BR112018076534A2 - compostos heterocíclicos como imunomoduladores - Google Patents

compostos heterocíclicos como imunomoduladores

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Publication number
BR112018076534A2
BR112018076534A2 BR112018076534-1A BR112018076534A BR112018076534A2 BR 112018076534 A2 BR112018076534 A2 BR 112018076534A2 BR 112018076534 A BR112018076534 A BR 112018076534A BR 112018076534 A2 BR112018076534 A2 BR 112018076534A2
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BR
Brazil
Prior art keywords
immunomodulators
compounds
heterocyclic compounds
infections
disorders
Prior art date
Application number
BR112018076534-1A
Other languages
English (en)
Inventor
Xiao Kaijiong
Zhang Fenglei
Wu Liangxing
Yao Wenqing
Original Assignee
Incyte Corporation
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Filing date
Publication date
Application filed by Incyte Corporation filed Critical Incyte Corporation
Publication of BR112018076534A2 publication Critical patent/BR112018076534A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

a presente invenção refere-se a compostos de fórmula (i), métodos de utilização dos compostos como imunomoduladores e composições farmacêuticas compreendendo tais compostos. os compostos são úteis no tratamento, prevenção ou melhoria de doenças ou distúrbios, tais como câncer ou infecções.
BR112018076534-1A 2016-06-20 2017-06-19 compostos heterocíclicos como imunomoduladores BR112018076534A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662352485P 2016-06-20 2016-06-20
US62/352,485 2016-06-20
US201662396353P 2016-09-19 2016-09-19
US62/396,353 2016-09-19
PCT/US2017/038120 WO2017222976A1 (en) 2016-06-20 2017-06-19 Heterocyclic compounds as immunomodulators

Publications (1)

Publication Number Publication Date
BR112018076534A2 true BR112018076534A2 (pt) 2019-04-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018076534-1A BR112018076534A2 (pt) 2016-06-20 2017-06-19 compostos heterocíclicos como imunomoduladores

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US (4) US20170362253A1 (pt)
EP (2) EP3472167B1 (pt)
JP (2) JP7000357B2 (pt)
KR (1) KR20190035694A (pt)
CN (1) CN109890819B (pt)
AU (2) AU2017281285C1 (pt)
BR (1) BR112018076534A2 (pt)
CA (1) CA3028685A1 (pt)
CL (1) CL2018003701A1 (pt)
CO (1) CO2019000386A2 (pt)
DK (1) DK3472167T3 (pt)
EC (1) ECSP19003773A (pt)
ES (1) ES2927984T3 (pt)
HR (1) HRP20221030T1 (pt)
HU (1) HUE060256T2 (pt)
IL (1) IL263825B (pt)
LT (1) LT3472167T (pt)
MD (1) MD3472167T2 (pt)
MX (2) MX2018016273A (pt)
MY (1) MY197280A (pt)
PE (1) PE20190731A1 (pt)
PH (1) PH12018502710A1 (pt)
PL (1) PL3472167T3 (pt)
PT (1) PT3472167T (pt)
RS (1) RS63673B1 (pt)
SG (2) SG10202012828TA (pt)
SI (1) SI3472167T1 (pt)
TW (1) TWI771305B (pt)
UA (1) UA125391C2 (pt)
WO (1) WO2017222976A1 (pt)

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