BR0213465A - Compostos de 4-imidazolin-2-ona - Google Patents

Compostos de 4-imidazolin-2-ona

Info

Publication number
BR0213465A
BR0213465A BR0213465-9A BR0213465A BR0213465A BR 0213465 A BR0213465 A BR 0213465A BR 0213465 A BR0213465 A BR 0213465A BR 0213465 A BR0213465 A BR 0213465A
Authority
BR
Brazil
Prior art keywords
alkyl
substitutable
atom
hydrogen atom
imidazolin
Prior art date
Application number
BR0213465-9A
Other languages
English (en)
Inventor
Akira Kubo
Ritsuo Imashiro
Hiroaki Sakurai
Hidetaka Miyoshi
Akihito Ogasawara
Hajime Hiramatsu
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of BR0213465A publication Critical patent/BR0213465A/pt

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Neurology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
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  • Endocrinology (AREA)
  • Hematology (AREA)
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  • Communicable Diseases (AREA)

Abstract

"COMPOSTOS DE 4-IMIDAZOLIN-2-ONA". A presente invenção refere-se a um composto da fórmula [I]: em que G^ 1^ é uma alquila que pode ser substituída por um átomo de halogênio ou um alcóxi, ou um grupo da fórmula: em que o anel B é um anel benzeno que pode ser substituído etc. Q^ 1^ e Q^ 2^ podem ser iguais ou diferentes, e cada um é um átomo de hidrogênio, um átomo de halogênio ou uma alquila, n é 0, 1, 2, 3 ou 4, R^ 1^ é um átomo de hidrogênio, uma alquila que pode ser substituída, uma cicloalquila que pode ser substituída, uma fenila que pode ser substituída etc., Z^ 1^, Z^ 2^, Z^ 3^ e Z^ 4^ podem ser iguais ou diferentes, e cada um é CH ou N, contanto que 3 ou mais de Z^ 1^, Z^ 2^, Z^ 3^ e Z^ 4^ não sejam N ao mesmo tempo, G^ 2^ é um átomo de hidrogênio, -NR^ 3^R^ 4^, -OR^ 5^, etc., em que R^ 3^ a R^ 8^ são independentemente um átomo de hidrogênio, uma alquila que pode ser substituída, uma alquenila, uma alquinila etc., ou um sal farmaceuticamente aceitável do mesmo.
BR0213465-9A 2001-10-22 2002-10-22 Compostos de 4-imidazolin-2-ona BR0213465A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001324029 2001-10-22
JP2002263680 2002-09-10
PCT/JP2002/010937 WO2003035638A1 (fr) 2001-10-22 2002-10-22 Composes de 4-imidazolin-2-one

Publications (1)

Publication Number Publication Date
BR0213465A true BR0213465A (pt) 2004-11-09

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ID=26624024

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BR0213465-9A BR0213465A (pt) 2001-10-22 2002-10-22 Compostos de 4-imidazolin-2-ona

Country Status (16)

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EP (1) EP1439174B1 (pt)
JP (1) JP4432492B2 (pt)
KR (1) KR100742058B1 (pt)
CN (1) CN100402521C (pt)
AT (1) ATE550332T1 (pt)
BR (1) BR0213465A (pt)
CA (1) CA2461100C (pt)
HU (1) HUP0401949A3 (pt)
IL (2) IL160874A0 (pt)
MX (1) MXPA04003729A (pt)
MY (1) MY147948A (pt)
NO (1) NO20042010L (pt)
PH (1) PH12009500610A1 (pt)
PL (1) PL210470B1 (pt)
TW (1) TWI329642B (pt)
WO (1) WO2003035638A1 (pt)

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JP2007145819A (ja) * 2005-10-28 2007-06-14 Tanabe Seiyaku Co Ltd 医薬組成物
CN101130539B (zh) * 2007-09-26 2012-05-30 浙江大学 吲哚取代咪唑啉-2-酮类衍生物及其制备方法和用途
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DE102009049679A1 (de) 2009-10-19 2011-04-21 Merck Patent Gmbh Pyrazolopyrimidinderivate
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WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods

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JP2005504004A (ja) * 2001-03-26 2005-02-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 四置換イミダゾール誘導体の製造方法およびそれの新規な結晶構造

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EP1439174B1 (en) 2012-03-21
CA2461100A1 (en) 2003-05-01
PH12009500610A1 (en) 2016-06-13
EP1439174A1 (en) 2004-07-21
IL160874A (en) 2012-05-31
NO20042010L (no) 2004-07-09
HUP0401949A3 (en) 2009-07-28
KR100742058B1 (ko) 2007-07-23
KR20040047942A (ko) 2004-06-05
ATE550332T1 (de) 2012-04-15
CN100402521C (zh) 2008-07-16
WO2003035638A1 (fr) 2003-05-01
CA2461100C (en) 2009-12-01
IL160874A0 (en) 2004-08-31
MXPA04003729A (es) 2004-07-23
EP1439174A4 (en) 2004-12-22
TWI329642B (en) 2010-09-01
PL210470B1 (pl) 2012-01-31
MY147948A (en) 2013-02-15
HUP0401949A2 (hu) 2005-01-28
PL369287A1 (en) 2005-04-18
JP4432492B2 (ja) 2010-03-17
CN1571781A (zh) 2005-01-26

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