EA201300442A1 - ПИРРОЛИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ MetAP-2 - Google Patents
ПИРРОЛИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ MetAP-2Info
- Publication number
- EA201300442A1 EA201300442A1 EA201300442A EA201300442A EA201300442A1 EA 201300442 A1 EA201300442 A1 EA 201300442A1 EA 201300442 A EA201300442 A EA 201300442A EA 201300442 A EA201300442 A EA 201300442A EA 201300442 A1 EA201300442 A1 EA 201300442A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitors
- metap
- pyrrolidinones
- compounds
- formula
- Prior art date
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A61K31/4245—Oxadiazoles
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Abstract
Соединения формулы Iв которой R, R, Rи Rимеют значения, указанные в п.1 формулы изобретения, являются ингибиторами метионинаминопептидазы и могут применяться для лечения опухолей.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102010048374A DE102010048374A1 (de) | 2010-10-13 | 2010-10-13 | Pyrrolidinone als MetAP-2 Inhibitoren |
PCT/EP2011/004608 WO2012048775A1 (de) | 2010-10-13 | 2011-09-14 | Pyrrolidinone als metap-2 inhibitoren |
Publications (2)
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EA201300442A1 true EA201300442A1 (ru) | 2013-11-29 |
EA022299B1 EA022299B1 (ru) | 2015-12-30 |
Family
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EA201300442A EA022299B1 (ru) | 2010-10-13 | 2011-09-14 | ПИРРОЛИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ MetAP-2 |
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EP (1) | EP2627631B1 (ru) |
JP (1) | JP5931885B2 (ru) |
KR (1) | KR101803126B1 (ru) |
CN (1) | CN103153951B (ru) |
AR (1) | AR083402A1 (ru) |
AU (1) | AU2011316199B2 (ru) |
BR (1) | BR112013008886B1 (ru) |
CA (1) | CA2814369C (ru) |
CY (1) | CY1117287T1 (ru) |
DE (1) | DE102010048374A1 (ru) |
DK (1) | DK2627631T3 (ru) |
EA (1) | EA022299B1 (ru) |
ES (1) | ES2563317T3 (ru) |
HK (1) | HK1186179A1 (ru) |
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HU (1) | HUE027149T2 (ru) |
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PL (1) | PL2627631T3 (ru) |
RS (1) | RS54629B1 (ru) |
SG (1) | SG189853A1 (ru) |
SI (1) | SI2627631T1 (ru) |
WO (1) | WO2012048775A1 (ru) |
Cited By (1)
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RU2694624C2 (ru) * | 2014-08-04 | 2019-07-17 | Мерк Патент Гмбх | Производные пирролидинона в качестве ингибиторов метар-2 |
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JP6042060B2 (ja) * | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
PT2573073E (pt) * | 2011-09-26 | 2015-02-05 | Sanofi Sa | Derivados de pirazoloquinolinona, sua preparação e sua utilização terapêutica |
DE102012006884A1 (de) | 2012-04-04 | 2013-10-10 | Merck Patent Gmbh | Cyclische Amide als MetAP-2 Inhibitoren |
JPWO2015037716A1 (ja) * | 2013-09-12 | 2017-03-02 | 住友化学株式会社 | 含窒素飽和複素環化合物 |
WO2017004797A1 (en) * | 2015-07-08 | 2017-01-12 | Eli Lilly And Company | Pyrrolidinone compounds |
WO2017084096A1 (en) * | 2015-11-20 | 2017-05-26 | Eli Lilly And Company | Pyrrolidinone compounds |
BR112018076812A2 (pt) * | 2016-06-21 | 2021-09-28 | The University Of Melbourne | Ativadores da latência de hiv |
WO2018098781A1 (en) * | 2016-12-01 | 2018-06-07 | Eli Lilly And Company | Pyrrolidinone compounds |
JP7169592B2 (ja) * | 2017-09-27 | 2022-11-11 | 国立大学法人 鹿児島大学 | Pac1受容体拮抗薬を用いた鎮痛薬 |
CN108409630B (zh) * | 2018-02-07 | 2021-01-15 | 宁波大学 | 一种水相中3-羟基-2-吲哚酮衍生物的制备方法 |
US20220062258A1 (en) | 2019-01-22 | 2022-03-03 | Merck Patent Gmbh | Heterocyclic derivatives |
FI3994134T3 (fi) | 2019-07-03 | 2024-04-24 | Merck Patent Gmbh | Menetelmä (S)-3-hydroksi-1-(1H-indol-5-yyli)-2-oksopyrrolidini-3-karboksyylihappo 3,5-difluori-bentsyyliamidin valmistamiseksi |
CN112480100B (zh) * | 2019-09-11 | 2022-10-14 | 康威(广州)生物科技有限公司 | 吡咯烷酮衍生物 |
CN110759843A (zh) * | 2019-09-30 | 2020-02-07 | 东北师范大学 | 一种氟叠氮取代的四元杂环化合物的制备和应用 |
EP4178572A1 (en) | 2020-07-09 | 2023-05-17 | Merck Patent GmbH | Combination of a methionine aminopeptidase 2 inhibitor and vegfr/vegf inhibitor |
CN112851561A (zh) * | 2021-01-29 | 2021-05-28 | 南京艾美斐生物医药科技有限公司 | 一种nr6a1蛋白受体抑制剂及其制备和应用 |
AU2022252615A1 (en) * | 2021-03-28 | 2023-10-12 | Canwell Biotech Limited | Metap-2 inhibitors, pharmaceutical compositions and therapeutic methods thereof |
WO2023144053A1 (en) | 2022-01-26 | 2023-08-03 | Merck Patent Gmbh | Heterocyclic derivatives |
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RU2694624C2 (ru) * | 2014-08-04 | 2019-07-17 | Мерк Патент Гмбх | Производные пирролидинона в качестве ингибиторов метар-2 |
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HK1186179A1 (zh) | 2014-03-07 |
MX2013004004A (es) | 2013-04-24 |
EP2627631A1 (de) | 2013-08-21 |
US20130296274A1 (en) | 2013-11-07 |
AU2011316199B2 (en) | 2015-07-23 |
JP2013544781A (ja) | 2013-12-19 |
DE102010048374A1 (de) | 2012-04-19 |
CA2814369A1 (en) | 2012-04-19 |
SI2627631T1 (sl) | 2016-04-29 |
PL2627631T3 (pl) | 2016-04-29 |
CN103153951A (zh) | 2013-06-12 |
EA022299B1 (ru) | 2015-12-30 |
CN103153951B (zh) | 2016-05-25 |
IL225626A0 (en) | 2013-06-27 |
BR112013008886A2 (pt) | 2016-06-28 |
KR101803126B1 (ko) | 2017-11-29 |
RS54629B1 (en) | 2016-08-31 |
BR112013008886B1 (pt) | 2021-07-13 |
WO2012048775A1 (de) | 2012-04-19 |
HUE027149T2 (en) | 2016-10-28 |
AU2011316199A1 (en) | 2013-05-02 |
EP2627631B1 (de) | 2015-12-16 |
SG189853A1 (en) | 2013-06-28 |
AR083402A1 (es) | 2013-02-21 |
KR20130143053A (ko) | 2013-12-30 |
ES2563317T3 (es) | 2016-03-14 |
DK2627631T3 (en) | 2016-02-01 |
US8895535B2 (en) | 2014-11-25 |
CA2814369C (en) | 2019-01-15 |
CY1117287T1 (el) | 2017-04-26 |
HRP20160249T1 (hr) | 2016-04-08 |
JP5931885B2 (ja) | 2016-06-08 |
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