WO2008132138A9 - Derivatives of 4,6-disubstituted aminopyrimidines - Google Patents
Derivatives of 4,6-disubstituted aminopyrimidines Download PDFInfo
- Publication number
- WO2008132138A9 WO2008132138A9 PCT/EP2008/055015 EP2008055015W WO2008132138A9 WO 2008132138 A9 WO2008132138 A9 WO 2008132138A9 EP 2008055015 W EP2008055015 W EP 2008055015W WO 2008132138 A9 WO2008132138 A9 WO 2008132138A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- derivatives
- disubstituted aminopyrimidines
- methylenesulfonamide
- methylenesulfone
- acceptable salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
The present invention relates to methylenesulfone and methylenesulfonamide derivatives of 4,6-disubstituted aminopyrimidines having the general formula (II) as given below and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or the treatment of cell proliferative diseases, inflammation, cardiac hypertrophy and infectious diseases, especially viral infections such as HIV. Furthermore, the present invention is directed towards pharmaceutical composition containing at least one of the methylenesulfone or methylenesulfonamide derivatives of 4,6-disubstituted aminopyrimidines and/or pharmaceutically acceptable salts thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07106951 | 2007-04-25 | ||
EP07106951.2 | 2007-04-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008132138A1 WO2008132138A1 (en) | 2008-11-06 |
WO2008132138A9 true WO2008132138A9 (en) | 2008-12-31 |
Family
ID=38515868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/055015 WO2008132138A1 (en) | 2007-04-25 | 2008-04-24 | Derivatives of 4,6-disubstituted aminopyrimidines |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008132138A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU0900798D0 (en) | 2009-12-21 | 2010-03-01 | Vichem Chemie Kutato Kft | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
WO2012066065A1 (en) * | 2010-11-17 | 2012-05-24 | Novartis Ag | Phenyl-heteroaryl amine compounds and their uses |
US9242937B2 (en) | 2011-03-02 | 2016-01-26 | Bayer Intellectual Property Gmbh | Pharmaceutically active disubstituted pyridine derivatives |
US9226929B2 (en) | 2011-03-02 | 2016-01-05 | Bayer Intellectual Property Gmbh | Pharmaceutically active disubstituted triazine derivatives |
TWI555737B (en) | 2011-05-24 | 2016-11-01 | 拜耳知識產權公司 | 4-aryl-n-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group |
EP2562265A1 (en) | 2011-08-22 | 2013-02-27 | Lead Discovery Center GmbH | Susceptibility to selective CDK9 inhibitors |
EP2561867A1 (en) | 2011-08-22 | 2013-02-27 | Lead Discovery Center GmbH | CDK9 inhibitors in the treatment of midline carcinoma |
CA2888383A1 (en) | 2012-10-18 | 2014-04-24 | Bayer Pharma Aktiengesellschaft | N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group |
CA2888371C (en) | 2012-10-18 | 2021-06-08 | Ulrich Lucking | 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group |
KR102242871B1 (en) | 2012-11-15 | 2021-04-20 | 바이엘 파마 악티엔게젤샤프트 | 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group |
TW201418243A (en) * | 2012-11-15 | 2014-05-16 | Bayer Pharma AG | N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfoximine group |
US20150368209A1 (en) * | 2013-01-07 | 2015-12-24 | École Polytechnique Fédérale De Lausanne (Epfl) | 4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections |
EP2769722A1 (en) * | 2013-02-22 | 2014-08-27 | Ruprecht-Karls-Universität Heidelberg | Compounds for use in inhibiting HIV capsid assembly |
CA2917096C (en) | 2013-07-04 | 2021-05-18 | Bayer Pharma Aktiengesellschaft | Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors |
US9856242B2 (en) | 2014-03-13 | 2018-01-02 | Bayer Pharma Aktiengesellscaft | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group |
US9790189B2 (en) | 2014-04-01 | 2017-10-17 | Bayer Pharma Aktiengesellschaft | Disubstituted 5-fluoro pyrimidine derivatives containing a sulfondiimine group |
CN106459084B (en) | 2014-04-11 | 2019-04-19 | 拜耳医药股份有限公司 | Macrocyclic compound |
EP3207038B1 (en) | 2014-10-16 | 2018-08-22 | Bayer Pharma Aktiengesellschaft | Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group |
CN107207475A (en) | 2014-10-16 | 2017-09-26 | 拜耳医药股份有限公司 | Fluorination benzofuranyl pyrimidine derivatives containing sulfone group |
DK3539961T3 (en) | 2015-06-29 | 2022-01-03 | Astrazeneca Ab | POLYCYCLIC AMID DERIVATIVES AS CDK9 INHIBITORS |
ES2900199T3 (en) | 2017-03-28 | 2022-03-16 | Bayer Ag | Novel PTEFB-inhibiting macrocyclic compounds |
CA3057891A1 (en) | 2017-03-28 | 2018-10-04 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
CN111566100B (en) * | 2018-02-12 | 2023-10-27 | 恩瑞生物医药科技(上海)有限公司 | Pyrimidine compound, preparation method and medical application thereof |
AU2019221019A1 (en) | 2018-02-13 | 2020-07-23 | Bayer Aktiengesellschaft | Use of 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large B-cell lymphoma |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7419984B2 (en) * | 2002-10-17 | 2008-09-02 | Cell Therapeutics, Inc. | Pyrimidines and uses thereof |
EP1678147B1 (en) * | 2003-09-15 | 2012-08-08 | Lead Discovery Center GmbH | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases |
EP1901747A2 (en) * | 2005-05-25 | 2008-03-26 | Ingenium Pharmaceuticals AG | Pyrimidine-based cdk inhibitors for treating pain |
-
2008
- 2008-04-24 WO PCT/EP2008/055015 patent/WO2008132138A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2008132138A1 (en) | 2008-11-06 |
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