BRPI0913580A2 - pirrolopiridinas como inibidores de quinase - Google Patents
pirrolopiridinas como inibidores de quinaseInfo
- Publication number
- BRPI0913580A2 BRPI0913580A2 BRPI0913580A BRPI0913580A BRPI0913580A2 BR PI0913580 A2 BRPI0913580 A2 BR PI0913580A2 BR PI0913580 A BRPI0913580 A BR PI0913580A BR PI0913580 A BRPI0913580 A BR PI0913580A BR PI0913580 A2 BRPI0913580 A2 BR PI0913580A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrolopyridines
- kinase inhibitors
- kinase
- inhibitors
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000005255 pyrrolopyridines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5292608P | 2008-05-13 | 2008-05-13 | |
US61/052,926 | 2008-05-13 | ||
PCT/US2009/043691 WO2009140320A1 (en) | 2008-05-13 | 2009-05-13 | Pyrrolopyridines as kinase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0913580A2 true BRPI0913580A2 (pt) | 2015-10-20 |
BRPI0913580B1 BRPI0913580B1 (pt) | 2020-03-10 |
BRPI0913580B8 BRPI0913580B8 (pt) | 2021-05-25 |
Family
ID=40810786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0913580A BRPI0913580B8 (pt) | 2008-05-13 | 2009-05-13 | compostos de pirrolopiridinas como inibidores de quinase e composição farmacêutica compreendendo os referidos compostos |
Country Status (30)
Country | Link |
---|---|
US (6) | US8178131B2 (pt) |
EP (2) | EP2307409B1 (pt) |
JP (2) | JP5703212B2 (pt) |
KR (2) | KR101643426B1 (pt) |
CN (3) | CN104926810B (pt) |
AR (1) | AR071717A1 (pt) |
AU (1) | AU2009246402B2 (pt) |
BR (1) | BRPI0913580B8 (pt) |
CA (1) | CA2724262C (pt) |
CL (1) | CL2009001152A1 (pt) |
CO (1) | CO6321244A2 (pt) |
CR (1) | CR11803A (pt) |
CY (1) | CY1116692T1 (pt) |
DK (1) | DK2307409T3 (pt) |
ES (1) | ES2552643T3 (pt) |
HK (2) | HK1152035A1 (pt) |
HR (1) | HRP20151018T1 (pt) |
HU (1) | HUE026160T2 (pt) |
IL (1) | IL209258A (pt) |
MX (1) | MX2010012449A (pt) |
NZ (1) | NZ589318A (pt) |
PH (1) | PH12013501779B1 (pt) |
PL (1) | PL2307409T3 (pt) |
PT (1) | PT2307409E (pt) |
RS (1) | RS54358B1 (pt) |
RU (1) | RU2517194C2 (pt) |
SI (1) | SI2307409T1 (pt) |
TW (2) | TWI554512B (pt) |
UA (1) | UA111933C2 (pt) |
WO (1) | WO2009140320A1 (pt) |
Families Citing this family (32)
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EP2242755B1 (en) | 2008-01-08 | 2012-09-12 | Array Biopharma, Inc. | Pyrrolopyridines as kinase inhibitors |
CN101965347B (zh) | 2008-01-09 | 2013-01-02 | 阵列生物制药公司 | 作为激酶抑制剂的吡唑并吡啶 |
JP2009256298A (ja) * | 2008-03-26 | 2009-11-05 | Sumitomo Chemical Co Ltd | ピペリジン−3−イルカーバメート化合物の光学分割方法およびその中間体 |
CL2009001152A1 (es) | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. |
US8481557B2 (en) | 2009-04-11 | 2013-07-09 | Array Biopharma Inc. | Method of treatment using checkpoint kinase 1 inhibitors |
AU2010233122B2 (en) * | 2009-04-11 | 2015-09-17 | Array Biopharma Inc. | Checkpoint kinase 1 inhibitors for potentiating DNA damaging agents |
TWI466885B (zh) | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
EP2485589A4 (en) * | 2009-09-04 | 2013-02-06 | Biogen Idec Inc | HETEROARYARY INHIBITORS OF BTK |
KR101541086B1 (ko) | 2010-08-20 | 2015-08-03 | 허치슨 메디파르마 리미티드 | 피롤로피리미딘 화합물 및 그 용도 |
JP6091422B2 (ja) * | 2010-11-16 | 2017-03-08 | アレイ バイオファーマ、インコーポレイテッド | チェックポイントキナーゼ1阻害剤とwee1キナーゼ阻害剤の組み合わせ |
ES2563152T3 (es) | 2011-02-25 | 2016-03-11 | Array Biopharma Inc. | Compuestos de triazolopiridina como inhibidores de quinasa PIM |
JP2014516941A (ja) | 2011-04-29 | 2014-07-17 | アムジェン インコーポレイテッド | Pim阻害剤としての二環式ピリダジン化合物 |
GB201201566D0 (en) | 2012-01-30 | 2012-03-14 | Vernalis R&D Ltd | New chemical compounds |
SG11201406818VA (en) | 2012-04-23 | 2014-11-27 | Genentech Inc | Intermediates and processes for preparing compounds |
AU2014293011A1 (en) | 2013-07-26 | 2016-03-17 | Race Oncology Ltd. | Compositions to improve the therapeutic benefit of bisantrene |
WO2015027090A1 (en) * | 2013-08-22 | 2015-02-26 | Genentech, Inc. | Intermediates and processes for preparing compounds |
MX369174B (es) * | 2013-08-22 | 2019-10-30 | Genentech Inc | Proceso para la preparación de un compuesto. |
WO2015048318A1 (en) | 2013-09-25 | 2015-04-02 | Vertex Pharmaceuticals Incorporated | A selective inhibitor of phosphatidylinositol 3-kinase-gamma |
EP3125920B1 (en) | 2014-04-04 | 2020-12-23 | Del Mar Pharmaceuticals | Dianhydrogalactitol, diacetyldianhydrogalactitol or dibromodulcitol to treat non-small-cell carcinoma of the lung and ovarian cancer |
AR101106A1 (es) | 2014-07-02 | 2016-11-23 | Pharmacyclics Llc | Inhibidores de tirosina quinasa de bruton |
MA41599A (fr) | 2015-02-26 | 2018-01-02 | Array Biopharma Inc | Formes cristallines d'un composé pyrrolopyridine |
WO2017003090A1 (ko) | 2015-06-30 | 2017-01-05 | 서울바이오시스 주식회사 | Uv led가 적용된 포충기 |
LT3371165T (lt) * | 2015-11-04 | 2022-05-10 | Merck Patent Gmbh | Btk inhibitorius, naudojamas vėžiui gydyti |
AU2016378579A1 (en) * | 2015-12-22 | 2018-06-14 | Vitae Pharmaceuticals, Inc. | Inhibitors of the menin-MLL interaction |
KR102436430B1 (ko) | 2016-06-10 | 2022-08-24 | 비타이 파마슈티컬즈, 엘엘씨 | 메닌-mll 상호 작용의 억제제 |
EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
MA53095A (fr) | 2018-07-03 | 2021-05-12 | Ifm Due Inc | Composés et compositions pour traiter des états pathologiques associés à une activité de sting |
CN108912032A (zh) * | 2018-08-13 | 2018-11-30 | 南通大学 | 一种(3s,4r)-4-甲基吡咯烷-3-基氨基甲醇叔丁酯盐酸盐的化学合成方法 |
CN109053526A (zh) * | 2018-08-13 | 2018-12-21 | 南通大学 | 一种(3r,4s)-4-甲基吡咯烷-3-基氨基甲酸叔丁酯盐酸盐的化学合成方法 |
WO2020150417A2 (en) | 2019-01-17 | 2020-07-23 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
JP2023540673A (ja) | 2020-07-15 | 2023-09-26 | アイエフエム デュー インコーポレイテッド | Sting活性に関連する状態を治療するための化合物および組成物 |
TW202311262A (zh) | 2021-05-14 | 2023-03-16 | 美商錫達斯醫藥股份有限公司 | Menin-mll交互作用之抑制劑 |
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EP2242755B1 (en) * | 2008-01-08 | 2012-09-12 | Array Biopharma, Inc. | Pyrrolopyridines as kinase inhibitors |
CN101965347B (zh) | 2008-01-09 | 2013-01-02 | 阵列生物制药公司 | 作为激酶抑制剂的吡唑并吡啶 |
CL2009001152A1 (es) | 2008-05-13 | 2009-10-16 | Array Biopharma Inc | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. |
US8481557B2 (en) * | 2009-04-11 | 2013-07-09 | Array Biopharma Inc. | Method of treatment using checkpoint kinase 1 inhibitors |
US20140221370A1 (en) | 2010-07-09 | 2014-08-07 | Array Biopharma Inc. | Pyrrolopyridines as kinase inhibitors |
JP6091422B2 (ja) | 2010-11-16 | 2017-03-08 | アレイ バイオファーマ、インコーポレイテッド | チェックポイントキナーゼ1阻害剤とwee1キナーゼ阻害剤の組み合わせ |
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2009
- 2009-05-12 CL CL2009001152A patent/CL2009001152A1/es unknown
- 2009-05-12 AR ARP090101708A patent/AR071717A1/es active IP Right Grant
- 2009-05-13 KR KR1020107027941A patent/KR101643426B1/ko active IP Right Grant
- 2009-05-13 AU AU2009246402A patent/AU2009246402B2/en not_active Ceased
- 2009-05-13 EP EP09747404.3A patent/EP2307409B1/en active Active
- 2009-05-13 PL PL09747404T patent/PL2307409T3/pl unknown
- 2009-05-13 MX MX2010012449A patent/MX2010012449A/es active IP Right Grant
- 2009-05-13 EP EP15175131.0A patent/EP2990407B1/en active Active
- 2009-05-13 RS RS20150711A patent/RS54358B1/en unknown
- 2009-05-13 US US12/992,468 patent/US8178131B2/en active Active
- 2009-05-13 RU RU2010150786/04A patent/RU2517194C2/ru active
- 2009-05-13 TW TW103133772A patent/TWI554512B/zh active
- 2009-05-13 JP JP2011509628A patent/JP5703212B2/ja not_active Expired - Fee Related
- 2009-05-13 UA UAA201015012A patent/UA111933C2/uk unknown
- 2009-05-13 CN CN201510289964.7A patent/CN104926810B/zh active Active
- 2009-05-13 NZ NZ589318A patent/NZ589318A/en not_active IP Right Cessation
- 2009-05-13 ES ES09747404.3T patent/ES2552643T3/es active Active
- 2009-05-13 WO PCT/US2009/043691 patent/WO2009140320A1/en active Application Filing
- 2009-05-13 CA CA2724262A patent/CA2724262C/en active Active
- 2009-05-13 HU HUE09747404A patent/HUE026160T2/en unknown
- 2009-05-13 PT PT97474043T patent/PT2307409E/pt unknown
- 2009-05-13 DK DK09747404.3T patent/DK2307409T3/en active
- 2009-05-13 TW TW098115906A patent/TWI458727B/zh active
- 2009-05-13 CN CN200980127299.4A patent/CN102089307B/zh active Active
- 2009-05-13 SI SI200931284T patent/SI2307409T1/sl unknown
- 2009-05-13 KR KR1020147015705A patent/KR101657856B1/ko active IP Right Grant
- 2009-05-13 CN CN201910068067.1A patent/CN109942575A/zh active Pending
- 2009-05-13 BR BRPI0913580A patent/BRPI0913580B8/pt not_active IP Right Cessation
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2010
- 2010-11-11 IL IL209258A patent/IL209258A/en active IP Right Grant
- 2010-11-19 CR CR11803A patent/CR11803A/es unknown
- 2010-11-30 CO CO10150963A patent/CO6321244A2/es active IP Right Grant
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2011
- 2011-06-14 HK HK11106054.7A patent/HK1152035A1/xx not_active IP Right Cessation
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2012
- 2012-03-20 US US13/425,186 patent/US8545897B2/en active Active
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2013
- 2013-08-23 US US13/974,895 patent/US8758830B2/en active Active
- 2013-08-28 PH PH12013501779A patent/PH12013501779B1/en unknown
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2014
- 2014-05-06 US US14/271,129 patent/US8981085B2/en active Active
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2015
- 2015-01-07 US US14/591,691 patent/US9365568B2/en active Active
- 2015-02-23 JP JP2015032474A patent/JP2015098482A/ja not_active Withdrawn
- 2015-09-16 CY CY20151100812T patent/CY1116692T1/el unknown
- 2015-09-28 HR HRP20151018TT patent/HRP20151018T1/hr unknown
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2016
- 2016-01-05 US US14/988,521 patent/US9969727B2/en active Active
- 2016-07-08 HK HK16107983.6A patent/HK1219950A1/zh unknown
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