CL2017000106A1 - Novedosas pirimidinas 2,5-sustituidas como inhibidores pde4 . - Google Patents
Novedosas pirimidinas 2,5-sustituidas como inhibidores pde4 .Info
- Publication number
- CL2017000106A1 CL2017000106A1 CL2017000106A CL2017000106A CL2017000106A1 CL 2017000106 A1 CL2017000106 A1 CL 2017000106A1 CL 2017000106 A CL2017000106 A CL 2017000106A CL 2017000106 A CL2017000106 A CL 2017000106A CL 2017000106 A1 CL2017000106 A1 CL 2017000106A1
- Authority
- CL
- Chile
- Prior art keywords
- innovative
- pde4 inhibitors
- substituted pyrimidines
- medications
- substitutes
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/33—Heterocyclic compounds
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
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- Hematology (AREA)
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- Immunology (AREA)
- Obesity (AREA)
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- Pain & Pain Management (AREA)
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- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
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Abstract
<p>COMPUESTOS CONDENSADOS SUSTITUIDOS DE PIRIMIDINA DE FÓRMULA GENERAL (I):</p> <p>* incluir figura de estructura de hoja resumen (pag 159)</p> <p>EN LOS CUALES LOS GRUPOS QUÍMICOS, SUSTITUYENTES E ÍNDICES SON TAL COMO SE LOS DEFINE EN LA DESCRIPCIÓN, Y SU USO COMO MEDICAMENTOS, EN PARTICULAR COMO MEDICAMENTOS PARA EL TRATAMIENTO DE CONDICIONES Y ENFERMEDADES QUE SE PUEDEN TRATAR POR INHIBICIÓN DE LA ENZIMA PDE4.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14002450 | 2014-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017000106A1 true CL2017000106A1 (es) | 2017-08-04 |
Family
ID=51210959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017000106A CL2017000106A1 (es) | 2014-07-16 | 2017-01-13 | Novedosas pirimidinas 2,5-sustituidas como inhibidores pde4 . |
Country Status (19)
Country | Link |
---|---|
US (2) | US9546158B2 (es) |
EP (2) | EP3415510A1 (es) |
JP (1) | JP6723217B2 (es) |
KR (1) | KR20170032421A (es) |
CN (1) | CN106660996B (es) |
AR (1) | AR101198A1 (es) |
AU (1) | AU2015291475B2 (es) |
BR (1) | BR112017000830A2 (es) |
CA (1) | CA2955053A1 (es) |
CL (1) | CL2017000106A1 (es) |
CO (1) | CO2017001506A2 (es) |
EA (1) | EA201790206A1 (es) |
EC (1) | ECSP17010481A (es) |
IL (1) | IL250026A0 (es) |
MX (1) | MX366839B (es) |
PE (1) | PE20170251A1 (es) |
TW (1) | TW201613896A (es) |
WO (1) | WO2016008590A1 (es) |
ZA (1) | ZA201701131B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR101198A1 (es) | 2014-07-16 | 2016-11-30 | Gruenenthal Gmbh | Pirimidinas 2,5-sustituidas como inhibidores de pde4b |
AR101196A1 (es) * | 2014-07-16 | 2016-11-30 | Gruenenthal Gmbh | Compuestos de pirimidina sustituidos |
US11963823B2 (en) | 2016-10-03 | 2024-04-23 | Koninklijke Philips N.V. | Radiopaque arrangement of electronic components in intra-cardiac echocardiography (ICE) catheter |
CN108570052A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用 |
WO2018234354A1 (en) | 2017-06-20 | 2018-12-27 | Grünenthal GmbH | NOVEL SUBSTITUTED 3-INDOLE AND 3-INDAZOLE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS |
WO2018234353A1 (en) | 2017-06-20 | 2018-12-27 | Grünenthal GmbH | NOVEL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE |
MX2021003901A (es) * | 2018-10-25 | 2021-06-04 | Merck Patent Gmbh | Derivados de 5-azaindazol como antagonistas del receptor de adenosina. |
CN110156785B (zh) * | 2019-04-15 | 2020-08-28 | 浙江大学 | 吲唑类化合物及其制备方法和应用 |
WO2022117882A2 (en) * | 2020-12-03 | 2022-06-09 | Domain Therapeutics | Novel par-2 inhibitors |
CN115108992B (zh) * | 2022-06-29 | 2024-05-31 | 浙江手心制药有限公司 | 6-氯-2-甲基-2h-吲唑-5-胺的制备方法 |
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ES2176252T3 (es) | 1993-07-02 | 2002-12-01 | Altana Pharma Ag | Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. |
JP2000198734A (ja) | 1998-12-30 | 2000-07-18 | Pfizer Inc | 胃運動性減弱および関連疾患の治療のための運動性増強薬 |
PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
JP2001233875A (ja) * | 1999-10-12 | 2001-08-28 | Takeda Chem Ind Ltd | ピリミジン−5−カルボキサミド化合物、その製造法およびその用途 |
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DK1773816T3 (en) | 2004-06-24 | 2015-01-26 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
US20060293343A1 (en) | 2005-05-18 | 2006-12-28 | Asahi Kasei Pharma Corporation | Pyrimidine derivatives |
RU2008117151A (ru) | 2005-09-30 | 2009-11-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Деазапурины, пригодные в качестве ингибиторов янус-киназ |
US7863446B2 (en) | 2006-01-19 | 2011-01-04 | Orchid Research Laboratories Limited | Heterocycles |
WO2007083182A2 (en) * | 2006-01-19 | 2007-07-26 | Orchid Research Laboratories Limited | Novel heterocycles |
EP1958947A1 (en) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type 4 |
TW201512189A (zh) | 2013-04-16 | 2015-04-01 | Gruenenthal Chemie | 新型被取代之嘧啶縮合化合物 |
AR101197A1 (es) * | 2014-07-16 | 2016-11-30 | Gruenenthal Gmbh | Pirimidinas 2,5-sustituidas |
AR101198A1 (es) | 2014-07-16 | 2016-11-30 | Gruenenthal Gmbh | Pirimidinas 2,5-sustituidas como inhibidores de pde4b |
AR101196A1 (es) * | 2014-07-16 | 2016-11-30 | Gruenenthal Gmbh | Compuestos de pirimidina sustituidos |
-
2015
- 2015-07-14 AR ARP150102233A patent/AR101198A1/es unknown
- 2015-07-15 US US14/800,252 patent/US9546158B2/en active Active
- 2015-07-16 MX MX2017000521A patent/MX366839B/es active IP Right Grant
- 2015-07-16 WO PCT/EP2015/001473 patent/WO2016008590A1/en active Application Filing
- 2015-07-16 EA EA201790206A patent/EA201790206A1/ru unknown
- 2015-07-16 EP EP18182049.9A patent/EP3415510A1/en not_active Withdrawn
- 2015-07-16 CN CN201580038259.8A patent/CN106660996B/zh not_active Expired - Fee Related
- 2015-07-16 PE PE2017000066A patent/PE20170251A1/es not_active Application Discontinuation
- 2015-07-16 JP JP2017502119A patent/JP6723217B2/ja not_active Expired - Fee Related
- 2015-07-16 EP EP15739175.6A patent/EP3169679A1/en not_active Withdrawn
- 2015-07-16 CA CA2955053A patent/CA2955053A1/en not_active Abandoned
- 2015-07-16 TW TW104123028A patent/TW201613896A/zh unknown
- 2015-07-16 KR KR1020177004412A patent/KR20170032421A/ko unknown
- 2015-07-16 AU AU2015291475A patent/AU2015291475B2/en not_active Ceased
- 2015-07-16 BR BR112017000830A patent/BR112017000830A2/pt not_active Application Discontinuation
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2016
- 2016-11-17 US US15/354,424 patent/US10391099B2/en not_active Expired - Fee Related
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2017
- 2017-01-10 IL IL250026A patent/IL250026A0/en unknown
- 2017-01-13 CL CL2017000106A patent/CL2017000106A1/es unknown
- 2017-02-15 ZA ZA2017/01131A patent/ZA201701131B/en unknown
- 2017-02-15 CO CONC2017/0001506A patent/CO2017001506A2/es unknown
- 2017-02-16 EC ECIEPI201710481A patent/ECSP17010481A/es unknown
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CA2955053A1 (en) | 2016-01-21 |
AU2015291475B2 (en) | 2019-02-07 |
IL250026A0 (en) | 2017-03-30 |
TW201613896A (en) | 2016-04-16 |
AU2015291475A1 (en) | 2017-03-09 |
EP3169679A1 (en) | 2017-05-24 |
AR101198A1 (es) | 2016-11-30 |
WO2016008590A1 (en) | 2016-01-21 |
EA201790206A1 (ru) | 2017-07-31 |
CO2017001506A2 (es) | 2017-05-10 |
CN106660996B (zh) | 2020-10-16 |
PE20170251A1 (es) | 2017-04-21 |
EP3415510A1 (en) | 2018-12-19 |
US20170065603A1 (en) | 2017-03-09 |
US20160016938A1 (en) | 2016-01-21 |
MX366839B (es) | 2019-07-26 |
ZA201701131B (en) | 2019-07-31 |
BR112017000830A2 (pt) | 2017-12-05 |
JP2017520598A (ja) | 2017-07-27 |
US9546158B2 (en) | 2017-01-17 |
JP6723217B2 (ja) | 2020-07-15 |
CN106660996A (zh) | 2017-05-10 |
ECSP17010481A (es) | 2017-03-31 |
MX2017000521A (es) | 2017-05-01 |
KR20170032421A (ko) | 2017-03-22 |
US10391099B2 (en) | 2019-08-27 |
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