉罗奇有限公司 | 新型双环衍生物 |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| US20140171404A1 (en) * | 2012-12-19 | 2014-06-19 | Novartis Ag | Autotaxin inhibitors |
| AR095079A1 (es) * | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| WO2015008230A1 (en) | 2013-07-18 | 2015-01-22 | Novartis Ag | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core |
| WO2015008229A1 (en) * | 2013-07-18 | 2015-01-22 | Novartis Ag | Autotaxin inhibitors |
| EP3046905A4 (en) | 2013-09-17 | 2017-03-22 | Pharmakea Inc. | Vinyl autotaxin inhibitor compounds |
| WO2015042052A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| US9850203B2 (en) | 2013-09-26 | 2017-12-26 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| PL3071561T3 (pl) * | 2013-11-22 | 2021-11-08 | Sabre Therapeutics Llc | Związki inhibitora autotaksyny |
| CN105764903B (zh) | 2013-11-22 | 2018-09-18 | 法玛克亚公司 | 四环自分泌运动因子抑制剂 |
| PE20160845A1 (es) | 2013-11-26 | 2016-09-10 | Hoffmann La Roche | Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo |
| JP6554481B2 (ja) | 2014-03-26 | 2019-07-31 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物 |
| DK3122750T3 (da) | 2014-03-26 | 2019-11-04 | Hoffmann La Roche | Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere |
| AU2015240519B2 (en) | 2014-04-04 | 2019-08-15 | X-Rx, Inc. | Substituted spirocyclic inhibitors of autotaxin |
| US20170037030A1 (en) | 2014-04-24 | 2017-02-09 | Novartis Ag | Autotaxin inhibitors |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| KR20170103960A (ko) * | 2015-01-20 | 2017-09-13 | 노파르티스 아게 | Pet 영상화제 |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| US10632104B2 (en) | 2015-05-27 | 2020-04-28 | Sabre Therapeutics Llc | Autotaxin inhibitors and uses thereof |
| EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| KR20180043837A (ko) | 2015-09-04 | 2018-04-30 | 에프. 호프만-라 로슈 아게 | 페녹시메틸 유도체 |
| CR20180057A (es) | 2015-09-24 | 2018-04-02 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca. |
| RU2018114289A (ru) | 2015-09-24 | 2019-10-24 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов аутотаксина (atx) |
| KR20180053408A (ko) | 2015-09-24 | 2018-05-21 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물 |
| CN107922412B (zh) | 2015-09-24 | 2021-02-23 | 豪夫迈·罗氏有限公司 | 作为atx抑制剂的二环化合物 |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| WO2018167001A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual atx/ca inhibitors |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
| KR101966286B1 (ko) | 2018-01-26 | 2019-04-05 | 조재석 | 소변의 비산 방지용 양변기 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| DE10050236A1 (de) * | 2000-10-11 | 2002-04-25 | Merck Patent Gmbh | Verwendung bestimmter Substanzen, die an den Sigma-Rezeptor binden, zur Behandlung von Sarkomen und Karzinomen |
| AU2002338334B8 (en) | 2001-04-03 | 2008-09-18 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists |
| DE10210779A1 (de) * | 2002-03-12 | 2003-10-09 | Merck Patent Gmbh | Cyclische Amide |
| US7205303B2 (en) * | 2003-01-03 | 2007-04-17 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds |
| DE102007047737A1 (de) * | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
-
2010
- 2010-03-03 BR BRPI1009800A patent/BRPI1009800A2/pt not_active Application Discontinuation
- 2010-03-03 US US13/259,464 patent/US8841324B2/en not_active Expired - Fee Related
- 2010-03-03 KR KR1020117025897A patent/KR20120027192A/ko not_active Application Discontinuation
- 2010-03-03 EA EA201101399A patent/EA201101399A1/xx unknown
- 2010-03-03 ES ES10706554.2T patent/ES2527788T3/es active Active
- 2010-03-03 WO PCT/EP2010/001324 patent/WO2010112116A1/de active Application Filing
- 2010-03-03 CN CN201080014895.4A patent/CN102365271B/zh not_active Expired - Fee Related
- 2010-03-03 MX MX2011010207A patent/MX2011010207A/es not_active Application Discontinuation
- 2010-03-03 JP JP2012502478A patent/JP5767205B2/ja not_active Expired - Fee Related
- 2010-03-03 AU AU2010230646A patent/AU2010230646B2/en not_active Ceased
- 2010-03-03 CA CA2757413A patent/CA2757413C/en not_active Expired - Fee Related
- 2010-03-03 SG SG2011068640A patent/SG174520A1/en unknown
- 2010-03-03 EP EP10706554.2A patent/EP2414327B1/de not_active Not-in-force
- 2010-03-31 AR ARP100101048A patent/AR076006A1/es unknown
-
2011
- 2011-09-20 IL IL215258A patent/IL215258A0/en active IP Right Grant
- 2011-11-01 ZA ZA2011/07986A patent/ZA201107986B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010230646B2 (en) | 2015-11-26 |
| CA2757413C (en) | 2017-01-10 |
| SG174520A1 (en) | 2011-10-28 |
| US8841324B2 (en) | 2014-09-23 |
| CN102365271B (zh) | 2014-05-14 |
| EP2414327A1 (de) | 2012-02-08 |
| AR076006A1 (es) | 2011-05-11 |
| MX2011010207A (es) | 2011-10-14 |
| KR20120027192A (ko) | 2012-03-21 |
| IL215258A0 (en) | 2011-12-29 |
| WO2010112116A1 (de) | 2010-10-07 |
| EA201101399A1 (ru) | 2012-08-30 |
| EP2414327B1 (de) | 2014-11-19 |
| CN102365271A (zh) | 2012-02-29 |
| ES2527788T3 (es) | 2015-01-30 |
| JP5767205B2 (ja) | 2015-08-19 |
| ZA201107986B (en) | 2012-07-25 |
| CA2757413A1 (en) | 2010-10-07 |
| JP2012522733A (ja) | 2012-09-27 |
| US20120015959A1 (en) | 2012-01-19 |
| AU2010230646A1 (en) | 2011-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |