BR112017000830A2 - novas 2,5-piridinas substituídas - Google Patents

novas 2,5-piridinas substituídas

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Publication number
BR112017000830A2
BR112017000830A2 BR112017000830A BR112017000830A BR112017000830A2 BR 112017000830 A2 BR112017000830 A2 BR 112017000830A2 BR 112017000830 A BR112017000830 A BR 112017000830A BR 112017000830 A BR112017000830 A BR 112017000830A BR 112017000830 A2 BR112017000830 A2 BR 112017000830A2
Authority
BR
Brazil
Prior art keywords
new substituted
substituted pyridines
medicaments
pyridines
new
Prior art date
Application number
BR112017000830A
Other languages
English (en)
Inventor
Nardi Antonio
Hesslinger Christian
Jakob Florian
Konetzki Ingo
Craan Tobias
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BR112017000830A2 publication Critical patent/BR112017000830A2/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

novas 2,5-piridinas substituídas. a invenção está relacionada a novos compostos de pirimidina condensados substituídos de fórmula geral (i) na qual os agrupamentos químicos, substituintes e índices são como definido na descrição, e a seu uso como medicamentos, em particular como medicamentos para o tratamento de condições e doenças que podem ser tratadas pela inibição da enzima pde4.
BR112017000830A 2014-07-16 2015-07-16 novas 2,5-piridinas substituídas BR112017000830A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14002450 2014-07-16
PCT/EP2015/001473 WO2016008590A1 (en) 2014-07-16 2015-07-16 Novel 2,5-substituted pyrimidines as pde4 inhibitors

Publications (1)

Publication Number Publication Date
BR112017000830A2 true BR112017000830A2 (pt) 2017-12-05

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Application Number Title Priority Date Filing Date
BR112017000830A BR112017000830A2 (pt) 2014-07-16 2015-07-16 novas 2,5-piridinas substituídas

Country Status (19)

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US (2) US9546158B2 (pt)
EP (2) EP3415510A1 (pt)
JP (1) JP6723217B2 (pt)
KR (1) KR20170032421A (pt)
CN (1) CN106660996B (pt)
AR (1) AR101198A1 (pt)
AU (1) AU2015291475B2 (pt)
BR (1) BR112017000830A2 (pt)
CA (1) CA2955053A1 (pt)
CL (1) CL2017000106A1 (pt)
CO (1) CO2017001506A2 (pt)
EA (1) EA201790206A1 (pt)
EC (1) ECSP17010481A (pt)
IL (1) IL250026A0 (pt)
MX (1) MX366839B (pt)
PE (1) PE20170251A1 (pt)
TW (1) TW201613896A (pt)
WO (1) WO2016008590A1 (pt)
ZA (1) ZA201701131B (pt)

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AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
AR101196A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
WO2018065849A1 (en) 2016-10-03 2018-04-12 Koninklijke Philips N.V. Radiopaque arrangement of electronic components in intra-cardiac echocardiography (ice) catheter
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WO2018234354A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED 3-INDOLE AND 3-INDAZOLE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS
WO2018234353A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE
ES2960883T3 (es) * 2018-10-25 2024-03-07 Merck Patent Gmbh Derivados de 5-azaindazol como antagonistas de los receptores de adenosina
CN110156785B (zh) * 2019-04-15 2020-08-28 浙江大学 吲唑类化合物及其制备方法和应用
EP4255904A2 (en) * 2020-12-03 2023-10-11 Domain Therapeutics Novel par-2 inhibitors
CN115108992B (zh) * 2022-06-29 2024-05-31 浙江手心制药有限公司 6-氯-2-甲基-2h-吲唑-5-胺的制备方法

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US10391099B2 (en) 2019-08-27
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US9546158B2 (en) 2017-01-17
US20160016938A1 (en) 2016-01-21
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