CL2008001933A1 - Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. - Google Patents

Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros.

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Publication number
CL2008001933A1
CL2008001933A1 CL2008001933A CL2008001933A CL2008001933A1 CL 2008001933 A1 CL2008001933 A1 CL 2008001933A1 CL 2008001933 A CL2008001933 A CL 2008001933A CL 2008001933 A CL2008001933 A CL 2008001933A CL 2008001933 A1 CL2008001933 A1 CL 2008001933A1
Authority
CL
Chile
Prior art keywords
compounds
disorder
cardiac
bone
neurodegenerative
Prior art date
Application number
CL2008001933A
Other languages
English (en)
Inventor
Weirong Chen
Jennifer Cossrow
Lloyd Franklin
Bing Guan
Gnanasambandam Kumaravel
Benjamin Lane
Adam Littke
Jones John Howard
Original Assignee
Millennium Pharm Inc
Sunesis Pharmaceuticals Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40029124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008001933(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc, Sunesis Pharmaceuticals Inc filed Critical Millennium Pharm Inc
Publication of CL2008001933A1 publication Critical patent/CL2008001933A1/es

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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

LA PRESENTE INVENCIÓN DESCRIBE COMPUESTOS DE FÓRMULA I , DONDE CY1, CY2 , L1 , L2 , R1 , RX Y RY SON COMO SE DEFINEN EN EL PLIEGO DE REIVINDICACIONES; ADICIONALMENTE SE DESCRIBEN LA COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; EL PROCESO DE PREPARACIÓN DE LOS MISMOS; COMPUESTOS INTERMEDIARIOS; Y EL USO DE LOS COMPUESTOS EN EL TRATAMIENTO DE TRASTORNOS MEDIADO POR RAF EN UN MAMÍFERO TALES COMO TRASTORNO PROLIFERATIVO, UN TRASTORNO CARDIACO, UN TRASTORNO NEURODEGENERATIVO, UN TRASTORNO AUTOINMUNE, UNA AFECCIÓN ASOCIADA CON TRASPLANTE DE ÓRGANOS, UN TRASTORNO INFLAMATORIO, UN TRASTORNO MEDIADO INMUNOLÓGICAMENTE, UNA ENFERMEDAD VIRAL, UN TRASTORNO ÓSEO, ENTRE OTROS
CL2008001933A 2007-06-29 2008-06-27 Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. CL2008001933A1 (es)

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