BRPI0914305A2 - Compostos de piridazina carboxamida substituída como compostos inibidores da quinase - Google Patents
Compostos de piridazina carboxamida substituída como compostos inibidores da quinaseInfo
- Publication number
- BRPI0914305A2 BRPI0914305A2 BRPI0914305-0A BRPI0914305A BRPI0914305A2 BR PI0914305 A2 BRPI0914305 A2 BR PI0914305A2 BR PI0914305 A BRPI0914305 A BR PI0914305A BR PI0914305 A2 BRPI0914305 A2 BR PI0914305A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- kinase inhibitor
- substituted carboxamide
- carboxamide pyridazine
- inhibitor compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13250508P | 2008-06-19 | 2008-06-19 | |
| US61/132,505 | 2008-06-19 | ||
| PCT/US2009/003654 WO2009154769A1 (en) | 2008-06-19 | 2009-06-18 | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0914305A2 true BRPI0914305A2 (pt) | 2015-08-11 |
| BRPI0914305B1 BRPI0914305B1 (pt) | 2021-05-11 |
| BRPI0914305B8 BRPI0914305B8 (pt) | 2021-05-25 |
Family
ID=41434356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0914305A BRPI0914305B8 (pt) | 2008-06-19 | 2009-06-18 | compostos de piridazina carboxamida substituída como compostos inibidores da quinase, uso dos compostos e uso de uma composição compreendendo os compostos |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8697866B2 (pt) |
| EP (2) | EP2303018B1 (pt) |
| JP (1) | JP5670325B2 (pt) |
| KR (1) | KR101691640B1 (pt) |
| CN (1) | CN102098917B (pt) |
| AU (1) | AU2009260810B2 (pt) |
| BR (1) | BRPI0914305B8 (pt) |
| CA (1) | CA2728408C (pt) |
| ES (2) | ES2551899T3 (pt) |
| IL (1) | IL210099A (pt) |
| MX (1) | MX2010014171A (pt) |
| NZ (1) | NZ590542A (pt) |
| PL (1) | PL2303018T3 (pt) |
| RU (1) | RU2526618C2 (pt) |
| WO (1) | WO2009154769A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ590542A (en) * | 2008-06-19 | 2012-12-21 | Xcovery Holding Co Llc | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds |
| WO2011117286A1 (en) * | 2010-03-23 | 2011-09-29 | Basf Se | Pyridazine compounds for controlling invertebrate pests |
| EA025030B1 (ru) * | 2010-10-08 | 2016-11-30 | Икскавери Холдинг Кампани, Ллс | Соединение {5-[(1r)-1-(2,6-дихлор-3-фторфенил)этокси]-6-аминопиридазин-3-ил}-n-(1-метил-6-оксо-1,6-дигидропиридин-3-ил)карбоксамид в качестве киназного ингибитора |
| WO2012048259A2 (en) * | 2010-10-08 | 2012-04-12 | Xcovery Holding Company, Llc | Substituted pyridazine carboxamide compounds |
| EP2900657B1 (en) | 2012-09-26 | 2020-03-11 | F.Hoffmann-La Roche Ag | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| CN102952091A (zh) * | 2012-10-19 | 2013-03-06 | 盛世泰科生物医药技术(苏州)有限公司 | 一种4-氨基异恶唑盐酸盐的合成方法 |
| RU2550346C2 (ru) * | 2013-09-26 | 2015-05-10 | Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" | Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний |
| TWI646094B (zh) * | 2016-06-01 | 2019-01-01 | 大陸商貝達藥業股份有限公司 | Crystal form of inhibitory protein kinase active compound and application thereof |
| BR112021001263A2 (pt) * | 2018-07-24 | 2021-04-27 | Epizyme, Inc. | compostos, seus usos, método para tratar câncer e método para modular uma atividade de smarca2 |
| EP3898589A2 (de) * | 2018-12-21 | 2021-10-27 | Saltigo GmbH | Verfahren zur herstellung von 2-alkoxy-4-amino-5-methyl-pyridinen und/oder von 2-alkoxy-4-alkylamino-5-methyl-pyridinen |
| CN112457268A (zh) * | 2020-12-11 | 2021-03-09 | 平江县吉成科技有限责任公司 | 一种温和的4-氨基异恶唑盐酸盐的合成方法 |
| CN116082110B (zh) * | 2023-01-09 | 2024-04-12 | 北京肿瘤医院(北京大学肿瘤医院) | 一种11c标记靶向间变性淋巴瘤激酶alk突变分子探针及应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4369172A (en) | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| EP0188040B1 (en) | 1985-01-11 | 1991-08-14 | Abbott Laboratories Limited | Slow release solid preparation |
| JP2773959B2 (ja) | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| EP1101490B1 (en) | 1998-07-28 | 2005-04-13 | Tanabe Seiyaku Co., Ltd. | Preparation capable of releasing drug at target site in intestine |
| US6461631B1 (en) | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| CN1556788A (zh) * | 2001-09-21 | 2004-12-22 | 毒蕈碱受体激动剂 | |
| US6800663B2 (en) | 2002-10-18 | 2004-10-05 | Alkermes Controlled Therapeutics Inc. Ii, | Crosslinked hydrogel copolymers |
| OA13151A (en) * | 2003-02-26 | 2006-12-13 | Sugen Inc | Aminoheteroaryl compounds as protein kinase inhibitors. |
| EP1689387B1 (en) * | 2003-11-19 | 2011-09-14 | Array Biopharma, Inc. | Bicyclic inhibitors of mek and methods of synthesis thereof |
| JP2008510792A (ja) | 2004-08-26 | 2008-04-10 | ファイザー・インク | タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物 |
| PT1784396E (pt) | 2004-08-26 | 2011-01-27 | Pfizer | Compostos amino-heteroarílicos substituídos com pirazole como inibidores de proteína quinases |
| MX2007003377A (es) * | 2004-09-23 | 2007-05-10 | Pfizer Prod Inc | Agonistas del receptor de trombopoyetina. |
| WO2006058905A1 (en) * | 2004-12-01 | 2006-06-08 | Devgen Nv | 5-CARBOXAMIDO SUBSTITUTED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE Kv FAMILY |
| US7601355B2 (en) * | 2005-06-01 | 2009-10-13 | Northwestern University | Compositions and methods for altering immune function |
| US7745477B2 (en) * | 2006-02-07 | 2010-06-29 | Hoffman-La Roche Inc. | Heteroaryl and benzyl amide compounds |
| WO2007123939A2 (en) * | 2006-04-19 | 2007-11-01 | Laboratoires Serono S.A. | Novel arylamino n-heteraryls as mek inhibitors |
| EP2120578B1 (en) * | 2007-01-19 | 2014-11-19 | Xcovery, INC. | Kinase inhibitor compounds |
| TW200918521A (en) * | 2007-08-31 | 2009-05-01 | Astrazeneca Ab | Heterocyclic amides and methods of use thereof |
| NZ590542A (en) * | 2008-06-19 | 2012-12-21 | Xcovery Holding Co Llc | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds |
| MX2011011477A (es) * | 2009-05-05 | 2011-11-18 | Hoffmann La Roche | Derivados de isoxazol-piridazina. |
| US8669254B2 (en) * | 2010-12-15 | 2014-03-11 | Hoffman-La Roche Inc. | Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents |
-
2009
- 2009-06-18 NZ NZ590542A patent/NZ590542A/xx unknown
- 2009-06-18 ES ES09767082.2T patent/ES2551899T3/es active Active
- 2009-06-18 PL PL09767082T patent/PL2303018T3/pl unknown
- 2009-06-18 ES ES15189299.9T patent/ES2670665T3/es active Active
- 2009-06-18 EP EP09767082.2A patent/EP2303018B1/en active Active
- 2009-06-18 RU RU2011139352/04A patent/RU2526618C2/ru active
- 2009-06-18 WO PCT/US2009/003654 patent/WO2009154769A1/en active Application Filing
- 2009-06-18 KR KR1020117001272A patent/KR101691640B1/ko active IP Right Grant
- 2009-06-18 MX MX2010014171A patent/MX2010014171A/es active IP Right Grant
- 2009-06-18 AU AU2009260810A patent/AU2009260810B2/en active Active
- 2009-06-18 US US12/997,980 patent/US8697866B2/en active Active
- 2009-06-18 BR BRPI0914305A patent/BRPI0914305B8/pt active IP Right Grant
- 2009-06-18 JP JP2011514617A patent/JP5670325B2/ja active Active
- 2009-06-18 CN CN200980128355.6A patent/CN102098917B/zh active Active
- 2009-06-18 CA CA2728408A patent/CA2728408C/en active Active
- 2009-06-18 EP EP15189299.9A patent/EP3061752B1/en active Active
-
2010
- 2010-12-19 IL IL210099A patent/IL210099A/en active IP Right Grant
-
2014
- 2014-04-09 US US14/249,245 patent/US9296724B2/en active Active
-
2016
- 2016-02-29 US US15/056,182 patent/US20160176900A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2303018A1 (en) | 2011-04-06 |
| KR20110044974A (ko) | 2011-05-03 |
| CA2728408A1 (en) | 2009-12-23 |
| ES2670665T3 (es) | 2018-05-31 |
| CN102098917A (zh) | 2011-06-15 |
| MX2010014171A (es) | 2011-07-04 |
| RU2526618C2 (ru) | 2014-08-27 |
| CN102098917B (zh) | 2016-03-16 |
| WO2009154769A1 (en) | 2009-12-23 |
| US20140221376A1 (en) | 2014-08-07 |
| RU2011139352A (ru) | 2013-04-10 |
| JP2011524905A (ja) | 2011-09-08 |
| IL210099A0 (en) | 2011-02-28 |
| ES2551899T3 (es) | 2015-11-24 |
| US20110160209A1 (en) | 2011-06-30 |
| US20160176900A1 (en) | 2016-06-23 |
| KR101691640B1 (ko) | 2016-12-30 |
| CA2728408C (en) | 2017-12-05 |
| AU2009260810B2 (en) | 2015-09-17 |
| BRPI0914305B8 (pt) | 2021-05-25 |
| IL210099A (en) | 2015-11-30 |
| EP2303018A4 (en) | 2012-06-20 |
| EP3061752B1 (en) | 2018-02-21 |
| US8697866B2 (en) | 2014-04-15 |
| EP3061752A1 (en) | 2016-08-31 |
| US9296724B2 (en) | 2016-03-29 |
| JP5670325B2 (ja) | 2015-02-18 |
| BRPI0914305B1 (pt) | 2021-05-11 |
| PL2303018T3 (pl) | 2016-06-30 |
| EP2303018B1 (en) | 2015-10-14 |
| NZ590542A (en) | 2012-12-21 |
| AU2009260810A1 (en) | 2009-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B25F | Entry of change of name and/or headquarter and transfer of application, patent and certif. of addition of invention: change of name on requirement |
Owner name: XCOVERY HOLDING COMPANY LLC (US) Free format text: A FIM DE ATENDER A(S) ALTERACAO(OES) DE NOME REQUERIDA(S) ATRAVES DA PETICAO NO870200054923 DE 04/05/2020, E NECESSARIO:1. ESCLARECER A DIVERGENCIA QUE HA ENTRE O ENDERECO APRESENTADO NA PETICAO SUPRA E OENDERECO DA TITULAR, CONFORME PETICAO 020100118583 DE 20/12/2010;2. APRESENTAR GRU REFERENTE AO CUMPRIMENTO DA PRESENTE EXIGENCIA. |
|
| B25D | Requested change of name of applicant approved |
Owner name: XCOVERY HOLDINGS, INC. (US) |
|
| B25G | Requested change of headquarter approved |
Owner name: XCOVERY HOLDINGS, INC. (US) |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
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