AR044403A1 - Derivados de oximas y su uso como inmunodepresores. composiciones farmaceuticas que los contienen. - Google Patents
Derivados de oximas y su uso como inmunodepresores. composiciones farmaceuticas que los contienen.Info
- Publication number
- AR044403A1 AR044403A1 ARP040101736A ARP040101736A AR044403A1 AR 044403 A1 AR044403 A1 AR 044403A1 AR P040101736 A ARP040101736 A AR P040101736A AR P040101736 A ARP040101736 A AR P040101736A AR 044403 A1 AR044403 A1 AR 044403A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- substituted
- heteroaryl
- aryl
- Prior art date
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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Abstract
La presente se refiere a un inmunosupresor, sus usos y composiciones farmacéuticas que lo contienen. La presente proporciona una clase de compuestos para el tratamiento o prevención de enfermedades o trastornos mediados por interacciones de linfocito, particularmente enfermedades asociadas con la transducción de señal mediada por el receptor de EDG. Reivindicación 1: Un compuesto seleccionado de la fórmula (1) y (2), en donde: A se selecciona de -C(O)OR5, -OP(O)(OR5)2, -P(O)(OR5)2, - S(O)2OR5, -P(O)(R5)OR5, y 1H-tetrazol-5-ilo; en donde cada R5 se selecciona independientemente de hidrógeno y alquilo C1-6; W se selecciona de un enlace, alquileno C1-3, alquenileno C2-3; Y se selecciona de arilo C6-10 y heteroarilo C2-9; en donde cualquier arilo o heteroarilo de Y puede ser opcionalmente sustituido con 1 a 3 radicales seleccionados de halógeno, hidroxi, nitro, alquilo C1-6, alcoxi C1-6, alquilo C1-6 sustituido con halógeno, y alcoxi C1-6 sustituido con halógeno; Z se selecciona de un resto del grupo de fórmulas (3), en donde los asteriscos de la izquierda y derecha de Z indican el punto de unión entre -C(R3)(R4)- y A de la fórmula (1) o (2), respectivamente; R6 se selecciona de hidrógeno y alquilo C1-6; y J1 y J2 son independientemente metileno o un átomo heterogéneo seleccionado de S, O y NR5; en donde R5 se selecciona de hidrógeno y alquilo C1-6; y cualquier alquileno de Z además puede ser sustituido por 1 a 3 radicales seleccionados de halógeno, hidroxi, alquilo C1-6; o R6 puede unirse a un átomo de carbono de Y para formar un anillo de 5-7 miembros; R1 se selecciona de arilo C6-10 y heteroarilo C2-9; en donde cualquier arilo o heteroarilo de R1 está opcionalmente sustituido por un radical seleccionado de arilo(C6-10)-alquilo(C0-4), heteroarilo(C2-9)-alquilo(C0-4), cicloalquilo(C3-8)-alquilo(C0-4), heterocicloalquilo(C3-8)-alquilo(C0-4), o alquilo C1-6; en donde cualquier grupo arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R1 puede estar opcionalmente sustituido por 1 a 5 radicales seleccionados de halógeno, alquilo C1-6, alcoxi C1-6, alquilo C1-6 sustituido con halógeno y alcoxi C1-6 sustituido con halógeno; y cualquier grupo alquilo de R1 opcionalmente puede tener un metileno reemplazado por un átomo o grupo seleccionado de -S-, -S(O)-, S(O)2-, -NR5- y -O-; en donde R5 se selecciona de hidrógeno o alquilo C1-6; R2 se selecciona de hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, y alquilo C1-6 sustituido con halógeno; R3 y R4 se seleccionan independientemente de hidrógeno, alquilo C1-6, halógeno, hidroxi, alcoxi(C1-6)-alquilo(C1-6) sustituido con halógeno y alcoxi C1-6 sustituido con halógeno; y sales, hidratos, solvatos, isómeros y profármacos farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US47193103P | 2003-05-19 | 2003-05-19 | |
US56196804P | 2004-04-14 | 2004-04-14 |
Publications (1)
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AR044403A1 true AR044403A1 (es) | 2005-09-14 |
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ID=33479305
Family Applications (1)
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ARP040101736A AR044403A1 (es) | 2003-05-19 | 2004-05-19 | Derivados de oximas y su uso como inmunodepresores. composiciones farmaceuticas que los contienen. |
Country Status (33)
Country | Link |
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US (2) | US20050014728A1 (es) |
EP (4) | EP2514743B1 (es) |
JP (2) | JP4700616B2 (es) |
KR (1) | KR101118779B1 (es) |
CN (1) | CN102875413A (es) |
AR (1) | AR044403A1 (es) |
AU (2) | AU2004240637A1 (es) |
BR (1) | BRPI0410741B8 (es) |
CA (1) | CA2524047C (es) |
CL (1) | CL2004001119A1 (es) |
CY (1) | CY1118299T1 (es) |
DK (1) | DK1633336T3 (es) |
EC (1) | ECSP056148A (es) |
ES (1) | ES2593463T3 (es) |
HK (1) | HK1087929A1 (es) |
HR (1) | HRP20161156T1 (es) |
HU (1) | HUE030772T2 (es) |
IL (1) | IL171683A (es) |
IS (1) | IS3007B (es) |
LT (1) | LT1633336T (es) |
MA (1) | MA27807A1 (es) |
MX (1) | MXPA05012462A (es) |
MY (1) | MY150088A (es) |
NO (1) | NO334457B1 (es) |
NZ (1) | NZ543241A (es) |
PE (1) | PE20050626A1 (es) |
PL (1) | PL1633336T3 (es) |
PT (1) | PT1633336T (es) |
RU (1) | RU2009132108A (es) |
SI (1) | SI1633336T1 (es) |
TN (1) | TNSN05294A1 (es) |
TW (1) | TWI355931B (es) |
WO (1) | WO2004103306A2 (es) |
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