EA201101399A1 - Гетероциклические соединения в качестве ингибиторов аутотаксина - Google Patents
Гетероциклические соединения в качестве ингибиторов аутотаксинаInfo
- Publication number
- EA201101399A1 EA201101399A1 EA201101399A EA201101399A EA201101399A1 EA 201101399 A1 EA201101399 A1 EA 201101399A1 EA 201101399 A EA201101399 A EA 201101399A EA 201101399 A EA201101399 A EA 201101399A EA 201101399 A1 EA201101399 A1 EA 201101399A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- heterocyclic compounds
- autotaxin inhibitors
- autotaxin
- inhibitors
- sup
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09004858 | 2009-04-02 | ||
| PCT/EP2010/001324 WO2010112116A1 (de) | 2009-04-02 | 2010-03-03 | Heterocyclische verbindungen als autotaxin-inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201101399A1 true EA201101399A1 (ru) | 2012-08-30 |
Family
ID=42102768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201101399A EA201101399A1 (ru) | 2009-04-02 | 2010-03-03 | Гетероциклические соединения в качестве ингибиторов аутотаксина |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8841324B2 (xx) |
| EP (1) | EP2414327B1 (xx) |
| JP (1) | JP5767205B2 (xx) |
| KR (1) | KR20120027192A (xx) |
| CN (1) | CN102365271B (xx) |
| AR (1) | AR076006A1 (xx) |
| AU (1) | AU2010230646B2 (xx) |
| BR (1) | BRPI1009800A2 (xx) |
| CA (1) | CA2757413C (xx) |
| EA (1) | EA201101399A1 (xx) |
| ES (1) | ES2527788T3 (xx) |
| IL (1) | IL215258A0 (xx) |
| MX (1) | MX2011010207A (xx) |
| SG (1) | SG174520A1 (xx) |
| WO (1) | WO2010112116A1 (xx) |
| ZA (1) | ZA201107986B (xx) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2757368C (en) * | 2009-04-02 | 2019-03-12 | Merck Patent Gmbh | Piperidine and piperazine derivatives as autotaxin inhibitors |
| WO2013186159A1 (en) | 2012-06-13 | 2013-12-19 | F. Hoffmann-La Roche Ag | New diazaspirocycloalkane and azaspirocycloalkane |
| IN2015DN00960A (xx) * | 2012-09-25 | 2015-06-12 | Hoffmann La Roche | |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| JP6363616B2 (ja) * | 2012-12-19 | 2018-07-25 | ノバルティス アーゲー | オートタキシン阻害剤 |
| AR095079A1 (es) * | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| EP3022202B1 (en) | 2013-07-18 | 2019-05-15 | Novartis AG | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core |
| WO2015008229A1 (en) * | 2013-07-18 | 2015-01-22 | Novartis Ag | Autotaxin inhibitors |
| WO2015042053A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| EP3046909A4 (en) | 2013-09-17 | 2017-03-29 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| EP3049405A4 (en) | 2013-09-26 | 2017-03-08 | Pharmakea Inc. | Autotaxin inhibitor compounds |
| EP3071569A4 (en) | 2013-11-22 | 2017-09-13 | Pharmakea, Inc. | Tetracyclic autotaxin inhibitors |
| CA2930737C (en) * | 2013-11-22 | 2023-02-21 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| PL3074400T3 (pl) | 2013-11-26 | 2018-03-30 | F.Hoffmann-La Roche Ag | Pochodne oktahydrocyklobuta[1,2-c;3,4-c']dipirolu jako inhibitory autotaksyny |
| UA119347C2 (uk) | 2014-03-26 | 2019-06-10 | Ф. Хоффманн-Ля Рош Аг | Конденсовані [1,4]діазепінові сполуки як інгібітори продукції аутотаксину (atх) та лізофосфатидилової кислоти (lpa) |
| MA50635A (fr) | 2014-03-26 | 2020-08-12 | Hoffmann La Roche | Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique |
| WO2015154023A1 (en) | 2014-04-04 | 2015-10-08 | X-Rx Discovery, Inc. | Substituted spirocydic inhibitors of autotaxin |
| EP3134398A1 (en) | 2014-04-24 | 2017-03-01 | Novartis Ag | Autotaxin inhibitors |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| ES2828715T3 (es) | 2015-01-20 | 2021-05-27 | Novartis Ag | Agentes de formación de imágenes por PET |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| EA036337B1 (ru) | 2015-05-27 | 2020-10-28 | Сабре Терапьютикс Ллс | Ингибиторы аутотаксина и их применения |
| WO2016197009A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| PE20180479A1 (es) | 2015-09-04 | 2018-03-07 | Hoffmann La Roche | Nuevos derivados de fenoximetilo |
| CA2991615A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| RU2724899C2 (ru) | 2015-09-24 | 2020-06-26 | Ф. Хоффманн-Ля Рош Аг | Новые бициклические соединения в качестве дуальных ингибиторов atx/ca |
| CA2983782A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| CA2984585A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| CN110392679B (zh) | 2017-03-16 | 2023-04-07 | 豪夫迈·罗氏有限公司 | 可用作双重atx/ca抑制剂的杂环化合物 |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
| US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| KR101966286B1 (ko) | 2018-01-26 | 2019-04-05 | 조재석 | 소변의 비산 방지용 양변기 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| DE10050236A1 (de) * | 2000-10-11 | 2002-04-25 | Merck Patent Gmbh | Verwendung bestimmter Substanzen, die an den Sigma-Rezeptor binden, zur Behandlung von Sarkomen und Karzinomen |
| WO2002080928A1 (en) * | 2001-04-03 | 2002-10-17 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| DE10210779A1 (de) * | 2002-03-12 | 2003-10-09 | Merck Patent Gmbh | Cyclische Amide |
| EP1578737B1 (en) * | 2003-01-03 | 2009-09-16 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds |
| DE102007047737A1 (de) * | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
-
2010
- 2010-03-03 EP EP10706554.2A patent/EP2414327B1/de not_active Not-in-force
- 2010-03-03 KR KR1020117025897A patent/KR20120027192A/ko not_active Application Discontinuation
- 2010-03-03 WO PCT/EP2010/001324 patent/WO2010112116A1/de active Application Filing
- 2010-03-03 JP JP2012502478A patent/JP5767205B2/ja not_active Expired - Fee Related
- 2010-03-03 CA CA2757413A patent/CA2757413C/en not_active Expired - Fee Related
- 2010-03-03 ES ES10706554.2T patent/ES2527788T3/es active Active
- 2010-03-03 US US13/259,464 patent/US8841324B2/en not_active Expired - Fee Related
- 2010-03-03 BR BRPI1009800A patent/BRPI1009800A2/pt not_active Application Discontinuation
- 2010-03-03 EA EA201101399A patent/EA201101399A1/xx unknown
- 2010-03-03 MX MX2011010207A patent/MX2011010207A/es not_active Application Discontinuation
- 2010-03-03 SG SG2011068640A patent/SG174520A1/en unknown
- 2010-03-03 AU AU2010230646A patent/AU2010230646B2/en not_active Ceased
- 2010-03-03 CN CN201080014895.4A patent/CN102365271B/zh not_active Expired - Fee Related
- 2010-03-31 AR ARP100101048A patent/AR076006A1/es unknown
-
2011
- 2011-09-20 IL IL215258A patent/IL215258A0/en active IP Right Grant
- 2011-11-01 ZA ZA2011/07986A patent/ZA201107986B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120015959A1 (en) | 2012-01-19 |
| ZA201107986B (en) | 2012-07-25 |
| US8841324B2 (en) | 2014-09-23 |
| AU2010230646B2 (en) | 2015-11-26 |
| AU2010230646A1 (en) | 2011-11-17 |
| JP5767205B2 (ja) | 2015-08-19 |
| MX2011010207A (es) | 2011-10-14 |
| KR20120027192A (ko) | 2012-03-21 |
| CN102365271B (zh) | 2014-05-14 |
| SG174520A1 (en) | 2011-10-28 |
| JP2012522733A (ja) | 2012-09-27 |
| CN102365271A (zh) | 2012-02-29 |
| ES2527788T3 (es) | 2015-01-30 |
| CA2757413C (en) | 2017-01-10 |
| IL215258A0 (en) | 2011-12-29 |
| WO2010112116A1 (de) | 2010-10-07 |
| EP2414327A1 (de) | 2012-02-08 |
| AR076006A1 (es) | 2011-05-11 |
| BRPI1009800A2 (pt) | 2016-03-15 |
| CA2757413A1 (en) | 2010-10-07 |
| EP2414327B1 (de) | 2014-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201101399A1 (ru) | Гетероциклические соединения в качестве ингибиторов аутотаксина | |
| EA201200119A1 (ru) | Гетероциклические соединения в качестве ингибиторов аутотаксина | |
| EA201100880A1 (ru) | Бензонафтиридиновые соединения в качестве ингибиторов аутотаксина | |
| EA201200653A1 (ru) | Гетариламинохинолины | |
| EA201100125A1 (ru) | Производные пирролопиридинилпиримидин-2-иламина | |
| EA201300873A1 (ru) | Производные 7-азаиндола | |
| EA201000558A1 (ru) | Производные имидазола | |
| EA201000004A1 (ru) | Производные 6-(пирролопиридинил)пиримидин-2-иламина и их применение для лечения злокачественного новообразования и спида | |
| EA201000549A1 (ru) | Производные пиперидина и пиперазина | |
| EA201201170A1 (ru) | Гетариламинонафтиридины | |
| EA201300282A1 (ru) | Производные триазолопиразина | |
| EA201101585A1 (ru) | 3-(1,2,3-триазол-4-ил)пирроло[2,3-b]пиридинпроизводные | |
| EA201000094A1 (ru) | Производные пиримидинил-пиридазинона | |
| EA201400333A1 (ru) | Бензонитрильные производные в качестве ингибиторов киназ | |
| EA201001005A1 (ru) | Производные 2-бензилпиридазинона в качестве ингибиторов мет киназы | |
| EA201100966A1 (ru) | Производные пиридазинона | |
| EA201001359A1 (ru) | Гетероциклические соединения в качестве ингибиторов cxcr2 | |
| EA200901611A1 (ru) | Производные 2-оксо-3-бензил-бензоксазол-2-она и родственные соединения в качестве ингибиторов мет киназы для лечения опухолей | |
| EA201171210A1 (ru) | Производные оксадиазола | |
| EA201401081A1 (ru) | Циклические амиды в качестве ингибиторов метар-2 | |
| EA200901601A1 (ru) | Производные пиридазинона | |
| EA201300442A1 (ru) | ПИРРОЛИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ MetAP-2 | |
| EA201201081A1 (ru) | Производные гетарил[1,8]нафтиридина | |
| EA201000550A1 (ru) | Производные тиазола | |
| EA201001358A1 (ru) | Активаторы глюкокиназы |