MX2022007842A - Derivados biciclicos sustituidos de piperidina utiles como activadores de celulas t. - Google Patents

Derivados biciclicos sustituidos de piperidina utiles como activadores de celulas t.

Info

Publication number
MX2022007842A
MX2022007842A MX2022007842A MX2022007842A MX2022007842A MX 2022007842 A MX2022007842 A MX 2022007842A MX 2022007842 A MX2022007842 A MX 2022007842A MX 2022007842 A MX2022007842 A MX 2022007842A MX 2022007842 A MX2022007842 A MX 2022007842A
Authority
MX
Mexico
Prior art keywords
sub
derivatives useful
piperidine derivatives
substituted bicyclic
cell activators
Prior art date
Application number
MX2022007842A
Other languages
English (en)
Inventor
Robert G Gentles
Jayakumar Sankara Warrier
Scott W Martin
Min Ding
Richard E Olson
Upender Velaparthi
Saumya Roy
Prasada Rao Jalagam
Denise Grunenfelder
Louis CHUPAK
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2022007842A publication Critical patent/MX2022007842A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Se describen compuestos de la Fórmula (I): (ver Fórmula) o una sal de los mismos, en donde: X es CR6 o N; Y es CR3 o N; R1, R2, R3, R4, R5, R6, R7, y m son como se definen en la presente. También se describen métodos para usar tales compuestos para inhibir la actividad de uno o ambos de diacilglicerol cinasa alfa (DGKa) y diacilglicerol cinasa zeta (DGK?), y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles en el tratamiento de infecciones virales y trastornos proliferativos, como el cáncer.
MX2022007842A 2019-12-23 2020-12-22 Derivados biciclicos sustituidos de piperidina utiles como activadores de celulas t. MX2022007842A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201911053552 2019-12-23
PCT/US2020/066507 WO2021133750A1 (en) 2019-12-23 2020-12-22 Substituted bicyclic piperidine derivatives useful as t cell activators

Publications (1)

Publication Number Publication Date
MX2022007842A true MX2022007842A (es) 2022-07-19

Family

ID=74191945

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022007842A MX2022007842A (es) 2019-12-23 2020-12-22 Derivados biciclicos sustituidos de piperidina utiles como activadores de celulas t.

Country Status (16)

Country Link
US (1) US11964973B2 (es)
EP (1) EP4081523A1 (es)
JP (1) JP2023508052A (es)
KR (1) KR20220119455A (es)
CN (1) CN114901660A (es)
AR (1) AR120823A1 (es)
AU (1) AU2020412615A1 (es)
BR (1) BR112022012195A2 (es)
CA (1) CA3163013A1 (es)
CL (1) CL2022001710A1 (es)
CO (1) CO2022008675A2 (es)
IL (1) IL294272A (es)
MX (1) MX2022007842A (es)
PE (1) PE20221487A1 (es)
TW (1) TW202136254A (es)
WO (1) WO2021133750A1 (es)

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US11976072B2 (en) 2021-06-23 2024-05-07 Gilead Sciences, Inc. Diacylglycerol kinase modulating compounds
CA3220923A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2023122778A1 (en) * 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Pyridazinone derivatives useful as t cell activators
WO2023150186A1 (en) * 2022-02-01 2023-08-10 Arvinas Operations, Inc. Dgk targeting compounds and uses thereof
WO2023165525A1 (en) * 2022-03-01 2023-09-07 Insilico Medicine Ip Limited Diacylglycerol kinase (dgk) alpha inhibitors and uses thereof
WO2023184327A1 (en) * 2022-03-31 2023-10-05 InventisBio Co., Ltd. Kinase inhibitors, preparation methods and uses thereof

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Also Published As

Publication number Publication date
WO2021133750A1 (en) 2021-07-01
US20210188845A1 (en) 2021-06-24
EP4081523A1 (en) 2022-11-02
CO2022008675A2 (es) 2022-07-19
PE20221487A1 (es) 2022-09-26
CA3163013A1 (en) 2021-07-01
BR112022012195A2 (pt) 2022-09-06
CL2022001710A1 (es) 2023-01-13
JP2023508052A (ja) 2023-02-28
AU2020412615A1 (en) 2022-08-18
IL294272A (en) 2022-08-01
CN114901660A (zh) 2022-08-12
KR20220119455A (ko) 2022-08-29
TW202136254A (zh) 2021-10-01
AR120823A1 (es) 2022-03-23
US11964973B2 (en) 2024-04-23

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