EA201490807A1 - Новые замещенные имидазопиримидины как модуляторы рецептора gpbar1 - Google Patents
Новые замещенные имидазопиримидины как модуляторы рецептора gpbar1Info
- Publication number
- EA201490807A1 EA201490807A1 EA201490807A EA201490807A EA201490807A1 EA 201490807 A1 EA201490807 A1 EA 201490807A1 EA 201490807 A EA201490807 A EA 201490807A EA 201490807 A EA201490807 A EA 201490807A EA 201490807 A1 EA201490807 A1 EA 201490807A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- imidazopirimidines
- compounds
- new substituted
- gpbar1
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к новым замещенным имидазо[1,2-а]пиримидиновым соединениям формулы (I), их фармацевтически приемлемым солям и их изомерам, стереоизомерам, конформерам, таутомерам, полиморфам, гидратам и сольватам. Изобретение также охватывает фармацевтически приемлемые композиции указанных соединений и способ получения новых соединений. Настоящее изобретение, кроме того, относится к применению вышеупомянутых соединений с целью получения лекарственного препарата для применения в качестве фармацевтических средств.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1352KO2011 | 2011-10-21 | ||
PCT/IB2012/055598 WO2013057650A1 (en) | 2011-10-21 | 2012-10-15 | Novel substituted imidazopyrimidines as gpbar1 receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201490807A1 true EA201490807A1 (ru) | 2014-07-30 |
Family
ID=54256944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490807A EA201490807A1 (ru) | 2011-10-21 | 2012-10-15 | Новые замещенные имидазопиримидины как модуляторы рецептора gpbar1 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20150126530A1 (ru) |
EP (1) | EP2768832A1 (ru) |
JP (1) | JP2014530850A (ru) |
KR (1) | KR20140090637A (ru) |
CN (1) | CN104024260A (ru) |
AU (1) | AU2012324517A1 (ru) |
BR (1) | BR112014009114A2 (ru) |
CA (1) | CA2852615A1 (ru) |
EA (1) | EA201490807A1 (ru) |
IL (1) | IL232112A0 (ru) |
SG (1) | SG11201401359SA (ru) |
WO (1) | WO2013057650A1 (ru) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2928164T3 (es) | 2015-10-19 | 2022-11-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
MX2018006207A (es) | 2015-11-19 | 2018-09-05 | Incyte Corp | Compuestos heterociclicos como inmunomoduladores. |
EA201891494A1 (ru) | 2015-12-22 | 2019-01-31 | Инсайт Корпорейшн | Гетероциклические соединения в качестве иммуномодуляторов |
EP3452476B1 (en) | 2016-05-06 | 2021-12-15 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
US20190185548A1 (en) * | 2016-06-07 | 2019-06-20 | Abivax | Antiviral polyclonal antibodies against ebola virus and the uses thereof |
HUE060256T2 (hu) | 2016-06-20 | 2023-02-28 | Incyte Corp | Heterociklusos vegyületek mint immunmodulátorok |
US20180016260A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2018044783A1 (en) | 2016-08-29 | 2018-03-08 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
HRP20221216T1 (hr) | 2016-12-22 | 2022-12-23 | Incyte Corporation | Derivati tetrahidro imidazo[4,5-c]piridina kao induktori internalizacije pd-l1 |
EP3558973B1 (en) | 2016-12-22 | 2021-09-15 | Incyte Corporation | Pyridine derivatives as immunomodulators |
WO2018119236A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
KR20190111025A (ko) | 2016-12-22 | 2019-10-01 | 인사이트 코포레이션 | 면역조절제로서의 벤조옥사졸 유도체 |
HRP20230090T1 (hr) | 2018-03-30 | 2023-03-17 | Incyte Corporation | Heterociklički spojevi kao imunomodulatori |
SG11202011165TA (en) | 2018-05-11 | 2020-12-30 | Incyte Corp | Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators |
MX2022001671A (es) | 2019-08-09 | 2022-05-13 | Incyte Corp | Sales de un inhibidor de pd-1/pd-l1. |
EP4037773A1 (en) | 2019-09-30 | 2022-08-10 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
AU2020385113A1 (en) | 2019-11-11 | 2022-05-19 | Incyte Corporation | Salts and crystalline forms of a PD-1/PD-L1 inhibitor |
US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
JP2023548859A (ja) | 2020-11-06 | 2023-11-21 | インサイト・コーポレイション | Pd-1/pd-l1阻害剤ならびにその塩及び結晶形態を作製するためのプロセス |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2514547A1 (en) | 2003-01-28 | 2004-08-12 | Takeda Pharmaceutical Company Limited | Receptor agonists |
US20080031968A1 (en) | 2005-04-01 | 2008-02-07 | The Brigham And Women's Hospital, Inc. | Methods for increasing cellular energy expenditure |
AU2007325315A1 (en) | 2006-11-28 | 2008-06-05 | Kalypsys Inc | Heterocyclic modulators of TGR5 |
DE102007048716A1 (de) * | 2007-10-11 | 2009-04-23 | Merck Patent Gmbh | Imidazo[1,2-a]pyrimidinderivate |
FR2925903B1 (fr) * | 2008-01-02 | 2011-01-21 | Sanofi Aventis | DERIVES 6-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
CA2741153A1 (en) * | 2008-10-29 | 2010-05-06 | F. Hoffmann-La Roche Ag | Novel phenyl amide or pyridyl amide derivatives and their use as gpbar1 agonists |
EP2496578A4 (en) | 2009-11-05 | 2013-08-21 | Univ Notre Dame Du Lac | IMIDAZO [1,2-A] PYRIDINE COMPOUNDS, THEIR SYNTHESIS AND METHODS OF USE THEREOF |
NZ602311A (en) * | 2010-03-18 | 2014-08-29 | Pasteur Institut Korea | Anti-infective compounds |
-
2012
- 2012-10-15 WO PCT/IB2012/055598 patent/WO2013057650A1/en active Application Filing
- 2012-10-15 EA EA201490807A patent/EA201490807A1/ru unknown
- 2012-10-15 CN CN201280064135.3A patent/CN104024260A/zh active Pending
- 2012-10-15 AU AU2012324517A patent/AU2012324517A1/en not_active Abandoned
- 2012-10-15 BR BR112014009114A patent/BR112014009114A2/pt not_active IP Right Cessation
- 2012-10-15 US US14/352,293 patent/US20150126530A1/en not_active Abandoned
- 2012-10-15 KR KR1020147013665A patent/KR20140090637A/ko not_active Application Discontinuation
- 2012-10-15 EP EP12791857.1A patent/EP2768832A1/en not_active Withdrawn
- 2012-10-15 CA CA2852615A patent/CA2852615A1/en not_active Abandoned
- 2012-10-15 SG SG11201401359SA patent/SG11201401359SA/en unknown
- 2012-10-15 JP JP2014536381A patent/JP2014530850A/ja active Pending
-
2014
- 2014-04-13 IL IL232112A patent/IL232112A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112014009114A2 (pt) | 2017-04-11 |
WO2013057650A1 (en) | 2013-04-25 |
SG11201401359SA (en) | 2014-05-29 |
JP2014530850A (ja) | 2014-11-20 |
CA2852615A1 (en) | 2013-04-25 |
AU2012324517A1 (en) | 2014-05-22 |
KR20140090637A (ko) | 2014-07-17 |
IL232112A0 (en) | 2014-05-28 |
US20150126530A1 (en) | 2015-05-07 |
CN104024260A (zh) | 2014-09-03 |
EP2768832A1 (en) | 2014-08-27 |
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