CO2017011851A2 - Compuestos novedosos - Google Patents

Compuestos novedosos

Info

Publication number
CO2017011851A2
CO2017011851A2 CONC2017/0011851A CO2017011851A CO2017011851A2 CO 2017011851 A2 CO2017011851 A2 CO 2017011851A2 CO 2017011851 A CO2017011851 A CO 2017011851A CO 2017011851 A2 CO2017011851 A2 CO 2017011851A2
Authority
CO
Colombia
Prior art keywords
compounds
novel compounds
rip2 kinase
diseases
compositions
Prior art date
Application number
CONC2017/0011851A
Other languages
English (en)
Inventor
Afjal Hussain Miah
Mark David Rackham
Linda N Casillas
John David Harling
Ian Edward David Smith
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of CO2017011851A2 publication Critical patent/CO2017011851A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La presente invención se refiere a compuestos, composiciones, combinaciones y medicamentos que contienen dichos compuestos y a procedimientos para su preparación. La invención también se refiere al uso de dichos compuestos, combinaciones, composiciones y medicamentos, por ejemplo como inhibidores de la actividad de cinasa RIP2, incluyendo la degradación de cinasa RIP2, el tratamiento de enfermedades y estados mediados por la cinasa RIP2, en particular para el tratamiento de enfermedades o estados inflamatorios.
CONC2017/0011851A 2015-04-22 2017-11-21 Compuestos novedosos CO2017011851A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1506872.9A GB201506872D0 (en) 2015-04-22 2015-04-22 Novel compounds
PCT/US2016/028332 WO2016172134A2 (en) 2015-04-22 2016-04-20 Novel compounds

Publications (1)

Publication Number Publication Date
CO2017011851A2 true CO2017011851A2 (es) 2018-02-09

Family

ID=53299021

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0011851A CO2017011851A2 (es) 2015-04-22 2017-11-21 Compuestos novedosos

Country Status (21)

Country Link
US (2) US10435391B2 (es)
EP (1) EP3286169B1 (es)
JP (1) JP2018513867A (es)
KR (1) KR20170139096A (es)
CN (1) CN107709305B (es)
AU (1) AU2016252404B2 (es)
BR (1) BR112017022604A2 (es)
CA (1) CA2983414A1 (es)
CL (1) CL2017002650A1 (es)
CO (1) CO2017011851A2 (es)
CR (1) CR20170478A (es)
EA (1) EA033343B1 (es)
ES (1) ES2841548T3 (es)
GB (1) GB201506872D0 (es)
HK (1) HK1243410A1 (es)
IL (1) IL255067A0 (es)
MX (1) MX2017013556A (es)
PE (1) PE20180044A1 (es)
PH (1) PH12017501921A1 (es)
SG (1) SG11201708311UA (es)
WO (1) WO2016172134A2 (es)

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Also Published As

Publication number Publication date
CL2017002650A1 (es) 2018-03-16
AU2016252404B2 (en) 2018-07-26
ES2841548T3 (es) 2021-07-08
US20190382381A1 (en) 2019-12-19
EP3286169A4 (en) 2018-11-21
EA033343B1 (ru) 2019-09-30
GB201506872D0 (en) 2015-06-03
CN107709305A (zh) 2018-02-16
US20180134688A1 (en) 2018-05-17
HK1243410A1 (zh) 2018-07-13
CN107709305B (zh) 2020-09-29
PE20180044A1 (es) 2018-01-15
CR20170478A (es) 2018-01-22
US10435391B2 (en) 2019-10-08
MX2017013556A (es) 2018-08-01
AU2016252404A1 (en) 2017-12-07
WO2016172134A2 (en) 2016-10-27
JP2018513867A (ja) 2018-05-31
BR112017022604A2 (pt) 2018-07-17
PH12017501921A1 (en) 2018-03-19
CA2983414A1 (en) 2016-10-27
EP3286169A2 (en) 2018-02-28
IL255067A0 (en) 2017-12-31
KR20170139096A (ko) 2017-12-18
EP3286169B1 (en) 2020-10-07
WO2016172134A3 (en) 2016-12-01
SG11201708311UA (en) 2017-11-29
EA201792047A1 (ru) 2018-04-30

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