AR044402A1 - Compuestos heterociclicos y su uso como inmunodepresores. composiciones farmaceuticas que los contienen. - Google Patents

Compuestos heterociclicos y su uso como inmunodepresores. composiciones farmaceuticas que los contienen.

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Publication number
AR044402A1
AR044402A1 ARP040101735A ARP040101735A AR044402A1 AR 044402 A1 AR044402 A1 AR 044402A1 AR P040101735 A ARP040101735 A AR P040101735A AR P040101735 A ARP040101735 A AR P040101735A AR 044402 A1 AR044402 A1 AR 044402A1
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AR
Argentina
Prior art keywords
alkyl
halogen
substituted
alkoxy
hydrogen
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ARP040101735A
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English (en)
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Irm Llc
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Publication of AR044402A1 publication Critical patent/AR044402A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P35/00—Antineoplastic agents
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)

Abstract

La presente se refiere a un inmunosupresor, sus usos y composiciones farmacéuticas que lo contienen. La presente proporciona una clase de compuestos para el tratamiento o prevención de enfermedades o trastornos mediados por interacciones de linfocito, particularmente enfermedades asociadas con la transducción de señal mediada por el receptor de EDG. Reivindicación 1: Un compuesto de la fórmula (1), en donde: n es 1 ó 2; A se selecciona de -C(O)OR9, -OP(O)(OR9)2, -P(O)(OR9)2, -S(O)2OR9, -P(O)(R9)OR9, y 1H-tetrazol-5-ilo; y R9 se selecciona de hidrógeno y alquilo C1-6; X es un enlace o se selecciona de alquileno C1-4, -X1OX2-, -X1NR10X2-, -X1C(O)NR10X2-, -X1NR10C(O)X2-, -X1S(O)X2-, -X1S(O)2X2-, -X1SX2- y heteroarileno C2-9; en donde X1 y X2 independientemente se seleccionan de un enlace y alquileno C1-3; R10 se selecciona de hidrógeno y alquilo C1-6; y cualquier heteroarileno de X está opcionalmente sustituido por un miembro del grupo seleccionado de halógeno y alquilo C1-6; Y es un sistema de anillo heterociclico de 5,6 ó 6,6, fusionado que consiste de por lo menos un anillo aromático, en donde dicho sistema de anillo bicíclico fusionado de Y puede estar opcionalmente sustituido con 1 a 3 radicales seleccionados de halógeno, hidroxi, ciano, nitro, alquilo C1-6, alcoxi C1-6, alquilo C1-6 sustituido con halógeno y alcoxi C1-6 sustituido con halógeno; R1 se selecciona de arilo C6-10 y heteroarilo C2-9; en donde cualquier arilo o heteroarilo de R1 está opcionalmente sustituido por un radical seleccionado de arilo(C6-10)-alquilo(C0-4), heteroarilo(C2-9)-alquilo(C0-4), cicloalquilo(C3-8)-alquilo(C0-4), heterocicloalquilo(C3-8)-alquilo(C0-4), o alquilo C1-6; en donde cualquier grupo arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R1 puede estar opcionalmente sustituido por 1 a 3 radicales seleccionados de halógeno, alquilo C1-6, alcoxi C1-6, alquilo C1-6 sustituido con halógeno y alcoxi C1-6 sustituido con halógeno; y cualquier grupo alquilo de R1 opcionalmente puede tener un metileno reemplazado por un átomo o grupo seleccionado de -S-, S(O)-, S(O)2-, -NR10- y -O-; en donde R10 se selecciona de hidrógeno o alquilo C1-4; R2, R3, R5, R6, R7 y R8 se seleccionan independientemente de hidrógeno, alquilo C1-6, halógeno, hidroxi, alcoxi C1-6, alquilo C1-6 sustituido con halógeno y alcoxi C1-6 sustituido con halógeno; R4 se selecciona de hidrógeno y alquilo C1-6; o R7 y cualquiera de R2, R4 o R5 junto con los átomos a los cuales R2, R4, R5 y R7 están unidos, forman un anillo de 4 a 7 miembros; en donde dicho anillo de 4 a 7 miembros está saturado o parcialmente insaturado; y las sales, hidratos, solvatos, isómeros y profármacos farmacéuticamente.
ARP040101735A 2003-05-19 2004-05-19 Compuestos heterociclicos y su uso como inmunodepresores. composiciones farmaceuticas que los contienen. AR044402A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47193103P 2003-05-19 2003-05-19
US56218304P 2004-04-14 2004-04-14

Publications (1)

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AR044402A1 true AR044402A1 (es) 2005-09-14

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Country Link
US (2) US7417065B2 (es)
EP (2) EP2644195A1 (es)
JP (1) JP4944613B2 (es)
AR (1) AR044402A1 (es)
AU (2) AU2004251146A1 (es)
BR (1) BRPI0410439A (es)
CA (1) CA2524048C (es)
CL (1) CL2004001120A1 (es)
ES (1) ES2467160T3 (es)
HK (1) HK1090639A1 (es)
MX (1) MXPA05012461A (es)
PE (1) PE20050158A1 (es)
TW (1) TW200505442A (es)
WO (1) WO2005000833A1 (es)

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GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
TW200538433A (en) * 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
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MX2007006373A (es) 2004-11-29 2007-06-20 Novartis Ag Regimen de dosificacion de un agonista del receptor s1p.
CA2595960A1 (en) * 2005-02-08 2006-08-17 Novartis Ag Antilymphocyte antibody induction by combination of an s1p receptor agonist/modulator and of immunosuppressive drugs
GB0504544D0 (en) 2005-03-04 2005-04-13 Novartis Ag Organic compounds
WO2006104668A2 (en) * 2005-03-11 2006-10-05 Temple University - Of The Commonwealth System Of Higher Education Composition and methods for the treatment of proliferative diseases
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